The Oakland Athletics and the Baltimore Orioles were tied for the most runs in a game in 2000, with 23 runs.

Interpreted as:

highest scoring MLB regular-season game by a team 2000

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Athletics	23	9/30/2000	OAK	vs	TEX	W 23-2	48	24	5	0	4	23	10	0	10	0	0	58	41	9	0	0	0	0	.500	.586	.854	1.440
2	Orioles	23	9/28/2000	BAL	vs	TOR	W 23-1	47	23	2	0	3	20	5	1	5	0	0	54	34	5	0	1	0	1	.489	.537	.723	1.260
3	Yankees	22	6/19/2000	NYY	@	BOS	W 22-1	47	19	4	1	5	21	7	0	4	1	0	55	40	10	0	1	1	0	.404	.473	.851	1.324
4	Mariners	21	9/30/2000	SEA	@	ANA	W 21-9	46	22	4	1	5	20	11	0	9	2	1	59	43	10	1	1	0	0	.478	.569	.935	1.504
5	Athletics	21	6/18/2000	OAK	@	KCR	W 21-3	46	21	5	0	4	21	10	0	8	0	0	57	38	9	0	1	0	0	.457	.544	.826	1.370
6	White Sox	19	8/9/2000	CWS	vs	SEA	W 19-3	48	24	5	0	4	19	5	0	4	1	0	53	41	9	0	0	0	1	.500	.547	.854	1.401
7	Yankees	19	7/25/2000	NYY	@	BAL	W 19-1	43	20	1	0	5	19	7	0	5	0	1	52	36	6	1	1	0	0	.465	.529	.837	1.367
8	Rockies	19	6/18/2000	COL	vs	ARI	W 19-2	47	23	5	1	4	19	2	0	9	0	0	49	42	10	0	0	0	0	.489	.510	.894	1.404
9	Cardinals	19	5/20/2000	STL	@	PIT	W 19-4	46	19	2	1	3	16	6	2	7	1	0	55	32	6	0	1	0	1	.413	.491	.696	1.187
10	Mariners	19	4/16/2000	SEA	@	TOR	W 19-7	47	22	5	1	5	19	6	2	8	0	1	55	44	11	0	0	0	0	.468	.545	.936	1.482
11	Rockies	18	7/18/2000	COL	vs	OAK	W 18-3	44	21	4	0	2	17	5	0	3	0	0	51	31	6	0	2	0	1	.477	.510	.705	1.214
12	Tigers	18	6/20/2000	DET	@	TOR	W 18-6	41	18	3	1	8	18	9	0	3	0	0	50	47	12	0	0	0	4	.439	.540	1.146	1.686
13	Giants	18	6/4/2000	SFG	@	OAK	W 18-2	45	19	6	0	5	17	5	0	7	0	0	51	40	11	0	1	0	1	.422	.471	.889	1.359
14	Giants	18	5/24/2000	SFG	vs	MON	W 18-0	41	18	1	1	3	18	4	1	7	0	0	48	30	5	1	1	0	1	.439	.489	.732	1.221
15	White Sox	18	4/18/2000	CWS	vs	SEA	W 18-11	40	19	3	0	3	18	8	1	5	1	0	51	31	6	0	2	1	1	.475	.549	.775	1.324
16	Athletics	17	9/15/2000	OAK	@	TBD	W 17-3	46	20	4	0	3	17	8	0	7	0	0	54	33	7	0	0	0	2	.435	.519	.717	1.236
17	Diamondbacks	17	7/27/2000	ARI	@	STL	W 17-5	46	19	5	0	4	15	4	0	13	0	0	52	36	9	1	1	0	0	.413	.451	.783	1.234
18	Expos	17	7/22/2000	MON	@	FLA	W 17-7	44	19	3	0	2	16	7	1	12	1	0	53	28	5	0	1	0	1	.432	.509	.636	1.146
19	Expos	17	7/3/2000	MON	@	ATL	W 17-1	43	18	2	0	5	17	4	1	6	0	1	51	35	7	2	1	0	0	.419	.469	.814	1.283
20	Rockies	17	6/28/2000	COL	vs	SFG	W 17-13	42	17	5	1	4	16	10	0	6	3	0	52	36	10	0	0	1	0	.405	.519	.857	1.376
21	White Sox	17	6/18/2000	CWS	@	NYY	W 17-4	45	18	5	0	1	17	12	0	9	1	0	57	26	6	0	0	0	0	.400	.526	.578	1.104
22	White Sox	17	6/6/2000	CWS	@	CIN	W 17-12	45	19	7	0	1	16	7	1	7	0	0	54	29	8	0	1	0	1	.422	.500	.644	1.144
23	Rangers	17	5/5/2000	TEX	vs	OAK	W 17-16	44	21	3	0	1	17	5	1	5	0	1	51	27	4	1	0	0	1	.477	.540	.614	1.154
24	Mariners	17	4/15/2000	SEA	@	TOR	W 17-6	44	16	4	0	3	15	7	1	5	1	0	53	29	7	0	1	0	0	.364	.453	.659	1.112
25	Indians	17	4/9/2000	CLE	@	TBD	W 17-4	44	16	4	2	3	17	4	1	12	0	0	50	33	9	0	1	0	0	.364	.420	.750	1.170