Between the 2020 and 2023 seasons, the Los Angeles Dodgers had the highest run differential by a team, with a differential of 946 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Dodgers	946	546	.659	360	186	18,537	2,932	4,694	973	81	816	2,815	2,092	275	4,612	297	68	21,126	8,277	1,870	43	179	94	325	.253	.335	.447	.781
2	Braves	605	545	.602	328	217	18,543	2,874	4,800	990	57	892	2,769	1,796	223	4,813	301	81	20,727	8,580	1,939	36	129	82	351	.259	.330	.463	.792
3	Astros	557	546	.586	320	226	18,561	2,706	4,756	966	61	726	2,616	1,839	219	4,082	265	81	20,806	8,022	1,753	38	149	65	417	.256	.328	.432	.760
4	Rays	513	546	.595	325	221	18,405	2,672	4,532	971	89	671	2,545	1,842	252	4,965	391	129	20,642	7,694	1,731	19	124	56	315	.246	.321	.418	.739
5	Blue Jays	344	546	.557	304	242	18,616	2,669	4,858	988	48	738	2,565	1,749	187	4,271	280	95	20,696	8,156	1,774	30	114	45	416	.261	.329	.438	.767
6	Yankees	302	546	.560	306	240	17,991	2,506	4,254	746	42	789	2,381	2,049	210	4,780	292	88	20,406	7,451	1,577	34	122	73	445	.236	.320	.414	.734
7	Padres	254	546	.526	287	259	18,225	2,511	4,445	924	65	633	2,408	2,017	211	4,441	351	106	20,690	7,398	1,622	87	150	88	387	.244	.324	.406	.730
8	Brewers	216	546	.553	302	244	18,085	2,438	4,241	846	56	653	2,337	1,975	261	4,923	322	90	20,485	7,158	1,555	43	121	74	416	.235	.317	.396	.713
9	Giants	186	546	.542	296	250	18,285	2,493	4,424	889	70	679	2,392	1,912	267	4,914	206	54	20,662	7,490	1,638	63	135	86	393	.242	.321	.410	.730
10	Phillies	127	546	.526	287	259	18,351	2,583	4,598	898	92	705	2,479	1,810	216	4,726	358	81	20,590	7,795	1,695	74	139	90	369	.251	.323	.425	.748
11	Mets	100	546	.511	279	267	18,085	2,411	4,492	827	73	648	2,309	1,727	358	4,438	254	73	20,362	7,409	1,548	74	118	69	403	.248	.324	.410	.734
12	Twins	80	546	.502	274	272	18,333	2,472	4,471	885	62	730	2,361	1,823	253	4,940	192	57	20,574	7,670	1,677	31	134	50	412	.244	.319	.418	.737
13	Cardinals	70	544	.522	284	260	18,109	2,437	4,475	888	62	655	2,345	1,790	269	4,370	304	86	20,372	7,452	1,605	62	142	63	371	.247	.322	.412	.733
14	Mariners	66	546	.540	295	251	18,159	2,399	4,213	832	47	666	2,308	1,886	302	5,037	315	97	20,502	7,137	1,545	25	130	44	342	.232	.313	.393	.706
15	Guardians	58	546	.518	283	263	18,362	2,325	4,504	911	87	513	2,204	1,613	224	4,168	404	90	20,409	7,128	1,511	62	148	98	368	.245	.312	.388	.700
16	White Sox	-11	546	.495	270	276	18,516	2,429	4,650	905	50	606	2,322	1,530	227	4,653	221	60	20,446	7,473	1,561	57	116	39	432	.251	.314	.404	.718
17	Red Sox	-35	546	.498	272	274	18,679	2,628	4,850	1,139	61	637	2,499	1,663	216	4,676	235	76	20,731	8,022	1,837	37	136	68	400	.260	.325	.429	.755
18	Cubs	-87	546	.480	262	284	18,153	2,446	4,369	841	95	639	2,326	1,808	305	5,003	361	118	20,472	7,317	1,575	75	131	53	400	.241	.318	.403	.721
19	Rangers	-149	546	.440	240	306	18,414	2,437	4,452	855	71	660	2,317	1,655	182	4,791	362	103	20,423	7,429	1,586	38	134	42	331	.242	.309	.403	.712
20	Reds	-179	546	.473	258	288	18,144	2,460	4,377	874	71	666	2,358	1,800	322	4,889	313	114	20,446	7,391	1,611	66	114	40	401	.241	.319	.407	.726
21	Orioles	-202	546	.478	261	285	18,370	2,414	4,499	952	75	626	2,315	1,603	220	4,728	282	92	20,386	7,479	1,653	62	131	41	346	.245	.311	.407	.718
22	Angels	-243	546	.456	249	297	18,369	2,379	4,443	829	88	696	2,284	1,670	217	4,947	249	92	20,439	7,536	1,613	69	114	98	368	.242	.311	.410	.721
23	Marlins	-266	546	.460	251	295	18,175	2,138	4,380	814	71	528	2,028	1,507	210	4,806	365	93	20,067	6,920	1,413	62	113	60	411	.241	.305	.381	.686
24	Diamondbacks	-293	546	.430	235	311	18,273	2,396	4,370	945	111	541	2,263	1,789	208	4,514	335	78	20,521	7,160	1,597	100	151	54	354	.239	.312	.392	.704
25	Tigers	-363	544	.449	244	300	18,125	2,164	4,294	794	105	516	2,082	1,525	170	4,967	239	78	20,000	6,846	1,415	41	139	27	370	.237	.300	.378	.678