The New York Yankees have the highest run differential by a team, with a differential of 13,139 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,139	19,063	.570	10,808	8,167	649,712	92,643	172,487	28,639	5,494	17,325	86,082	68,598	4,929	94,856	11,651	2,801	736,119	264,089	51,458	9,595	3,285	2,832	10,681	.265	.339	.406	.745
2	Giants	7,476	21,773	.535	11,570	10,040	743,091	100,681	195,457	31,354	7,037	15,591	90,154	68,311	5,675	99,597	16,516	3,145	831,758	287,658	53,982	11,666	3,015	4,018	10,182	.263	.329	.387	.716
3	Dodgers	6,244	21,689	.532	11,463	10,087	739,020	97,928	193,093	31,062	7,006	14,136	88,148	68,910	5,150	100,365	17,343	3,550	828,991	280,575	52,204	12,774	3,061	3,735	9,944	.261	.327	.380	.707
4	Cubs	3,604	22,305	.513	11,357	10,787	763,319	102,713	199,914	33,759	7,360	15,253	88,299	68,579	5,285	105,070	15,795	3,070	853,118	294,152	56,372	13,026	2,909	3,521	9,963	.262	.326	.385	.711
5	Red Sox	3,585	19,352	.518	9,980	9,289	662,323	90,372	176,730	33,123	5,600	14,605	83,808	66,814	4,806	95,590	9,635	2,552	747,879	264,868	53,328	10,596	3,340	2,997	11,547	.267	.337	.400	.737
6	Guardians	2,246	19,360	.513	9,878	9,391	659,849	87,525	174,683	31,148	5,497	13,920	80,890	62,628	4,835	94,602	11,911	3,389	742,131	258,585	50,565	11,463	3,356	2,545	10,527	.265	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,967	20,656	.513	10,532	9,993	706,565	92,424	187,770	31,835	7,049	12,862	84,484	64,195	5,202	98,169	15,014	3,616	791,078	272,289	51,746	11,973	3,143	3,775	10,137	.266	.330	.385	.715
9	Braves	1,534	22,265	.504	11,138	10,973	762,312	99,515	197,988	32,111	6,301	15,056	86,562	67,502	5,067	100,147	14,098	3,067	850,445	287,869	53,468	12,684	2,880	3,655	10,383	.260	.323	.378	.701
10	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	769	21,890	.504	10,959	10,792	745,850	98,218	194,321	32,392	7,558	14,325	87,363	66,714	5,507	102,305	18,166	3,407	833,938	284,804	54,275	12,662	3,037	3,646	9,719	.261	.325	.382	.707
13	Astros	722	10,028	.502	5,034	4,989	340,308	42,761	86,746	15,908	2,172	8,426	40,244	32,359	2,900	62,939	7,149	3,135	382,310	132,276	26,506	4,030	2,713	3,144	7,410	.255	.323	.389	.711
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	375	7,600	.498	3,785	3,812	260,386	35,135	67,716	13,533	1,491	8,260	33,327	24,142	2,425	48,982	4,575	1,963	290,580	109,011	23,284	1,502	2,125	1,401	5,927	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	341	19,386	.503	9,709	9,584	661,096	89,037	174,667	29,593	6,295	14,582	81,990	65,555	4,448	96,736	11,292	2,937	745,218	260,596	50,470	11,009	3,110	2,447	10,717	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331