mlb highest run differential by team in season 2001 to 2021

Between the 2001 and 2021 seasons, the Seattle Mariners had the highest run differential by a team in a season, with a differential of 300 runs in 2001.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mariners	300	2001	162	.716	116	46	5,680	927	1,637	310	38	169	881	614	62	989	174	42	6,474	2,530	517	48	70	54	112	.288	.360	.445	.805
2	Astros	280	2019	162	.660	107	55	5,613	920	1,538	323	28	288	891	645	66	1,166	67	27	6,391	2,781	639	10	57	17	146	.274	.352	.495	.848
3	Dodgers	273	2019	162	.654	106	56	5,493	886	1,414	302	20	279	861	607	81	1,356	57	10	6,281	2,593	601	55	45	47	100	.257	.338	.472	.810
4	Dodgers	269	2021	162	.654	106	56	5,445	830	1,330	247	24	237	799	613	104	1,408	65	17	6,239	2,336	508	32	45	36	96	.244	.330	.429	.759
5	Astros	263	2018	162	.636	103	59	5,453	797	1,390	278	18	205	763	565	61	1,197	71	26	6,138	2,319	501	14	45	19	156	.255	.329	.425	.754
6	Indians	254	2017	162	.630	102	60	5,511	818	1,449	333	29	212	780	604	50	1,153	88	23	6,233	2,476	574	23	45	30	125	.263	.339	.449	.788
7	Cubs	252	2016	162	.640	103	58	5,503	808	1,409	293	30	199	767	656	96	1,339	66	34	6,334	2,359	522	42	37	45	107	.256	.343	.429	.772
8	Athletics	239	2001	162	.630	102	60	5,573	884	1,469	334	22	199	835	640	88	1,021	68	29	6,385	2,444	555	25	59	57	131	.264	.345	.439	.784
9	Red Sox	229	2018	162	.667	108	54	5,623	876	1,509	355	31	208	829	569	55	1,253	125	31	6,302	2,550	594	7	48	38	130	.268	.339	.453	.792
10	Blue Jays	221	2015	162	.574	93	69	5,509	891	1,480	308	17	232	852	570	54	1,151	88	23	6,231	2,518	557	36	62	12	140	.269	.340	.457	.797
11	Giants	210	2021	162	.660	107	55	5,462	804	1,360	271	25	241	768	602	64	1,461	66	14	6,194	2,404	537	36	30	45	117	.249	.329	.440	.769
12	Yankees	210	2011	162	.599	97	65	5,518	867	1,452	267	33	222	836	627	74	1,138	147	46	6,306	2,451	522	36	51	34	146	.263	.343	.444	.788
13	Red Sox	210	2007	162	.593	96	66	5,589	867	1,561	352	35	166	829	689	64	1,042	96	24	6,426	2,481	553	30	54	54	146	.279	.362	.444	.806
14	Angels	207	2002	162	.611	99	63	5,678	851	1,603	333	32	152	811	462	74	805	117	51	6,327	2,456	517	49	64	42	105	.282	.341	.433	.773
15	Rays	206	2021	162	.617	100	62	5,507	857	1,336	288	36	222	810	585	72	1,542	88	42	6,211	2,362	546	6	41	27	75	.243	.321	.429	.750
16	Astros	205	2021	162	.586	95	67	5,593	863	1,496	299	14	221	834	569	64	1,222	53	16	6,289	2,486	534	9	54	25	136	.267	.339	.444	.783
17	Yankees	204	2019	162	.636	103	59	5,583	943	1,493	290	17	306	904	569	49	1,437	55	22	6,244	2,735	613	10	33	18	113	.267	.339	.490	.829
18	Yankees	200	2002	161	.640	103	58	5,601	897	1,540	314	12	223	857	640	72	1,171	100	38	6,377	2,547	549	23	41	48	150	.275	.354	.455	.809
19	Yankees	198	2017	162	.562	91	71	5,594	858	1,463	266	23	241	821	616	64	1,386	90	22	6,348	2,498	530	18	56	22	119	.262	.339	.447	.785
20	Red Sox	197	2013	162	.599	97	65	5,651	853	1,566	363	29	178	819	581	72	1,308	123	19	6,378	2,521	570	24	50	51	137	.277	.349	.446	.795
21	Astros	196	2017	162	.623	101	61	5,611	896	1,581	346	20	238	854	509	70	1,087	98	42	6,262	2,681	604	11	61	27	139	.282	.346	.478	.823
22	Cardinals	196	2004	162	.648	105	57	5,555	855	1,544	319	24	214	817	548	51	1,085	111	47	6,297	2,553	557	73	70	64	121	.278	.344	.460	.804
23	Dodgers	194	2018	163	.564	92	71	5,572	804	1,394	296	33	235	756	647	61	1,436	75	24	6,358	2,461	564	39	39	47	119	.250	.333	.442	.774
24	Red Sox	194	2002	162	.574	93	69	5,640	859	1,560	348	33	177	810	545	72	944	80	28	6,332	2,505	558	22	53	39	139	.277	.345	.444	.789
25	Yankees	191	2007	162	.580	94	68	5,717	968	1,656	326	32	201	929	637	78	991	123	40	6,527	2,649	559	41	54	32	138	.290	.366	.463	.829