The Baltimore Orioles had the lowest run differential per game by a team in 2021, with -1.83.

	TEAM	DIFF/G	DIFF	G	SEASON	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	-1.83	-297	162	2021	.321	52	110	5,420	659	1,296	266	15	195	632	451	65	1,454	54	23	5,981	2,177	476	14	31	12	105	.239	.304	.402	.705
2	Pirates	-1.38	-224	162	2021	.377	61	101	5,336	609	1,261	240	35	124	570	529	49	1,328	60	30	5,982	1,943	399	31	37	24	102	.236	.309	.364	.673
3	Diamondbacks	-1.32	-214	162	2021	.321	52	110	5,489	679	1,297	308	31	144	644	537	54	1,465	43	16	6,140	2,099	483	32	28	24	99	.236	.309	.382	.692
4	Rangers	-1.17	-190	162	2021	.370	60	102	5,405	625	1,254	225	24	167	598	433	58	1,381	106	29	5,943	2,028	416	16	31	10	113	.232	.294	.375	.670
5	Cubs	-0.83	-134	162	2021	.438	71	91	5,306	705	1,255	225	26	210	672	502	92	1,596	86	37	5,970	2,162	461	40	30	17	133	.237	.312	.407	.719
6	Twins	-0.65	-105	162	2021	.451	73	89	5,431	729	1,311	271	17	228	690	525	70	1,405	54	15	6,075	2,300	516	7	42	17	122	.241	.314	.423	.738
7	Royals	-0.63	-102	162	2021	.457	74	88	5,427	686	1,349	251	29	163	647	421	55	1,258	124	33	5,986	2,147	443	31	52	8	100	.249	.306	.396	.702
8	Nationals	-0.59	-96	162	2021	.401	65	97	5,385	724	1,388	272	20	182	686	573	84	1,303	56	26	6,111	2,246	474	38	31	43	158	.258	.337	.417	.754
9	Angels	-0.5	-81	162	2021	.475	77	85	5,437	723	1,331	265	23	190	691	464	59	1,394	79	26	6,015	2,212	478	30	25	35	107	.245	.310	.407	.717
10	Marlins	-0.48	-78	162	2021	.414	67	95	5,348	623	1,244	226	23	158	594	450	65	1,553	106	29	5,923	1,990	407	30	30	25	95	.233	.298	.372	.671
11	Tigers	-0.36	-59	162	2021	.475	77	85	5,376	697	1,299	236	37	179	675	490	44	1,514	88	25	5,977	2,146	452	17	50	8	113	.242	.308	.399	.707
12	Rockies	-0.35	-57	161	2021	.460	74	87	5,374	739	1,338	275	34	182	709	491	58	1,356	76	23	6,007	2,227	491	48	36	24	98	.249	.317	.414	.731
13	Mariners	-0.31	-51	162	2021	.556	90	72	5,355	697	1,209	233	11	199	673	535	72	1,492	64	24	6,007	2,061	443	9	36	8	92	.226	.303	.385	.688
14	Mets	-0.2	-32	162	2021	.475	77	85	5,210	636	1,243	228	18	176	604	495	94	1,392	54	26	5,856	2,035	422	34	23	25	123	.239	.315	.391	.705
15	Phillies	-0.07	-11	162	2021	.506	82	80	5,366	734	1,288	262	24	198	700	564	67	1,402	77	19	6,087	2,192	484	47	43	37	103	.240	.318	.408	.726
16	Indians	-0.06	-10	162	2021	.494	80	82	5,332	717	1,269	248	22	203	686	453	64	1,387	109	17	5,905	2,170	473	20	36	18	105	.238	.303	.407	.710
17	Padres	0.13	21	162	2021	.488	79	83	5,384	729	1,305	273	21	180	695	586	61	1,324	110	39	6,113	2,160	474	36	46	42	121	.242	.321	.401	.722
18	Reds	0.16	26	162	2021	.512	83	79	5,423	786	1,352	295	13	222	756	553	105	1,425	36	24	6,161	2,339	530	35	45	22	129	.249	.328	.431	.759
19	Cardinals	0.21	34	162	2021	.556	90	72	5,351	706	1,303	261	22	198	678	478	86	1,341	89	22	5,999	2,202	481	40	44	32	99	.244	.313	.412	.725
20	Yankees	0.26	42	162	2021	.568	92	70	5,331	711	1,266	213	12	222	666	621	63	1,482	63	18	6,059	2,169	447	10	34	14	154	.237	.322	.407	.729
21	Athletics	0.35	56	162	2021	.531	86	76	5,395	743	1,284	271	19	199	698	545	98	1,349	88	20	6,104	2,190	489	17	49	17	99	.238	.317	.406	.723
22	Red Sox	0.49	80	162	2021	.568	92	70	5,495	829	1,434	330	23	219	783	512	61	1,386	40	21	6,120	2,467	572	10	42	22	100	.261	.328	.449	.777
23	Brewers	0.71	115	162	2021	.586	95	67	5,362	738	1,251	255	18	194	700	586	88	1,465	82	21	6,096	2,124	467	25	35	26	102	.233	.317	.396	.713
24	Braves	0.83	134	161	2021	.547	88	73	5,363	790	1,307	269	20	239	762	549	67	1,453	59	19	6,054	2,333	528	32	43	36	81	.244	.319	.435	.754
25	White Sox	0.99	160	162	2021	.574	93	69	5,357	796	1,373	275	22	190	757	586	78	1,389	57	20	6,084	2,262	487	24	39	10	139	.256	.336	.422	.758