The Baltimore Orioles had the highest run differential by a team in 1980, with a differential of 165 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Orioles	165	1980	162	.617	100	62	5,585	805	1,523	258	29	156	751	587	21	766	111	38	6,281	2,307	443	42	46	38	158	.273	.342	.413	.755
2	Yankees	158	1980	162	.636	103	59	5,553	820	1,484	239	34	189	772	643	28	739	86	36	6,329	2,358	462	51	54	58	136	.267	.343	.425	.768
3	Brewers	129	1980	162	.531	86	76	5,653	811	1,555	298	36	203	774	455	25	745	131	56	6,242	2,534	537	58	51	59	98	.275	.329	.448	.777
4	Royals	115	1980	162	.599	97	65	5,714	809	1,633	266	59	115	766	508	38	709	185	43	6,357	2,362	440	34	63	45	147	.286	.345	.413	.758
5	Phillies	89	1980	162	.562	91	71	5,625	728	1,517	272	54	117	674	472	33	708	140	62	6,265	2,248	443	77	58	65	120	.270	.327	.400	.726
6	Tigers	73	1980	163	.519	84	78	5,648	830	1,543	232	53	143	767	645	33	844	75	68	6,444	2,310	428	63	55	35	144	.273	.348	.409	.757
7	Dodgers	72	1980	163	.564	92	71	5,568	663	1,462	209	24	148	638	492	24	846	123	72	6,221	2,163	381	96	41	52	108	.263	.323	.388	.711
8	Expos	65	1980	162	.556	90	72	5,465	694	1,407	250	61	114	647	547	20	865	237	82	6,164	2,121	425	76	56	75	102	.257	.324	.388	.712
9	Astros	48	1980	163	.571	93	70	5,566	637	1,455	231	67	75	599	540	13	755	194	74	6,253	2,045	373	89	45	73	96	.261	.326	.367	.693
10	Athletics	44	1980	162	.512	83	79	5,495	686	1,424	212	35	137	635	506	19	824	175	82	6,160	2,117	384	99	41	49	124	.259	.322	.385	.707
11	Reds	37	1980	163	.549	89	73	5,516	707	1,445	256	45	113	668	537	23	852	156	43	6,208	2,130	414	78	54	68	116	.262	.327	.386	.713
12	Cardinals	28	1980	162	.457	74	88	5,608	738	1,541	300	49	101	688	451	21	781	117	54	6,202	2,242	450	73	49	74	141	.275	.328	.400	.728
13	Pirates	20	1980	162	.512	83	79	5,517	666	1,469	249	38	116	626	452	25	760	209	102	6,125	2,142	403	75	56	85	107	.266	.322	.388	.710
14	Rangers	4	1980	163	.472	76	85	5,690	756	1,616	263	27	124	720	480	23	589	91	49	6,319	2,305	414	70	56	51	156	.284	.339	.405	.744
15	Red Sox	-10	1980	160	.519	83	77	5,603	757	1,588	297	36	162	717	475	32	720	79	48	6,200	2,443	495	40	50	48	151	.283	.340	.436	.776
16	Braves	-30	1980	161	.503	81	80	5,402	630	1,352	226	22	144	597	434	20	899	73	52	5,958	2,054	392	69	33	49	124	.250	.307	.380	.687
17	Twins	-54	1980	161	.478	77	84	5,530	670	1,468	252	46	99	634	436	21	703	62	46	6,130	2,109	397	92	51	40	151	.265	.319	.381	.700
18	Giants	-61	1980	161	.466	75	86	5,368	573	1,310	199	44	80	539	509	14	840	100	58	6,045	1,837	323	100	54	61	122	.244	.308	.342	.651
19	Padres	-63	1980	163	.451	73	89	5,540	591	1,410	195	43	67	546	563	21	791	239	73	6,254	1,892	305	92	38	70	113	.255	.324	.342	.665
20	Indians	-69	1980	160	.494	79	81	5,470	738	1,517	221	40	89	692	617	37	625	118	58	6,258	2,085	350	60	74	51	165	.277	.350	.381	.731
21	Mets	-91	1980	162	.414	67	95	5,478	611	1,407	218	41	61	554	501	25	840	158	99	6,130	1,890	320	73	53	63	126	.257	.319	.345	.664
22	Angels	-99	1980	160	.406	65	95	5,443	698	1,442	236	32	106	655	539	32	889	91	63	6,134	2,060	374	71	49	38	141	.265	.332	.378	.710
23	Cubs	-114	1980	162	.395	64	98	5,619	614	1,411	251	35	107	578	471	18	912	93	64	6,217	2,053	393	69	40	54	119	.251	.309	.365	.674
24	White Sox	-135	1980	162	.438	70	90	5,444	587	1,408	255	38	91	547	399	39	670	68	54	6,000	2,012	384	67	51	46	142	.259	.311	.370	.681
25	Blue Jays	-138	1980	162	.414	67	95	5,571	624	1,398	249	53	126	580	448	33	813	67	72	6,149	2,131	428	63	34	44	119	.251	.309	.383	.691