Luis Castillo has played 9 seasons for the Reds and Mariners. He has 76 wins, 81 losses, an ERA of 3.57 and 1,406 strikeouts.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 2017 |  CIN | 15 | 3 | 7 | .300 | 15 | 3.12 | 98 | 0 | 0 | 0 | 89.1 | 64 | 31 | 32 | 11 | 32 | 3 | 0 | 1 | 359 | 2 | 9.87 | 3.22 | 3.06 | 1.11 | 27.3 | 8.9 | 1.07 | .247 | 3.22 | 71 | 3.73 | 85 | 6.45 | 6.6 |
| 2 | | L. Castillo | 2018 | CIN | 31 | 10 | 12 | .455 | 31 | 4.30 | 165 | 0 | 0 | 0 | 169.2 | 158 | 81 | 89 | 28 | 49 | 5 | 0 | 1 | 708 | 4 | 8.75 | 2.60 | 3.37 | 1.49 | 23.3 | 6.9 | 1.22 | .282 | 4.72 | 105 | 4.31 | 103 | 8.38 | -2.2 |
| 3 | | L. Castillo | 2019 | CIN | 32 | 15 | 8 | .652 | 32 | 3.40 | 226 | 0 | 0 | 0 | 190.2 | 139 | 72 | 76 | 22 | 79 | 7 | 0 | 0 | 781 | 5 | 10.67 | 3.73 | 2.86 | 1.04 | 28.9 | 10.1 | 1.14 | .262 | 3.59 | 74 | 3.69 | 80 | 6.56 | 19 |
| 4 | | L. Castillo | 2020 | CIN | 12 | 4 | 6 | .400 | 12 | 3.21 | 89 | 1 | 0 | 0 | 70.0 | 62 | 25 | 31 | 5 | 24 | 1 | 0 | 0 | 292 | 1 | 11.44 | 3.09 | 3.71 | 0.64 | 30.5 | 8.2 | 1.23 | .329 | 3.99 | 68 | 2.64 | 57 | 7.97 | 15.2 |
| 5 | | L. Castillo | 2021 | CIN | 33 | 8 | 16 | .333 | 33 | 3.98 | 192 | 0 | 0 | 0 | 187.2 | 181 | 83 | 94 | 19 | 75 | 7 | 0 | 4 | 803 | 1 | 9.21 | 3.60 | 2.56 | 0.91 | 23.9 | 9.3 | 1.36 | .318 | 4.51 | 90 | 3.74 | 84 | 8.68 | 14.5 |
| 6 |  | L. Castillo | 2022 | TOT | 25 | 8 | 6 | .571 | 25 | 2.99 | 167 | 0 | 0 | 0 | 150.1 | 118 | 50 | 56 | 13 | 45 | 8 | 0 | 0 | 615 | 0 | 10.00 | 2.69 | 3.71 | 0.78 | 27.2 | 7.3 | 1.08 | .275 | 3.35 | 75 | 3.07 | 76 | 7.06 | 15.9 |
| 7 | | L. Castillo | 2023 |  SEA | 33 | 13 | 9 | .591 | 33 | 3.34 | 219 | 0 | 0 | 0 | 197.0 | 160 | 73 | 81 | 28 | 56 | 5 | 0 | 0 | 802 | 3 | 10.01 | 2.56 | 3.91 | 1.28 | 27.3 | 7.0 | 1.10 | .267 | 3.70 | 83 | 3.80 | 93 | 7.31 | 6.6 |
| 8 | | L. Castillo | 2024 | SEA | 30 | 11 | 12 | .478 | 30 | 3.64 | 175 | 0 | 0 | 0 | 175.1 | 158 | 71 | 73 | 25 | 47 | 5 | 0 | 2 | 719 | 0 | 8.98 | 2.41 | 3.72 | 1.28 | 24.3 | 6.5 | 1.17 | .285 | 3.75 | 97 | 3.91 | 100 | 8.11 | 0 |
| 9 | | L. Castillo | 2025 | SEA | 16 | 4 | 5 | .444 | 16 | 3.69 | 75 | 0 | 0 | 0 | 90.1 | 85 | 37 | 39 | 12 | 30 | 2 | 0 | 0 | 381 | 1 | 7.47 | 2.99 | 2.50 | 1.20 | 19.7 | 7.9 | 1.27 | .279 | 3.89 | 98 | 4.19 | 108 | 8.47 | -3.3 |
| Total | 227 | 76 | 81 | .484 | 227 | 3.57 | 1,406 | 1 | 0 | 0 | 1320.1 | 1,125 | 523 | 571 | 163 | 437 | 43 | 0 | 8 | 5,460 | 17 | 9.58 | 2.98 | 3.22 | 1.11 | 25.8 | 8.0 | 1.18 | .282 | 3.89 | 86 | 3.73 | 89 | 7.67 | 72.3 |
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