Between the 2003 and 2022 seasons, the New York Yankees had the highest run differential by a team, with a differential of 2,340 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,340	3,139	.582	1,825	1,313	107,296	16,004	28,154	5,294	401	4,274	15,324	11,578	1,283	22,895	1,862	565	121,530	47,072	9,969	500	873	589	2,535	.262	.339	.439	.778
2	Dodgers	2,093	3,138	.566	1,777	1,361	106,513	14,248	27,417	5,375	553	3,343	13,567	10,692	1,174	22,917	1,790	679	120,237	43,927	9,271	1,061	797	862	2,363	.257	.330	.412	.742
3	Red Sox	1,753	3,138	.550	1,726	1,412	109,113	16,182	29,511	6,583	494	3,727	15,409	11,250	1,112	23,023	1,623	525	122,822	48,263	10,804	378	969	778	2,540	.270	.342	.442	.784
4	Cardinals	1,586	3,135	.555	1,740	1,395	106,644	14,644	28,003	5,565	477	3,359	13,930	10,303	1,257	22,058	1,434	627	120,187	44,599	9,401	1,112	871	910	2,501	.263	.332	.418	.750
5	Braves	1,130	3,136	.534	1,675	1,461	107,072	14,461	27,730	5,618	488	3,435	13,821	10,500	1,010	23,834	1,447	589	120,467	44,629	9,541	1,118	767	863	2,399	.259	.329	.417	.746
6	Guardians	735	3,136	.518	1,623	1,513	107,055	14,551	27,637	5,851	487	3,352	13,879	10,450	1,230	23,109	1,840	665	120,295	44,518	9,690	657	903	596	2,369	.258	.329	.416	.744
7	Athletics	642	3,137	.515	1,615	1,522	106,778	14,096	26,611	5,555	460	3,316	13,410	10,687	1,074	22,705	1,473	490	119,806	43,034	9,331	408	859	457	2,470	.249	.321	.403	.724
8	Astros	544	3,138	.511	1,602	1,535	106,562	14,107	27,279	5,512	485	3,512	13,449	9,905	1,128	22,883	1,813	718	119,333	44,297	9,509	918	820	602	2,459	.256	.324	.416	.739
9	Blue Jays	475	3,137	.501	1,573	1,564	107,242	14,812	27,647	5,833	433	3,862	14,162	10,093	1,082	22,617	1,418	553	119,713	45,932	10,128	449	847	440	2,534	.258	.326	.428	.754
10	Angels	472	3,138	.523	1,642	1,496	107,045	14,408	27,861	5,309	516	3,306	13,698	9,447	1,048	21,560	2,125	812	119,053	44,120	9,131	651	862	719	2,473	.260	.324	.412	.736
11	Cubs	297	3,137	.505	1,583	1,553	106,737	13,935	27,130	5,548	562	3,485	13,255	9,995	1,244	24,609	1,455	667	119,707	44,257	9,595	1,003	728	740	2,383	.254	.323	.415	.738
12	Rays	231	3,138	.508	1,594	1,544	106,527	14,052	26,948	5,427	650	3,403	13,386	10,325	1,226	24,706	2,311	854	119,459	43,884	9,480	497	884	537	2,140	.253	.324	.412	.736
13	Phillies	215	3,138	.511	1,603	1,535	107,257	14,376	27,234	5,407	624	3,508	13,709	10,510	1,209	24,029	1,882	504	120,697	44,413	9,539	964	757	919	2,172	.254	.325	.414	.739
14	Giants	167	3,136	.514	1,611	1,525	106,791	13,409	27,255	5,480	679	2,825	12,725	9,700	976	22,190	1,432	608	119,393	42,568	8,984	1,069	857	958	2,483	.255	.321	.399	.719
15	Mets	68	3,137	.498	1,561	1,576	106,456	13,678	26,923	5,387	549	3,222	13,061	10,150	1,204	23,129	1,904	631	119,663	43,074	9,158	1,057	796	870	2,332	.253	.323	.405	.727
16	Twins	-96	3,140	.499	1,567	1,573	107,707	14,468	28,028	5,569	591	3,211	13,730	10,040	1,008	22,521	1,595	638	120,217	44,412	9,371	585	877	618	2,465	.260	.327	.412	.739
17	Brewers	-161	3,138	.503	1,578	1,560	106,117	13,968	26,731	5,418	534	3,692	13,350	10,212	1,345	25,363	2,047	691	119,420	44,293	9,644	992	754	754	2,373	.252	.323	.417	.741
18	Rangers	-216	3,139	.495	1,553	1,586	107,670	15,122	28,013	5,520	537	3,833	14,397	9,529	1,154	23,639	1,984	704	119,810	46,106	9,890	588	869	531	2,230	.260	.325	.428	.753
19	White Sox	-296	3,138	.494	1,550	1,588	106,937	14,071	27,557	5,134	445	3,641	13,489	9,008	1,258	23,159	1,695	787	118,651	44,504	9,220	667	781	443	2,455	.258	.321	.416	.737
20	Nationals	-317	3,136	.484	1,518	1,618	106,075	13,656	27,049	5,446	510	3,183	13,009	10,250	1,131	23,451	1,795	678	119,426	43,064	9,139	1,159	811	814	2,412	.255	.325	.406	.731
21	Diamondbacks	-777	3,138	.470	1,474	1,664	107,034	13,871	26,983	5,699	764	3,241	13,228	10,228	981	24,416	1,710	630	120,025	43,933	9,704	947	835	804	2,248	.252	.321	.410	.731
22	Rockies	-822	3,139	.465	1,461	1,678	107,599	15,107	28,641	5,756	791	3,485	14,412	10,025	946	24,487	1,669	710	120,618	46,434	10,032	1,255	793	767	2,338	.266	.332	.432	.763
23	Padres	-864	3,139	.475	1,492	1,647	105,804	12,937	26,014	5,073	593	2,946	12,298	10,143	997	24,638	1,856	671	118,775	41,111	8,612	1,012	819	688	2,215	.246	.315	.389	.704
24	Tigers	-882	3,134	.471	1,477	1,657	107,695	14,120	28,327	5,408	724	3,284	13,512	9,200	947	23,573	1,353	628	119,290	45,035	9,416	604	844	577	2,479	.263	.324	.418	.742
25	Mariners	-885	3,138	.479	1,502	1,636	107,012	13,249	26,874	5,041	455	3,189	12,602	9,287	1,069	23,286	1,807	696	118,717	42,392	8,685	594	755	583	2,279	.251	.315	.396	.711