Since 1900, the New York Yankees have the highest run differential by a team, with a differential of 13,149 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,149	19,092	.570	10,823	8,181	650,692	92,763	172,731	28,686	5,499	17,360	86,198	68,705	4,936	95,113	11,671	2,810	737,224	264,495	51,545	9,597	3,294	2,843	10,706	.265	.339	.406	.745
2	Giants	6,057	19,541	.533	10,371	9,077	664,777	87,426	173,974	28,426	5,653	15,000	80,457	61,998	5,112	96,838	12,571	3,150	746,229	258,706	49,079	11,317	3,025	4,020	10,207	.262	.328	.389	.717
3	Dodgers	5,673	19,544	.532	10,348	9,101	664,465	85,211	173,273	28,249	5,726	13,715	78,540	62,363	4,451	97,649	13,413	3,554	746,584	254,119	47,690	12,232	3,073	3,743	9,967	.261	.327	.382	.709
4	Cardinals	3,846	19,553	.522	10,148	9,299	668,271	87,012	177,604	30,651	6,412	12,616	80,008	60,784	4,811	95,807	13,499	3,619	748,410	258,927	49,679	11,395	3,149	3,779	10,155	.266	.330	.387	.717
5	Red Sox	3,588	19,381	.518	9,995	9,303	663,321	90,509	176,975	33,178	5,603	14,641	83,937	66,914	4,821	95,868	9,651	2,556	749,000	265,282	53,422	10,599	3,345	3,003	11,568	.267	.337	.400	.737
6	Guardians	2,240	19,388	.513	9,891	9,406	660,771	87,619	174,888	31,192	5,501	13,942	80,980	62,706	4,844	94,853	11,936	3,393	743,148	258,908	50,635	11,466	3,361	2,550	10,547	.265	.331	.392	.723
7	Cubs	1,037	19,565	.505	9,818	9,640	665,224	85,336	172,728	29,678	5,722	14,332	78,413	60,993	4,750	102,088	11,988	3,076	746,298	256,846	49,732	12,415	2,916	3,524	9,977	.260	.325	.386	.711
8	Pirates	931	19,540	.504	9,804	9,640	667,397	84,917	175,954	29,528	7,433	11,849	78,057	58,319	4,796	96,839	12,673	3,280	745,440	255,895	48,810	11,804	3,124	3,702	10,079	.264	.326	.383	.709
9	Astros	752	10,057	.503	5,054	4,998	341,306	42,899	87,021	15,952	2,174	8,465	40,375	32,434	2,915	63,162	7,170	3,142	383,409	132,716	26,591	4,031	2,723	3,146	7,438	.255	.323	.389	.711
10	Blue Jays	376	7,629	.499	3,802	3,824	261,370	35,269	67,978	13,582	1,494	8,295	33,455	24,236	2,436	49,145	4,582	1,966	291,683	109,433	23,371	1,507	2,134	1,406	5,953	.260	.326	.419	.745
11	Tigers	338	19,415	.503	9,725	9,597	662,067	89,161	174,901	29,646	6,303	14,616	82,112	65,643	4,460	96,993	11,300	2,939	746,298	261,001	50,565	11,009	3,119	2,450	10,731	.264	.333	.394	.727
12	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
13	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
14	Rebels	-25	310	.495	150	153	10,154	1,197	2,657	360	170	54	1,027	858	77	1,085	377		11,485	3,519	584	396				.262	.324	.347	.670
15	Terriers	-26	313	.489	149	156	10,223	1,199	2,598	392	146	49	1,026	1,079	70	1,150	308		11,783	3,429	587	411				.254	.329	.335	.665
16	Tip-Tops	-41	310	.480	147	159	10,256	1,309	2,750	430	160	78	1,134	877	92	1,223	469		11,516	3,734	668	291				.268	.331	.364	.695
17	Blues	-42	308	.508	154	149	10,129	1,194	2,525	370	142	77	1,014	850	42	1,329	412		11,287	3,410	589	266				.249	.310	.337	.647
18	Packers	-43	307	.487	148	156	10,064	1,191	2,575	426	143	67	1,040	767	82	1,091	315		11,264	3,488	636	351				.256	.314	.347	.660
19	Orioles	-122	276	.435	118	153	9,349	1,476	2,666	381	218	57	1,231	786	106	797	396		10,459	3,654	656	218				.285	.347	.391	.738
20	White Sox	-178	19,388	.499	9,619	9,666	656,440	84,183	170,404	28,262	5,556	12,309	77,383	62,202	5,253	92,365	13,642	3,491	739,499	246,705	46,127	12,374	3,230	2,464	10,538	.260	.327	.376	.703
21	Terrapins	-193	314	.425	131	177	10,180	1,195	2,609	418	120	68	1,016	957	83	1,184	280		11,579	3,471	606	359				.256	.325	.341	.666
22	Diamondbacks	-278	4,350	.489	2,127	2,223	148,423	19,911	37,823	7,760	1,074	4,658	18,978	14,463	1,437	32,860	2,521	908	166,869	61,705	13,492	1,330	1,216	1,093	3,101	.255	.325	.416	.740
23	Rays	-404	4,348	.491	2,134	2,214	147,824	19,357	37,531	7,479	853	4,536	18,413	14,063	1,691	33,667	3,253	1,236	165,483	60,324	12,868	744	1,161	688	3,044	.254	.323	.408	.732
24	Reds	-643	19,561	.498	9,697	9,769	664,301	84,391	172,607	29,446	6,020	13,782	77,897	60,192	4,847	99,824	13,985	3,414	744,405	255,439	49,248	12,016	3,049	3,649	9,740	.260	.324	.385	.709
25	Angels	-708	10,217	.495	5,059	5,155	346,638	44,214	88,662	15,324	1,813	9,263	41,607	32,405	2,846	63,043	6,062	3,108	388,208	135,401	26,400	3,541	2,778	2,488	7,891	.256	.322	.391	.713