The Chicago White Stockings have the highest run differential by a team in a game, with a differential of 31 runs against the Cleveland Blues on July 24, 1882.
Interpreted as:
largest run differential in an MLB regular-season game| TEAM | DIFF | DATE | TM | OPP | RESULT | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | White Stockings | 31 | 7/24/1882 |  CWS | vs | CLE | W 35-4 | 35 | ||||||||||||||||||||||
| 2 | | Colts | 29 | 6/29/1897 | CHI | vs | LOU | W 36-7 | 36 | ||||||||||||||||||||||
| 3 |  | Giants | 28 | 6/15/1887 |  NYG | vs |  PHN | W 29-1 | 29 | ||||||||||||||||||||||
| 4 | Grays | 28 | 8/21/1883 | PRO | vs | PHN | W 28-0 | 28 | |||||||||||||||||||||||
| 5 |  | Rangers | 27 | 8/22/2007 |  TEX | @ |  BAL | W 30-3 | 57 | 30 | 29 | 2 | 0 | 6 | 30 | 8 | 0 | 11 | 0 | 0 | 65 | 49 | 8 | 0 | 0 | 0 | 0 | .509 | .569 | .860 | 1.429 |
| 6 |  | Brewers | 27 | 9/10/1891 |  MIL | vs |  WSH | W 30-3 | 30 | ||||||||||||||||||||||
| 7 |  | Red Sox | 25 | 6/8/1950 |  BSA | vs |  SLA | W 29-4 | 53 | 29 | 28 | 9 | 1 | 7 | 29 | 11 | 0 | 2 | 0 | 0 | 64 | 60 | 17 | 0 | 0 | 0 | .528 | .609 | 1.132 | 1.741 | |
| 8 |  | Phillies | 25 | 8/17/1894 | PHI | vs | LOU | W 29-4 | 29 | ||||||||||||||||||||||
| 9 |  | Beaneaters | 25 | 6/20/1883 |  BSN | vs | PHN | W 29-4 | 29 | ||||||||||||||||||||||
| 10 | Dark Blues | 25 | 5/13/1876 | HAR | vs |  NYM | W 28-3 | 28 | |||||||||||||||||||||||
| 11 |  | Angels | 24 | 6/24/2023 |  LAA | @ |  COL | W 25-1 | 52 | 25 | 28 | 5 | 0 | 5 | 25 | 6 | 1 | 3 | 0 | 0 | 59 | 48 | 10 | 0 | 0 | 0 | 3 | .538 | .593 | .923 | 1.516 |
| 12 |  | Indians | 24 | 7/7/1923 |  CLE | vs |  BSA | W 27-3 | 43 | 27 | 24 | 5 | 2 | 0 | 25 | 14 | 1 | 1 | 4 | 2 | 61 | 33 | 7 | 3 | .558 | .672 | .767 | 1.440 | |||
| 13 | | Quakers | 24 | 6/28/1887 | PHN | @ | IND | W 24-0 | 24 | ||||||||||||||||||||||
| 14 | | Giants | 24 | 6/11/1887 | NYG | vs |  WSH | W 26-2 | 26 | ||||||||||||||||||||||
| 15 |  | Grays | 24 | 6/24/1886 |  BKN | vs |  BAL | W 25-1 | 25 | ||||||||||||||||||||||
| 16 | | Gothams | 24 | 5/27/1885 | NYG | vs | BUF | W 24-0 | 24 | ||||||||||||||||||||||
| 17 | | White Stockings | 24 | 7/3/1883 | CWS | vs | BUF | W 31-7 | 31 | ||||||||||||||||||||||
| 18 |  | Blue Jays | 23 | 7/22/2022 |  TOR | @ | BOS | W 28-5 | 57 | 28 | 29 | 5 | 0 | 5 | 28 | 5 | 1 | 9 | 0 | 0 | 63 | 49 | 10 | 0 | 0 | 0 | 0 | .509 | .556 | .860 | 1.415 |
| 19 |  | White Sox | 23 | 4/23/1955 |  CWS | @ |  KCA | W 29-6 | 54 | 29 | 29 | 5 | 0 | 7 | 28 | 6 | 1 | 4 | 1 | 1 | 63 | 55 | 12 | 0 | 2 | 1 | 0 | .537 | .571 | 1.019 | 1.590 |
| 20 | | Indians | 23 | 8/12/1948 | CLE | @ | SLA | W 26-3 | 55 | 26 | 29 | 5 | 1 | 4 | 24 | 6 | 0 | 4 | 4 | 0 | 61 | 48 | 10 | 0 | 2 | .527 | .574 | .873 | 1.446 | ||
| 21 |  | Yankees | 23 | 5/24/1936 |  NYY | @ |  PHA | W 25-2 | 45 | 25 | 19 | 3 | 3 | 6 | 25 | 16 | 0 | 5 | 0 | 0 | 61 | 46 | 12 | 0 | .422 | .574 | 1.022 | 1.596 | |||
| 22 |  | Reds | 23 | 6/4/1911 |  CIN | vs |  BSN | W 26-3 | 44 | 26 | 23 | 4 | 3 | 1 | 11 | 2 | 3 | 6 | 57 | 36 | 8 | 0 | .523 | .632 | .818 | 1.450 | |||||
| 23 |  | Pirates | 23 | 8/1/1893 |  PIT | @ |  STL | W 25-2 | 25 | ||||||||||||||||||||||
| 24 | | Colts | 23 | 8/25/1891 | CHI | vs | BKN | W 28-5 | 28 | ||||||||||||||||||||||
| 25 | | Red Stockings | 23 | 7/6/1883 | CIN | vs | BAL | W 23-0 | 23 | ||||||||||||||||||||||
Some of the information used here was obtained free of charge from Retrosheet.
Brewers 
Mets 
Tigers 
Guardians 
Mariners 
Astros 
WSH 
AZ 
MIA 
SDP 
