Luis Castillo has a record of 7-6 with an ERA of 3.60 and 107 strikeouts in 18 appearances versus the Cubs in his career.
| NAME | DATE | TM | OPP | DEC | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 8/15/2017 |  CIN | @ |  CHC | 1 | 0.00 | 7 | 0 | 0 | 0 | 6.0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 22 | 0 | |
| 2 | | L. Castillo | 5/19/2018 | CIN | vs | CHC | 1 | 1.80 | 4 | 0 | 0 | 0 | 5.0 | 6 | 1 | 1 | 0 | 5 | 0 | 0 | 1 | 25 | 0 | |
| 3 | | L. Castillo | 6/22/2018 | CIN | vs | CHC | W | 1 | 4.76 | 5 | 0 | 0 | 0 | 5.2 | 4 | 3 | 3 | 1 | 1 | 1 | 0 | 0 | 23 | 0 |
| 4 | | L. Castillo | 7/8/2018 | CIN | @ | CHC | 1 | 6.75 | 3 | 0 | 0 | 0 | 4.0 | 6 | 3 | 3 | 0 | 2 | 0 | 0 | 0 | 19 | 0 | |
| 5 | | L. Castillo | 8/25/2018 | CIN | @ | CHC | L | 1 | 13.50 | 2 | 0 | 0 | 0 | 3.1 | 5 | 5 | 5 | 2 | 1 | 1 | 0 | 0 | 17 | 0 |
| 6 | | L. Castillo | 9/16/2018 | CIN | @ | CHC | W | 1 | 1.35 | 2 | 0 | 0 | 0 | 6.2 | 4 | 1 | 1 | 0 | 4 | 1 | 0 | 0 | 27 | 0 |
| 7 | | L. Castillo | 5/16/2019 | CIN | vs | CHC | W | 1 | 3.38 | 6 | 0 | 0 | 0 | 5.1 | 2 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 19 | 0 |
| 8 | | L. Castillo | 6/29/2019 | CIN | vs | CHC | L | 1 | 1.29 | 6 | 0 | 0 | 0 | 7.0 | 3 | 1 | 1 | 1 | 3 | 0 | 0 | 0 | 26 | 0 |
| 9 | | L. Castillo | 7/15/2019 | CIN | @ | CHC | W | 1 | 4.50 | 10 | 0 | 0 | 0 | 6.0 | 7 | 3 | 3 | 1 | 3 | 0 | 0 | 0 | 27 | 1 |
| 10 | | L. Castillo | 8/11/2019 | CIN | vs | CHC | 1 | 4.05 | 8 | 0 | 0 | 0 | 6.2 | 7 | 3 | 3 | 0 | 1 | 0 | 0 | 0 | 28 | 0 | |
| 11 | | L. Castillo | 8/30/2020 | CIN | vs | CHC | L | 1 | 7.20 | 7 | 0 | 0 | 0 | 5.0 | 5 | 4 | 4 | 3 | 1 | 1 | 0 | 0 | 22 | 0 |
| 12 | | L. Castillo | 5/1/2021 | CIN | vs | CHC | L | 1 | 5.06 | 5 | 0 | 0 | 0 | 5.1 | 8 | 3 | 3 | 0 | 1 | 0 | 0 | 0 | 23 | 0 |
| 13 | | L. Castillo | 5/29/2021 | CIN | @ | CHC | L | 1 | 3.60 | 3 | 0 | 0 | 0 | 5.0 | 4 | 2 | 4 | 0 | 4 | 1 | 0 | 0 | 23 | 0 |
| 14 | | L. Castillo | 7/29/2021 | CIN | @ | CHC | W | 1 | 4.50 | 8 | 0 | 0 | 0 | 6.0 | 7 | 3 | 3 | 2 | 2 | 0 | 0 | 0 | 24 | 0 |
| 15 | | L. Castillo | 5/25/2022 | CIN | vs | CHC | W | 1 | 3.60 | 6 | 0 | 0 | 0 | 5.0 | 4 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 20 | 0 |
| 16 | | L. Castillo | 6/28/2022 | CIN | @ | CHC | W | 1 | 0.00 | 11 | 0 | 0 | 0 | 6.0 | 5 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 25 | 0 |
| 17 |  | L. Castillo | 4/10/2023 |  SEA | @ | CHC | 1 | 3.00 | 5 | 0 | 0 | 0 | 6.0 | 6 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 25 | 0 | |
| 18 | | L. Castillo | 4/14/2024 | SEA | vs | CHC | L | 1 | 3.00 | 9 | 0 | 0 | 0 | 6.0 | 7 | 2 | 3 | 1 | 0 | 0 | 0 | 0 | 24 | 0 |
| Total | 18 | 3.60 | 107 | 0 | 0 | 0 | 100.0 | 92 | 40 | 43 | 11 | 37 | 5 | 0 | 1 | 419 | 1 |
Some of the information used here was obtained free of charge from Retrosheet.
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