Luis Castillo has a 6-8 record with an ERA of 4.34 and 108 strikeouts in 20 appearances versus the Cardinals in his career.
| NAME | DATE | TM | OPP | DEC | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 8/5/2017 |  CIN | vs |  STL | L | 1 | 4.26 | 4 | 0 | 0 | 0 | 6.1 | 3 | 3 | 4 | 1 | 5 | 2 | 0 | 1 | 27 | 0 |
| 2 | | L. Castillo | 4/22/2018 | CIN | @ | STL | L | 1 | 5.40 | 3 | 0 | 0 | 0 | 5.0 | 7 | 3 | 3 | 1 | 4 | 0 | 0 | 0 | 24 | 0 |
| 3 | | L. Castillo | 6/9/2018 | CIN | vs | STL | L | 1 | 7.50 | 10 | 0 | 0 | 0 | 6.0 | 4 | 5 | 5 | 2 | 3 | 0 | 0 | 0 | 25 | 0 |
| 4 | | L. Castillo | 7/14/2018 | CIN | @ | STL | 1 | 3.60 | 2 | 0 | 0 | 0 | 5.0 | 5 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 18 | 0 | |
| 5 | | L. Castillo | 7/23/2018 | CIN | vs | STL | 1 | 1.69 | 5 | 0 | 0 | 0 | 5.1 | 4 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 21 | 0 | |
| 6 | | L. Castillo | 9/1/2018 | CIN | @ | STL | W | 1 | 0.00 | 11 | 0 | 0 | 0 | 6.2 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 24 | 0 |
| 7 | | L. Castillo | 6/4/2019 | CIN | @ | STL | W | 1 | 1.50 | 8 | 0 | 0 | 0 | 6.0 | 2 | 1 | 1 | 1 | 4 | 0 | 0 | 0 | 24 | 0 |
| 8 | | L. Castillo | 7/20/2019 | CIN | vs | STL | 1 | 1.50 | 4 | 0 | 0 | 0 | 6.0 | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 22 | 0 | |
| 9 | | L. Castillo | 8/16/2019 | CIN | vs | STL | L | 1 | 16.62 | 3 | 0 | 0 | 0 | 4.1 | 9 | 8 | 8 | 3 | 0 | 0 | 0 | 0 | 22 | 0 |
| 10 | | L. Castillo | 9/1/2019 | CIN | @ | STL | W | 1 | 4.50 | 8 | 0 | 0 | 0 | 6.0 | 5 | 3 | 3 | 1 | 3 | 0 | 0 | 0 | 25 | 0 |
| 11 | | L. Castillo | 9/11/2020 | CIN | @ | STL | W | 1 | 1.00 | 6 | 1 | 0 | 0 | 9.0 | 2 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 31 | 0 |
| 12 | | L. Castillo | 4/1/2021 | CIN | vs | STL | L | 1 | 21.60 | 0 | 0 | 0 | 0 | 3.1 | 8 | 8 | 10 | 1 | 2 | 1 | 0 | 0 | 21 | 1 |
| 13 | | L. Castillo | 4/25/2021 | CIN | @ | STL | L | 1 | 7.20 | 3 | 0 | 0 | 0 | 5.0 | 6 | 4 | 4 | 2 | 1 | 0 | 0 | 0 | 21 | 0 |
| 14 | | L. Castillo | 6/4/2021 | CIN | @ | STL | W | 1 | 1.50 | 5 | 0 | 0 | 0 | 6.0 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 23 | 0 |
| 15 | | L. Castillo | 7/24/2021 | CIN | vs | STL | W | 1 | 1.29 | 9 | 0 | 0 | 0 | 7.0 | 5 | 1 | 1 | 0 | 3 | 0 | 0 | 1 | 28 | 0 |
| 16 | | L. Castillo | 8/30/2021 | CIN | vs | STL | L | 1 | 4.50 | 8 | 0 | 0 | 0 | 6.0 | 5 | 3 | 3 | 1 | 2 | 0 | 0 | 0 | 24 | 0 |
| 17 | | L. Castillo | 9/11/2021 | CIN | @ | STL | 1 | 5.14 | 5 | 0 | 0 | 0 | 7.0 | 8 | 4 | 4 | 1 | 1 | 0 | 0 | 0 | 27 | 0 | |
| 18 | | L. Castillo | 6/10/2022 | CIN | @ | STL | L | 1 | 1.50 | 3 | 0 | 0 | 0 | 6.0 | 6 | 1 | 2 | 0 | 1 | 1 | 0 | 0 | 26 | 0 |
| 19 |  | L. Castillo | 4/22/2023 |  SEA | vs | STL | 1 | 5.40 | 8 | 0 | 0 | 0 | 5.0 | 7 | 3 | 3 | 0 | 2 | 0 | 0 | 0 | 24 | 0 | |
| 20 | | L. Castillo | 9/8/2024 | SEA | @ | STL | 1 | 6.00 | 3 | 0 | 0 | 0 | 3.0 | 5 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 15 | 0 | |
| Total | 20 | 4.34 | 108 | 1 | 0 | 0 | 114.0 | 101 | 55 | 59 | 17 | 40 | 5 | 0 | 2 | 472 | 1 |
Some of the information used here was obtained free of charge from Retrosheet.
Cubs 
Brewers 
Pirates 
ATL 
HOU 
Mets 
Phillies 
Dodgers 
Padres 
Yankees 
Red Sox 
Tigers 
Guardians 
Athletics 
MIA 
BAL 
WSH 
SFG 
AZ 
