Since 1901, the Philadelphia Phillies have the lowest run differential by a team, with a differential of -6,265 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-6,265	19,351	.469	9,038	10,239	658,455	82,239	170,093	29,720	5,369	13,586	75,826	60,746	4,591	102,032	11,385	2,918	737,945	251,309	48,675	11,135	3,018	3,741	9,873	.258	.324	.382	.706
2	Orioles	-5,440	19,380	.475	9,147	10,123	658,297	83,675	169,865	29,361	4,914	14,452	77,362	63,343	4,483	98,516	10,572	2,785	739,765	252,410	48,727	10,532	3,110	2,576	10,858	.258	.326	.383	.709
3	Twins	-3,217	19,390	.482	9,295	9,986	661,463	85,264	173,465	29,786	6,335	12,040	78,502	62,426	5,174	94,629	12,022	3,083	742,423	252,041	48,161	10,190	3,170	2,664	10,987	.262	.329	.381	.710
4	Athletics	-3,137	19,345	.486	9,355	9,903	655,721	85,380	168,782	29,242	5,334	14,165	78,682	64,592	4,739	99,233	12,122	3,208	738,842	251,187	48,741	10,683	3,107	2,272	10,638	.257	.327	.383	.710
5	Padres	-2,847	8,913	.467	4,165	4,746	301,302	36,125	75,122	13,291	1,764	7,275	33,970	28,681	2,130	59,619	6,020	2,607	338,084	113,766	22,330	3,717	2,254	2,687	6,511	.249	.317	.378	.694
6	Marlins	-2,252	5,078	.458	2,328	2,750	172,607	21,356	43,967	8,368	984	4,621	20,250	15,605	1,837	38,428	3,265	1,301	193,051	68,166	13,973	1,722	1,280	1,203	3,814	.255	.321	.395	.716
7	Royals	-2,177	8,901	.477	4,242	4,657	304,460	38,904	79,960	14,942	2,292	7,018	36,718	26,038	2,465	52,258	7,103	2,903	338,012	120,540	24,252	2,374	2,675	1,870	6,792	.263	.323	.396	.719
8	Rangers	-2,072	10,194	.476	4,850	5,338	347,968	45,849	89,723	15,989	1,893	10,216	43,324	32,941	2,705	65,348	5,964	2,853	389,414	140,146	28,098	2,964	2,836	2,252	7,802	.258	.324	.403	.727
9	Rockies	-1,947	5,086	.459	2,333	2,753	174,654	25,120	47,156	9,316	1,316	5,743	23,889	16,027	1,586	37,886	3,064	1,373	195,632	76,333	16,375	2,005	1,360	1,209	3,876	.270	.335	.437	.772
10	Mariners	-1,673	7,618	.477	3,632	3,984	259,881	33,809	66,770	12,442	1,260	7,752	32,121	24,626	2,359	49,914	5,041	2,174	290,893	104,988	21,454	1,949	2,078	1,666	5,693	.257	.324	.404	.728
11	Braves	-1,583	19,376	.491	9,457	9,812	658,756	81,729	169,556	27,993	4,785	14,175	75,522	59,852	4,390	97,128	10,339	3,070	737,769	249,644	46,953	11,889	2,882	3,658	10,394	.257	.322	.379	.701
12	Nationals	-1,486	8,905	.483	4,295	4,606	301,158	37,299	76,401	14,748	1,792	7,620	35,059	28,298	2,638	57,313	6,557	2,784	338,263	117,593	24,160	3,880	2,289	2,882	6,515	.254	.321	.390	.711
13	Brewers	-798	8,911	.488	4,344	4,563	302,467	39,604	77,430	14,430	1,757	8,727	37,522	29,118	2,718	59,094	6,008	2,737	339,889	121,555	24,914	3,166	2,420	2,160	6,618	.256	.324	.402	.726
14	Mets	-735	10,040	.484	4,860	5,172	339,681	41,441	84,878	15,165	1,819	8,613	39,026	32,484	2,877	65,112	5,907	2,737	381,657	129,520	25,597	3,989	2,626	3,145	7,477	.250	.318	.381	.700
15	Angels	-708	10,206	.495	5,054	5,149	346,262	44,169	88,579	15,314	1,812	9,245	41,563	32,370	2,835	62,931	6,056	3,105	387,784	135,252	26,371	3,540	2,777	2,485	7,887	.256	.322	.391	.713
16	Reds	-607	19,407	.498	9,629	9,688	658,940	83,633	171,184	29,250	5,934	13,736	77,254	59,829	4,793	99,337	13,797	3,412	738,513	253,510	48,920	11,908	3,043	3,649	9,731	.260	.325	.385	.709
17	Rays	-427	4,338	.490	2,127	2,211	147,472	19,287	37,417	7,461	850	4,523	18,347	14,024	1,684	33,588	3,245	1,232	165,082	60,147	12,834	741	1,161	688	3,035	.254	.323	.408	.731
18	Diamondbacks	-289	4,340	.489	2,121	2,219	148,076	19,851	37,732	7,743	1,071	4,643	18,919	14,430	1,431	32,772	2,517	906	166,476	61,546	13,457	1,329	1,210	1,093	3,098	.255	.325	.416	.740
19	Terrapins	-193	314	.425	131	177	10,180	1,195	2,609	418	120	68	1,016	957	83	1,184	280		11,579	3,471	606	359				.256	.325	.341	.666
20	White Sox	-152	19,377	.499	9,617	9,657	656,065	84,150	170,326	28,245	5,552	12,302	77,353	62,170	5,250	92,244	13,635	3,489	739,086	246,581	46,099	12,373	3,228	2,462	10,531	.260	.327	.376	.703
21	Orioles	-122	276	.435	118	153	9,349	1,476	2,666	381	218	57	1,231	786	106	797	396		10,459	3,654	656	218				.285	.347	.391	.738
22	Packers	-43	307	.487	148	156	10,064	1,191	2,575	426	143	67	1,040	767	82	1,091	315		11,264	3,488	636	351				.256	.314	.347	.660
23	Blues	-42	308	.508	154	149	10,129	1,194	2,525	370	142	77	1,014	850	42	1,329	412		11,287	3,410	589	266				.249	.310	.337	.647
24	Tip-Tops	-41	310	.480	147	159	10,256	1,309	2,750	430	160	78	1,134	877	92	1,223	469		11,516	3,734	668	291				.268	.331	.364	.695
25	Terriers	-26	313	.489	149	156	10,223	1,199	2,598	392	146	49	1,026	1,079	70	1,150	308		11,783	3,429	587	411				.254	.329	.335	.665