Between the 2000 and 2009 seasons, Mariano Rivera had the most saves, with 397 saves.

Interpreted as:

MLB most regular-season saves in the 2000s by pitcher

	NAME	SV	G	W	L	W%	GS	ERA	SO	CG	SHO	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Mariano Rivera M. Rivera	397	651	45	39	.536	0	2.08	669	0	0	713.1	548	165	182	38	137	30	590	18	2,811	7	8.44	1.73	4.88	0.48	23.8	4.9	0.96	.263	2.30	46	2.60	58	6.91	148.3
2	Trevor Hoffman T. Hoffman	363	546	23	40	.365	0	2.77	523	0	0	533.0	432	164	180	46	124	5	466	20	2,142	17	8.83	2.09	4.22	0.78	24.4	5.8	1.04	.267	3.04	69	2.97	70	7.29	77.7
3	Jason Isringhausen J. Isringhausen	284	541	27	28	.491	0	3.03	510	0	0	556.1	439	187	211	41	234	19	447	27	2,342	24	8.25	3.79	2.18	0.66	21.8	10.0	1.21	.259	3.41	70	3.56	82	7.10	49.2
4	Billy Wagner B. Wagner	284	558	23	24	.489	0	2.40	698	0	0	580.2	405	155	176	55	170	23	465	18	2,309	33	10.82	2.63	4.11	0.85	30.2	7.4	0.99	.257	2.73	55	2.89	65	6.28	97
5	Francisco Cordero F. Cordero	250	590	31	35	.470	0	3.17	645	0	0	624.0	554	220	248	42	281	20	426	23	2,678	25	9.30	4.05	2.30	0.61	24.1	10.5	1.34	.303	3.58	68	3.34	73	7.99	83.7
6	Joe Nathan J. Nathan	246	514	39	18	.684	15	2.53	664	0	0	594.2	412	167	181	46	216	15	373	22	2,390	28	10.05	3.27	3.07	0.70	27.8	9.0	1.06	.253	2.74	58	3.03	70	6.24	84.9
7	Francisco Rodriguez F. Rodriguez	243	478	26	23	.531	0	2.53	660	0	0	519.2	356	146	164	41	236	9	363	25	2,133	44	11.43	4.09	2.80	0.71	30.9	11.1	1.14	.265	2.84	58	2.99	69	6.17	79.1
8	Armando Benitez A. Benitez	230	478	25	28	.472	0	3.12	535	0	0	487.1	356	169	188	64	233	5	378	19	2,026	11	9.88	4.30	2.30	1.18	26.4	11.5	1.21	.246	3.47	73	4.04	94	6.57	14.6
9	Troy Percival T. Percival	219	397	21	21	.500	1	3.37	370	0	0	385.0	281	144	157	51	168	14	322	13	1,599	17	8.65	3.93	2.20	1.19	23.1	10.5	1.17	.231	3.67	76	4.28	97	6.57	6.3
10	Brad Lidge B. Lidge	195	517	25	28	.472	1	3.56	714	0	0	529.0	432	209	228	51	239	32	322	29	2,259	41	12.15	4.07	2.99	0.87	31.6	10.6	1.27	.312	3.88	82	3.18	72	7.35	71.8
11	Bob Wickman B. Wickman	193	383	13	24	.351	0	3.08	303	0	0	370.2	364	127	147	27	121	11	317	14	1,589	8	7.36	2.94	2.50	0.66	19.1	7.6	1.31	.299	3.57	69	3.46	78	8.84	40.7
12	Todd Jones T. Jones	191	590	30	39	.435	1	4.30	449	0	0	605.1	660	289	316	56	212	21	348	26	2,640	19	6.68	3.15	2.12	0.83	17.0	8.0	1.44	.318	4.70	94	3.94	88	9.81	35.3
13	Eric Gagne E. Gagne	187	397	32	25	.561	43	3.53	688	0	0	613.2	500	241	260	73	211	33	269	13	2,545	17	10.09	3.09	3.26	1.07	27.0	8.3	1.16	.277	3.81	84	3.56	81	7.33	55.9
14	Jose Mesa J. Mesa	184	532	26	40	.394	0	4.38	394	0	0	532.2	555	259	280	58	238	23	359	25	2,363	27	6.66	4.02	1.66	0.98	16.7	10.1	1.49	.301	4.73	99	4.47	101	9.38	-3.8
15	Keith Foulke K. Foulke	178	471	31	27	.534	0	3.04	484	0	0	542.2	441	183	189	61	130	33	352	15	2,197	9	8.03	2.16	3.72	1.01	22.0	5.9	1.05	.255	3.13	66	3.63	81	7.31	53.2
16	Eddie Guardado E. Guardado	178	540	28	27	.509	0	3.52	442	0	0	508.1	437	199	212	74	160	8	327	19	2,097	13	7.83	2.83	2.76	1.31	21.1	7.6	1.17	.257	3.75	77	4.20	95	7.74	12.2
17	Jose Valverde J. Valverde	167	379	19	19	.500	0	3.17	470	0	0	386.0	296	136	148	44	155	14	297	18	1,613	16	10.96	3.61	3.03	1.03	29.1	9.6	1.17	.271	3.45	71	3.46	78	6.90	42.2
18	Brian Fuentes B. Fuentes	163	503	18	32	.360	0	3.47	526	0	0	477.0	396	184	196	47	203	45	303	19	2,034	25	9.92	3.83	2.59	0.89	25.9	10.0	1.26	.288	3.70	74	3.72	82	7.47	43.1
19	John Smoltz J. Smoltz	154	367	56	42	.571	125	3.28	986	6	2	1058.2	982	386	405	93	236	19	204	29	4,324	26	8.38	2.01	4.18	0.79	22.8	5.5	1.15	.297	3.44	76	3.09	71	8.35	147.5
20	Jonathan Papelbon J. Papelbon	151	268	14	11	.560	3	1.84	346	0	0	298.0	215	61	70	21	77	12	227	5	1,187	5	10.45	2.33	4.49	0.63	29.1	6.5	0.98	.265	2.11	40	2.62	61	6.49	56.8
21	Danny Graves D. Graves	147	351	31	36	.463	30	4.26	283	2	1	560.1	621	265	303	76	164	22	261	39	2,430	18	4.55	2.63	1.73	1.22	11.6	6.7	1.40	.289	4.87	98	4.78	106	9.97	-16.7
22	Bobby Jenks B. Jenks	146	274	13	15	.464	0	3.21	273	0	0	289.0	248	103	109	22	92	7	236	22	1,188	14	8.50	2.87	2.97	0.69	23.0	7.7	1.18	.285	3.39	69	3.26	71	7.72	42.2
23	Ugueth Urbina U. Urbina	135	345	15	25	.375	0	3.49	413	0	0	350.2	263	136	143	45	151	4	235	15	1,454	13	10.60	3.88	2.74	1.15	28.4	10.4	1.18	.259	3.67	78	3.66	83	6.75	28.9
24	Billy Koch B. Koch	132	323	29	20	.592	0	3.98	300	0	0	343.2	324	152	166	36	161	15	277	22	1,505	19	7.86	4.22	1.86	0.94	19.9	10.7	1.41	.290	4.35	87	4.19	92	8.48	14.5
25	Joe Borowski J. Borowski	131	366	17	27	.386	1	4.13	339	0	0	385.1	372	177	186	47	136	6	242	23	1,652	5	7.92	3.18	2.49	1.10	20.5	8.2	1.32	.289	4.34	96	4.00	92	8.69	14.1