The Philadelphia Phillies have the lowest run differential by a team, with a differential of -5,714 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-5,714	21,717	.474	10,247	11,355	743,081	96,433	193,486	33,449	6,681	14,214	86,652	67,810	5,421	105,513	14,980	2,918	831,250	282,939	54,344	11,919	3,019	3,741	9,873	.260	.326	.381	.706
2	Orioles	-5,441	19,382	.475	9,148	10,124	658,356	83,678	169,875	29,362	4,914	14,455	77,365	63,349	4,483	98,530	10,572	2,785	739,830	252,430	48,731	10,532	3,110	2,577	10,861	.258	.326	.383	.709
3	Twins	-3,230	19,391	.482	9,295	9,987	661,498	85,267	173,473	29,788	6,335	12,040	78,505	62,429	5,174	94,638	12,022	3,083	742,461	252,051	48,163	10,190	3,170	2,664	10,987	.262	.329	.381	.710
4	Athletics	-3,137	19,345	.486	9,355	9,903	655,721	85,380	168,782	29,242	5,334	14,165	78,682	64,592	4,739	99,233	12,122	3,208	738,842	251,187	48,741	10,683	3,107	2,272	10,638	.257	.327	.383	.710
5	Padres	-2,847	8,913	.467	4,165	4,746	301,302	36,125	75,122	13,291	1,764	7,275	33,970	28,681	2,130	59,619	6,020	2,607	338,084	113,766	22,330	3,717	2,254	2,687	6,511	.249	.317	.378	.694
6	Marlins	-2,250	5,079	.459	2,329	2,750	172,647	21,367	43,984	8,370	984	4,623	20,261	15,610	1,837	38,434	3,265	1,302	193,097	68,191	13,977	1,722	1,281	1,203	3,815	.255	.321	.395	.716
7	Royals	-2,178	8,902	.477	4,242	4,658	304,491	38,904	79,965	14,942	2,293	7,018	36,718	26,040	2,465	52,263	7,103	2,903	338,045	120,547	24,253	2,374	2,675	1,870	6,793	.263	.323	.396	.719
8	Rangers	-2,059	10,195	.476	4,851	5,338	348,011	45,865	89,740	15,990	1,893	10,222	43,339	32,950	2,706	65,353	5,965	2,853	389,467	140,182	28,105	2,964	2,836	2,252	7,802	.258	.324	.403	.727
9	Rockies	-1,957	5,089	.459	2,334	2,755	174,766	25,139	47,193	9,322	1,317	5,746	23,907	16,040	1,588	37,908	3,065	1,373	195,760	76,387	16,385	2,005	1,361	1,209	3,881	.270	.335	.437	.772
10	Colonels	-1,890	2,355	.429	993	1,320	82,256	12,464	21,505	2,816	1,292	436	8,508	6,080	757	3,638	3,474		89,787	28,213	4,544	609				.261	.319	.343	.662
11	Senators	-1,865	1,265	.366	454	788	43,645	6,912	11,886	1,615	787	357	5,764	4,269	575	3,492	1,975		48,963	16,146	2,759	474				.272	.345	.370	.715
12	Mariners	-1,673	7,618	.477	3,632	3,984	259,881	33,809	66,770	12,442	1,260	7,752	32,121	24,626	2,359	49,914	5,041	2,174	290,893	104,988	21,454	1,949	2,078	1,666	5,693	.257	.324	.404	.728
13	Nationals	-1,489	8,907	.482	4,295	4,608	301,234	37,311	76,424	14,749	1,792	7,621	35,070	28,302	2,639	57,330	6,557	2,784	338,344	117,620	24,162	3,880	2,289	2,882	6,516	.254	.321	.390	.711
14	Nationals	-1,080	514	.326	163	337	17,337	2,160	3,944	533	220	125	1,647	1,246	127		1,040		18,710	5,292	878					.227	.284	.305	.589
15	Orioles	-802	944	.437	403	519	32,654	4,964	7,699	1,083	504	136	2,635	2,289	208		1,451		35,293	10,198	1,723					.236	.293	.312	.605
16	Brewers	-792	8,912	.488	4,345	4,563	302,500	39,610	77,442	14,431	1,758	8,728	37,528	29,119	2,718	59,098	6,008	2,737	339,923	121,573	24,917	3,166	2,420	2,160	6,620	.256	.325	.402	.726
17	Mets	-734	10,041	.485	4,861	5,172	339,711	41,445	84,885	15,167	1,819	8,615	39,030	32,489	2,878	65,118	5,909	2,738	381,693	129,535	25,601	3,989	2,626	3,145	7,478	.250	.318	.381	.700
18	Angels	-710	10,207	.495	5,054	5,150	346,295	44,169	88,587	15,314	1,812	9,245	41,563	32,371	2,835	62,946	6,058	3,105	387,818	135,260	26,371	3,540	2,777	2,485	7,889	.256	.322	.391	.713
19	Spiders	-672	1,802	.469	827	938	63,232	10,057	17,006	2,308	961	292	8,238	5,871	580	3,144	2,800		70,233	22,112	3,561	550				.269	.337	.350	.686
20	Reds	-638	348	.365	125	217	12,768	1,643	3,191	408	157	30		318					13,086	4,003	595					.250		.314
21	Hoosiers	-540	398	.370	146	249	13,870	2,050	3,536	570	138	129	1,577	913	131		936		14,914	4,769	837					.255	.307	.344	.651
22	Cowboys	-496	271	.364	98	171	9,535	1,431	2,256	304	137	37	1,052	718	123		729		10,376	2,945	478					.237	.298	.309	.607
23	Rays	-427	4,338	.490	2,127	2,211	147,472	19,287	37,417	7,461	850	4,523	18,347	14,024	1,684	33,588	3,245	1,232	165,082	60,147	12,834	741	1,161	688	3,035	.254	.323	.408	.731
24	Bisons	-406	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
25	Trojans	-388	330	.412	134	191	11,951	1,542	2,929	456	151	26		414					12,365	3,765	633					.245		.315