Luis Castillo has a record of 55-57 with an ERA of 3.49 and 1,004 strikeouts in 165 appearances since 2020.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 2020 |  CIN | 12 | 4 | 6 | .400 | 12 | 3.21 | 89 | 1 | 0 | 0 | 70.0 | 62 | 25 | 31 | 5 | 24 | 1 | 0 | 0 | 292 | 1 | 11.44 | 3.09 | 3.71 | 0.64 | 30.5 | 8.2 | 1.23 | .329 | 3.99 | 68 | 2.64 | 57 | 7.97 | 15.2 |
| 2 | | L. Castillo | 2021 | CIN | 33 | 8 | 16 | .333 | 33 | 3.98 | 192 | 0 | 0 | 0 | 187.2 | 181 | 83 | 94 | 19 | 75 | 7 | 0 | 4 | 803 | 1 | 9.21 | 3.60 | 2.56 | 0.91 | 23.9 | 9.3 | 1.36 | .318 | 4.51 | 90 | 3.74 | 84 | 8.68 | 14.5 |
| 3 |  | L. Castillo | 2022 | TOT | 25 | 8 | 6 | .571 | 25 | 2.99 | 167 | 0 | 0 | 0 | 150.1 | 118 | 50 | 56 | 13 | 45 | 8 | 0 | 0 | 615 | 0 | 10.00 | 2.69 | 3.71 | 0.78 | 27.2 | 7.3 | 1.08 | .275 | 3.35 | 75 | 3.07 | 76 | 7.06 | 15.9 |
| 4 | | L. Castillo | 2023 |  SEA | 33 | 13 | 9 | .591 | 33 | 3.34 | 219 | 0 | 0 | 0 | 197.0 | 160 | 73 | 81 | 28 | 56 | 5 | 0 | 0 | 802 | 3 | 10.01 | 2.56 | 3.91 | 1.28 | 27.3 | 7.0 | 1.10 | .267 | 3.70 | 83 | 3.80 | 93 | 7.31 | 6.6 |
| 5 | | L. Castillo | 2024 | SEA | 30 | 11 | 12 | .478 | 30 | 3.64 | 175 | 0 | 0 | 0 | 175.1 | 158 | 71 | 73 | 25 | 47 | 5 | 0 | 2 | 719 | 0 | 8.98 | 2.41 | 3.72 | 1.28 | 24.3 | 6.5 | 1.17 | .285 | 3.75 | 97 | 3.91 | 100 | 8.11 | 0 |
| 6 | | L. Castillo | 2025 | SEA | 32 | 11 | 8 | .579 | 32 | 3.54 | 162 | 0 | 0 | 0 | 180.2 | 168 | 71 | 76 | 23 | 46 | 7 | 0 | 0 | 745 | 3 | 8.07 | 2.29 | 3.52 | 1.15 | 21.7 | 6.2 | 1.18 | .286 | 3.79 | 92 | 3.87 | 97 | 8.37 | 2.5 |
| Total | 165 | 55 | 57 | .491 | 165 | 3.49 | 1,004 | 1 | 0 | 0 | 961.0 | 847 | 373 | 411 | 113 | 293 | 33 | 0 | 6 | 3,976 | 8 | 9.40 | 2.74 | 3.43 | 1.06 | 25.3 | 7.4 | 1.19 | .290 | 3.85 | 86 | 3.62 | 88 | 7.93 | 54.7 |
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