The Cleveland Indians had the highest run differential by a team in 1995, with a differential of 233 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Indians	233	1995	144	.694	100	44	5,028	840	1,461	279	23	207	803	542	35	766	132	53	5,684	2,407	509	31	48	40	128	.291	.361	.479	.839
2	Reds	124	1995	144	.590	85	59	4,903	747	1,326	277	35	161	694	519	40	946	190	68	5,574	2,156	473	62	50	42	92	.270	.342	.440	.782
3	Braves	105	1995	144	.625	90	54	4,814	645	1,202	210	27	168	618	520	40	933	73	43	5,464	1,970	405	56	34	37	106	.250	.326	.409	.735
4	Angels	104	1995	145	.538	78	67	5,019	801	1,390	252	25	186	761	564	36	889	58	39	5,690	2,250	463	33	38	40	115	.277	.352	.448	.800
5	Red Sox	93	1995	144	.597	86	58	4,997	791	1,399	286	31	175	754	560	65	923	99	44	5,716	2,272	492	45	49	38	129	.280	.357	.455	.812
6	Mariners	88	1995	145	.545	79	66	4,996	796	1,377	276	20	182	767	549	39	871	110	41	5,670	2,239	478	52	34	53	109	.276	.350	.448	.798
7	Astros	73	1995	144	.528	76	68	5,097	747	1,403	260	22	109	694	566	69	992	176	60	5,857	2,034	391	78	47	58	114	.275	.353	.399	.752
8	Orioles	64	1995	144	.493	71	73	4,837	704	1,267	229	27	173	668	574	39	803	92	45	5,531	2,069	429	40	41	36	119	.262	.342	.428	.770
9	Yankees	61	1995	145	.549	79	65	4,947	749	1,365	280	34	122	709	625	39	851	50	30	5,699	2,079	436	20	68	36	139	.276	.357	.420	.778
10	Mets	39	1995	144	.479	69	75	4,958	657	1,323	218	34	125	617	446	42	994	58	39	5,581	1,984	377	92	43	44	105	.267	.330	.400	.730
11	Dodgers	25	1995	144	.542	78	66	4,942	634	1,303	191	31	140	593	468	30	1,023	127	45	5,543	1,976	362	68	35	46	99	.264	.329	.400	.729
12	Cubs	22	1995	144	.507	73	71	4,963	693	1,315	267	39	158	648	440	34	953	105	37	5,543	2,134	464	71	35	46	110	.265	.327	.430	.757
13	Rockies	2	1995	144	.535	77	67	4,994	785	1,406	259	43	200	749	484	56	943	125	59	5,647	2,351	502	82	31	47	118	.282	.350	.471	.820
14	Marlins	0	1995	143	.469	67	76	4,886	673	1,278	214	29	144	636	517	49	916	131	53	5,569	1,982	387	69	48	36	105	.262	.335	.406	.741
15	White Sox	-3	1995	145	.472	68	76	5,060	755	1,417	252	37	146	712	576	32	767	110	39	5,770	2,181	435	46	56	54	106	.280	.354	.431	.785
16	Padres	-4	1995	144	.486	70	74	4,950	668	1,345	231	20	116	618	447	35	872	124	46	5,526	1,964	367	56	38	45	125	.272	.334	.397	.731
17	Brewers	-7	1995	144	.451	65	79	5,000	740	1,329	249	42	128	700	502	46	800	105	40	5,631	2,046	419	41	42	20	105	.266	.336	.409	.745
18	Expos	-17	1995	144	.458	66	78	4,905	621	1,268	265	24	118	572	400	56	901	120	49	5,451	1,935	407	58	32	43	107	.259	.320	.394	.714
19	Rangers	-29	1995	144	.514	74	70	4,913	691	1,304	247	24	138	651	526	33	877	90	47	5,566	2,013	409	49	45	28	112	.265	.338	.410	.747
20	Athletics	-31	1995	144	.465	67	77	4,916	730	1,296	228	18	169	694	565	45	911	112	46	5,616	2,067	415	32	58	25	108	.264	.341	.420	.762
21	Phillies	-43	1995	144	.479	69	75	4,950	615	1,296	263	30	94	576	497	46	884	72	25	5,611	1,901	387	77	41	38	107	.262	.332	.384	.716
22	Royals	-62	1995	144	.486	70	74	4,903	629	1,275	240	35	119	578	475	43	849	120	53	5,526	1,942	394	66	39	33	105	.260	.328	.396	.724
23	Cardinals	-95	1995	143	.434	62	81	4,779	563	1,182	238	24	107	533	436	46	920	79	46	5,349	1,789	369	48	40	31	110	.247	.314	.374	.688
24	Pirates	-107	1995	144	.403	58	86	4,937	629	1,281	245	27	125	587	456	24	972	84	55	5,501	1,955	397	51	33	45	88	.259	.323	.396	.719
25	Giants	-124	1995	144	.465	67	77	4,971	652	1,256	229	33	152	610	472	57	1,060	138	46	5,603	2,007	414	79	24	55	92	.253	.323	.404	.727