Luis Castillo has a record of 39-31 with an ERA of 3.46 and 633 strikeouts in 106 appearances for the Mariners in his career.
| NAME | SEASON | TM | G | W | L | W% | GS | ERA | SO | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. Castillo | 2022 |  SEA | 11 | 4 | 2 | .667 | 11 | 3.17 | 77 | 0 | 0 | 0 | 65.1 | 55 | 23 | 26 | 6 | 17 | 4 | 0 | 0 | 266 | 0 | 10.61 | 2.34 | 4.53 | 0.83 | 28.9 | 6.4 | 1.10 | .302 | 3.58 | 85 | 2.91 | 76 | 7.58 | 6.7 |
| 2 | | L. Castillo | 2023 | SEA | 33 | 13 | 9 | .591 | 33 | 3.34 | 219 | 0 | 0 | 0 | 197.0 | 160 | 73 | 81 | 28 | 56 | 5 | 0 | 0 | 802 | 3 | 10.01 | 2.56 | 3.91 | 1.28 | 27.3 | 7.0 | 1.10 | .267 | 3.70 | 83 | 3.80 | 93 | 7.31 | 6.6 |
| 3 | | L. Castillo | 2024 | SEA | 30 | 11 | 12 | .478 | 30 | 3.64 | 175 | 0 | 0 | 0 | 175.1 | 158 | 71 | 73 | 25 | 47 | 5 | 0 | 2 | 719 | 0 | 8.98 | 2.41 | 3.72 | 1.28 | 24.3 | 6.5 | 1.17 | .285 | 3.75 | 97 | 3.91 | 100 | 8.11 | 0 |
| 4 | | L. Castillo | 2025 | SEA | 32 | 11 | 8 | .579 | 32 | 3.54 | 162 | 0 | 0 | 0 | 180.2 | 168 | 71 | 76 | 23 | 46 | 7 | 0 | 0 | 745 | 3 | 8.07 | 2.29 | 3.52 | 1.15 | 21.7 | 6.2 | 1.18 | .286 | 3.79 | 92 | 3.87 | 97 | 8.37 | 2.5 |
| Total | 106 | 39 | 31 | .557 | 106 | 3.46 | 633 | 0 | 0 | 0 | 618.1 | 541 | 238 | 256 | 82 | 166 | 21 | 0 | 2 | 2,532 | 6 | 9.21 | 2.42 | 3.81 | 1.19 | 25.0 | 6.6 | 1.14 | .282 | 3.73 | 90 | 3.76 | 94 | 7.87 | 15.9 |
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