Luis Castillo has played 10 seasons for the Reds, Mariners and White Sox. He has 87 wins, 95 losses, an ERA of 3.73 and 1,604 strikeouts.
- Regular season
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 2017 | 15 | 3 | 7 | .300 | 15 | 3.12 | 98 | 0 | 0 | 0 | 89.1 | 64 | 31 | 32 | 11 | 32 | 3 | 0 | 1 | 359 | 2 | 9.87 | 3.22 | 3.06 | 1.11 | 27.3 | 8.9 | 1.07 | .247 | 3.22 | 71 | 3.73 | 85 | 6.45 | 6.6 | |
| 2 | | L. Castillo | 2018 | 31 | 10 | 12 | .455 | 31 | 4.30 | 165 | 0 | 0 | 0 | 169.2 | 158 | 81 | 89 | 28 | 49 | 5 | 0 | 1 | 708 | 4 | 8.75 | 2.60 | 3.37 | 1.49 | 23.3 | 6.9 | 1.22 | .282 | 4.72 | 105 | 4.31 | 103 | 8.38 | -2.2 | |
| 3 | | L. Castillo | 2019 | 32 | 15 | 8 | .652 | 32 | 3.40 | 226 | 0 | 0 | 0 | 190.2 | 139 | 72 | 76 | 22 | 79 | 7 | 0 | 0 | 781 | 5 | 10.67 | 3.73 | 2.86 | 1.04 | 28.9 | 10.1 | 1.14 | .262 | 3.59 | 74 | 3.69 | 80 | 6.56 | 19 | |
| 4 | | L. Castillo | 2020 | 12 | 4 | 6 | .400 | 12 | 3.21 | 89 | 1 | 0 | 0 | 70.0 | 62 | 25 | 31 | 5 | 24 | 1 | 0 | 0 | 292 | 1 | 11.44 | 3.09 | 3.71 | 0.64 | 30.5 | 8.2 | 1.23 | .329 | 3.99 | 68 | 2.64 | 57 | 7.97 | 15.2 | |
| 5 | | L. Castillo | 2021 | 33 | 8 | 16 | .333 | 33 | 3.98 | 192 | 0 | 0 | 0 | 187.2 | 181 | 83 | 94 | 19 | 75 | 7 | 0 | 4 | 803 | 1 | 9.21 | 3.60 | 2.56 | 0.91 | 23.9 | 9.3 | 1.36 | .318 | 4.51 | 90 | 3.74 | 84 | 8.68 | 14.5 | |
| 6 |  | L. Castillo | 2022 | TOT | 25 | 8 | 6 | .571 | 25 | 2.99 | 167 | 0 | 0 | 0 | 150.1 | 118 | 50 | 56 | 13 | 45 | 8 | 0 | 0 | 615 | 0 | 10.00 | 2.69 | 3.71 | 0.78 | 27.2 | 7.3 | 1.08 | .275 | 3.35 | 75 | 3.07 | 76 | 7.06 | 15.9 |
| 7 |  | L. Castillo | 2023 | 33 | 13 | 9 | .591 | 33 | 3.34 | 219 | 0 | 0 | 0 | 197.0 | 160 | 73 | 81 | 28 | 56 | 5 | 0 | 0 | 802 | 3 | 10.01 | 2.56 | 3.91 | 1.28 | 27.3 | 7.0 | 1.10 | .267 | 3.70 | 83 | 3.80 | 93 | 7.31 | 6.6 | |
| 8 | | L. Castillo | 2024 | 30 | 11 | 12 | .478 | 30 | 3.64 | 175 | 0 | 0 | 0 | 175.1 | 158 | 71 | 73 | 25 | 47 | 5 | 0 | 2 | 719 | 0 | 8.98 | 2.41 | 3.72 | 1.28 | 24.3 | 6.5 | 1.17 | .285 | 3.75 | 97 | 3.91 | 100 | 8.11 | 0 | |
| 9 | | L. Castillo | 2025 | 32 | 11 | 8 | .579 | 32 | 3.54 | 162 | 0 | 0 | 0 | 180.2 | 168 | 71 | 76 | 23 | 46 | 7 | 0 | 0 | 745 | 3 | 8.07 | 2.29 | 3.52 | 1.15 | 21.7 | 6.2 | 1.18 | .286 | 3.79 | 93 | 3.87 | 97 | 8.37 | 2.5 | |
| 10 | | L. Castillo | 2026 | TOT | 27 | 4 | 11 | .267 | 23 | 5.67 | 111 | 0 | 0 | 0 | 128.2 | 148 | 81 | 91 | 24 | 43 | 7 | 2 | 2 | 582 | 2 | 7.76 | 3.01 | 2.58 | 1.68 | 19.1 | 7.4 | 1.48 | .312 | 6.37 | 144 | 4.96 | 122 | 10.35 | -13.4 |
| Total | 270 | 87 | 95 | .478 | 266 | 3.73 | 1,604 | 1 | 0 | 0 | 1539.1 | 1,356 | 638 | 699 | 198 | 496 | 55 | 2 | 10 | 6,406 | 21 | 9.38 | 2.90 | 3.23 | 1.16 | 25.0 | 7.7 | 1.20 | .286 | 4.09 | 91 | 3.82 | 91 | 7.93 | 64.6 |
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| NL East | W | L | PCT | GB |
|---|---|---|---|---|
89 | 63 | .586 | ||
83 | 68 | .550 | 5.5 | |
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| NL Central | W | L | PCT | GB |
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75 | 76 | .497 | 19.0 | |
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| NL West | W | L | PCT | GB |
 Dodgers - x | 92 | 59 | .609 | |
82 | 69 | .543 | 10.0 | |
80 | 72 | .526 | 12.5 | |
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