Adam Dunn had the most games with 2+ strikeouts, with 686 games.

Interpreted as:

MLB most regular-season games by a player with 2 or more strikeouts

	NAME	G	SO	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Adam Dunn A. Dunn	686	1,565	2,644	261	394	85	5	109	294	297	20	17	4	2,969	816	199	0	8	27	24	.149	.239	.309	.548
2	Jim Thome J. Thome	653	1,473	2,544	313	457	94	6	122	345	320	16	1	4	2,891	929	222	0	11	42	22	.180	.274	.365	.639
3	Reggie Jackson R. Jackson	653	1,471	2,602	256	430	69	10	85	255	222	19	42	19	2,856	774	164	3	10	27	31	.165	.235	.297	.533
4	Sammy Sosa S. Sosa	600	1,359	2,469	252	395	66	7	103	292	157	13	36	13	2,659	784	176	3	17	28	40	.160	.213	.318	.530
5	Giancarlo Stanton G. Stanton	597	1,396	2,403	234	385	80	2	97	260	173	11	8	3	2,596	760	179	0	9	23	36	.160	.219	.316	.535
6	Chris Davis C. Davis	554	1,297	2,135	182	296	53	1	75	206	167	18	5	4	2,330	576	129	0	10	14	15	.139	.206	.270	.476
7	Mark Reynolds M. Reynolds	551	1,263	2,086	213	299	49	8	68	201	191	12	23	6	2,308	568	125	2	17	4	22	.143	.218	.272	.490
8	Justin Upton J. Upton	538	1,220	2,105	219	335	61	8	66	210	191	12	28	6	2,321	610	135	1	12	11	32	.159	.232	.290	.522
9	Alex Rodriguez A. Rodriguez	529	1,157	2,171	268	387	70	2	95	291	170	22	49	12	2,382	746	167	2	17	13	39	.178	.243	.344	.587
10	Ryan Howard R. Howard	523	1,212	2,116	202	356	79	6	88	307	172	15	3	1	2,322	711	173	0	19	38	26	.168	.234	.336	.570
11	Paul Goldschmidt P. Goldschmidt	522	1,160	2,121	208	382	87	6	61	221	174	8	35	7	2,313	664	154	0	10	20	31	.180	.244	.313	.557
12	Jose Canseco J. Canseco	516	1,177	2,103	220	327	65	2	77	252	164	15	28	10	2,294	627	144	0	12	17	25	.155	.221	.298	.519
13	Mike Cameron M. Cameron	495	1,120	1,993	208	321	68	8	56	182	142	22	51	14	2,173	573	132	5	11	4	17	.161	.224	.288	.511
14	Andres Galarraga A. Galarraga	490	1,116	2,006	179	355	68	3	59	195	95	30	25	13	2,138	606	130	0	7	12	29	.177	.225	.302	.527
15	Eugenio Suárez E. Suárez	485	1,125	1,902	182	276	39	4	74	205	139	24	4	3	2,077	545	117	0	12	5	22	.145	.211	.287	.498
16	Dave Kingman D. Kingman	484	1,085	1,909	149	271	54	5	71	209	112	12	15	14	2,056	548	130	8	15	14	25	.142	.193	.287	.480
17	Curtis Granderson C. Granderson	482	1,075	1,980	250	328	69	19	74	179	181	17	30	12	2,190	657	162	4	8	6	10	.166	.241	.332	.572
18	Nelson Cruz N. Cruz	480	1,077	1,906	192	324	58	1	83	224	122	13	7	2	2,053	633	142	0	12	15	26	.170	.224	.332	.556
19	J.D. Martinez	475	1,076	1,917	171	345	71	5	70	225	120	13	7	1	2,064	636	146	0	14	9	35	.180	.232	.332	.563
20	Willie Stargell W. Stargell	465	1,026	1,863	183	320	56	6	77	226	141	13	5	3	2,031	619	139	2	12	33	20	.172	.234	.332	.566
21	Alfonso Soriano A. Soriano	460	1,014	1,950	209	351	80	5	72	207	82	15	48	15	2,062	657	157	3	12	13	18	.180	.218	.337	.555
22	B.J. Upton	451	1,021	1,807	171	298	49	5	42	134	140	5	74	21	1,964	483	96	5	7	3	20	.165	.226	.267	.493
23	Mike Schmidt M. Schmidt	451	996	1,751	176	268	45	7	57	184	198	9	24	8	1,976	498	109	6	12	29	19	.153	.241	.284	.526
24	Kyle Schwarber K. Schwarber	449	1,032	1,784	195	259	46	3	77	200	194	10	9	5	1,998	542	126	0	10	13	12	.145	.232	.304	.536
25	Bryce Harper B. Harper	449	1,011	1,798	182	288	54	4	59	174	190	4	25	11	2,001	527	117	2	7	30	20	.160	.241	.293	.534