Jose Quintana is 3-2 with an ERA of 3.36 and 55 strikeouts in 12 appearances against the Astros in his career.
| NAME | DATE | TM | OPP | DEC | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Quintana | 6/17/2013 | @ | 1 | 3.86 | 5 | 0 | 0 | 0 | 4.2 | 5 | 2 | 2 | 0 | 3 | 0 | 0 | 1 | 22 | 0 | |||
| 2 | | J. Quintana | 8/27/2013 | vs | 1 | 3.52 | 8 | 0 | 0 | 0 | 7.2 | 8 | 3 | 3 | 0 | 3 | 0 | 0 | 0 | 32 | 0 | |||
| 3 | | J. Quintana | 5/16/2014 | @ | W | 1 | 3.60 | 5 | 0 | 0 | 0 | 5.0 | 7 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 24 | 0 | ||
| 4 | | J. Quintana | 7/18/2014 | vs | 1 | 3.60 | 8 | 0 | 0 | 0 | 5.0 | 3 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 20 | 0 | |||
| 5 | | J. Quintana | 5/30/2015 | @ | L | 1 | 1.42 | 7 | 0 | 0 | 0 | 6.1 | 5 | 1 | 1 | 0 | 4 | 0 | 0 | 0 | 26 | 0 | ||
| 6 | | J. Quintana | 6/10/2015 | vs | W | 1 | 1.29 | 3 | 0 | 0 | 0 | 7.0 | 6 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 31 | 1 | ||
| 7 | | J. Quintana | 7/3/2016 | @ | W | 1 | 1.29 | 4 | 0 | 0 | 0 | 7.0 | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 25 | 0 | ||
| 8 | | J. Quintana | 4/5/2021 | vs | 1 | 10.80 | 5 | 0 | 0 | 0 | 3.1 | 5 | 4 | 4 | 0 | 3 | 0 | 0 | 0 | 19 | 1 | |||
| 9 | | J. Quintana | 8/13/2021 | vs | 0 | 0.00 | 2 | 0 | 0 | 0 | 2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | |||
| 10 | | J. Quintana | 8/15/2021 | vs | 0 | 0.00 | 0 | 0 | 0 | 0 | 0.2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | |||
| 11 | | J. Quintana | 6/28/2024 | vs | 1 | 4.50 | 7 | 0 | 0 | 0 | 4.0 | 6 | 2 | 2 | 1 | 3 | 0 | 0 | 0 | 21 | 0 | |||
| 12 | | J. Quintana | 4/15/2026 | @ | L | 1 | 7.36 | 1 | 0 | 0 | 0 | 3.2 | 3 | 3 | 3 | 1 | 4 | 0 | 0 | 0 | 18 | 0 | ||
| Total | 10 | 3.36 | 55 | 0 | 0 | 0 | 56.1 | 52 | 21 | 21 | 3 | 28 | 0 | 0 | 1 | 247 | 2 |
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