Dean Chance has the most career strikeouts per at-bat when making 300+ plate appearances, with 0.63.
Interpreted as:
MLB most strikeouts per at bats by a player minimum 300 plate appearances| NAME | SO/AB | PA | SO | AB | G | R | H | 2B | 3B | HR | RBI | BB | HBP | SB | CS | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | wRC | WRAA | wOBA | wRC+ | BRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Chance | 0.63 | 759 | 420 | 662 | 403 | 17 | 44 | 2 | 0 | 0 | 16 | 30 | 5 | 0 | 0 | 46 | 2 | 61 | 1 | 0 | 2 | .066 | .113 | .069 | .183 | -40 | -119.7 | .093 | -47 | -124.2 |
| 2 | | B. Stoneman | 0.63 | 402 | 212 | 338 | 240 | 23 | 29 | 4 | 0 | 0 | 8 | 23 | 2 | 1 | 0 | 33 | 4 | 38 | 1 | 0 | 1 | .086 | .148 | .098 | .246 | -13 | -55.1 | .125 | -31 | -59.6 |
| 3 | | A. Wood | 0.62 | 323 | 171 | 276 | 193 | 8 | 23 | 2 | 0 | 0 | 12 | 14 | 0 | 1 | 1 | 25 | 2 | 33 | 0 | 0 | 3 | .083 | .128 | .091 | .218 | -17 | -54.5 | .106 | -41 | -55.2 |
| 4 | | G. Gentry | 0.61 | 324 | 174 | 285 | 158 | 10 | 27 | 4 | 0 | 0 | 12 | 11 | 1 | 0 | 1 | 31 | 4 | 25 | 2 | 0 | 1 | .095 | .130 | .109 | .239 | -13 | -47.4 | .116 | -35 | -50 |
| 5 | | H. Aguirre | 0.61 | 427 | 236 | 388 | 444 | 14 | 33 | 7 | 1 | 0 | 21 | 14 | 0 | 1 | 0 | 42 | 8 | 24 | 1 | 0 | 4 | .085 | .117 | .108 | .225 | -21 | -67.7 | .106 | -42 | -72.2 |
| 6 | | W. Wood | 0.59 | 381 | 189 | 322 | 458 | 11 | 27 | 2 | 0 | 0 | 13 | 20 | 1 | 1 | 0 | 29 | 2 | 38 | 0 | 0 | 7 | .084 | .140 | .090 | .230 | -14 | -52.5 | .117 | -36 | -55.7 |
| 7 |  | A. Nola | 0.58 | 318 | 158 | 271 | 152 | 15 | 24 | 6 | 0 | 0 | 12 | 21 | 1 | 0 | 0 | 30 | 6 | 24 | 1 | 0 | 4 | .089 | .156 | .111 | .267 | -11 | -49.2 | .131 | -28 | -51.1 |
| 8 | | S. Barber | 0.57 | 649 | 320 | 563 | 398 | 24 | 65 | 5 | 2 | 5 | 27 | 38 | 2 | 0 | 1 | 89 | 12 | 45 | 1 | 0 | 2 | .115 | .174 | .158 | .332 | -4 | -73.6 | .159 | -3 | -76.7 |
| 9 | | M. Garza | 0.57 | 314 | 155 | 274 | 152 | 7 | 22 | 3 | 0 | 0 | 4 | 6 | 3 | 0 | 1 | 25 | 3 | 31 | 0 | 0 | 2 | .080 | .110 | .091 | .201 | -20 | -55.7 | .095 | -56 | -57.8 |
| 10 | | L. Lynn | 0.56 | 333 | 159 | 283 | 176 | 15 | 24 | 5 | 0 | 0 | 7 | 12 | 2 | 0 | 0 | 29 | 5 | 35 | 1 | 0 | 2 | .085 | .128 | .102 | .230 | -17 | -54.6 | .110 | -41 | -55.2 |
| 11 | | D. Darwin | 0.56 | 334 | 171 | 305 | 288 | 15 | 39 | 11 | 2 | 2 | 22 | 6 | 1 | 2 | 0 | 60 | 15 | 20 | 2 | 0 | 1 | .128 | .146 | .197 | .343 | -6 | -46.2 | .152 | -14 | -45.6 |
| 12 | | R. Washburn | 0.56 | 420 | 201 | 361 | 239 | 22 | 38 | 6 | 2 | 1 | 24 | 20 | 1 | 0 | 0 | 51 | 9 | 35 | 3 | 0 | 6 | .105 | .153 | .141 | .295 | -7 | -51.2 | .141 | -18 | -55.8 |
| 13 | | M. Batista | 0.56 | 351 | 173 | 311 | 352 | 20 | 28 | 5 | 0 | 2 | 9 | 11 | 0 | 0 | 0 | 39 | 7 | 28 | 1 | 0 | 6 | .090 | .121 | .125 | .246 | -20 | -63.4 | .114 | -48 | -66.5 |
| 14 |  | B. Colon | 0.56 | 326 | 166 | 299 | 148 | 11 | 25 | 4 | 0 | 1 | 11 | 1 | 2 | 0 | 0 | 32 | 5 | 22 | 2 | 0 | 7 | .084 | .092 | .107 | .199 | -23 | -61 | .089 | -57 | -61.5 |
| 15 | | S. Williams | 0.55 | 560 | 275 | 502 | 477 | 28 | 59 | 6 | 1 | 5 | 31 | 27 | 2 | 0 | 0 | 82 | 12 | 29 | 0 | 1 | 4 | .118 | .166 | .163 | .329 | -6 | -67.5 | .155 | -10 | -73.1 |
| 16 | | A. Leiter | 0.55 | 613 | 290 | 530 | 271 | 15 | 45 | 7 | 1 | 0 | 16 | 35 | 0 | 0 | 0 | 54 | 8 | 48 | 0 | 0 | 10 | .085 | .142 | .102 | .243 | -33 | -110.2 | .121 | -38 | -110 |
| 17 | | J. Fassero | 0.55 | 340 | 151 | 276 | 553 | 21 | 23 | 2 | 1 | 0 | 6 | 18 | 0 | 1 | 0 | 27 | 3 | 45 | 1 | 0 | 0 | .083 | .139 | .098 | .237 | -18 | -60.4 | .119 | -43 | -61.5 |
| 18 | | D. Drago | 0.54 | 328 | 149 | 274 | 150 | 11 | 21 | 4 | 0 | 0 | 12 | 21 | 1 | 0 | 0 | 25 | 4 | 32 | 0 | 0 | 1 | .077 | .145 | .091 | .237 | -12 | -46.4 | .122 | -32 | -48.3 |
| 19 | | J. Johnson | 0.54 | 318 | 146 | 272 | 149 | 14 | 34 | 5 | 0 | 3 | 25 | 14 | 0 | 0 | 0 | 48 | 8 | 32 | 0 | 0 | 2 | .125 | .168 | .176 | .344 | -5 | -42.9 | .159 | -14 | -44.3 |
| 20 | | B. Veale | 0.53 | 676 | 337 | 630 | 349 | 26 | 72 | 7 | 1 | 0 | 18 | 18 | 0 | 0 | 0 | 81 | 8 | 28 | 0 | 0 | 8 | .114 | .139 | .129 | .267 | -20 | -90.5 | .125 | -26 | -95.6 |
| 21 | | C. Anderson | 0.53 | 312 | 146 | 275 | 174 | 6 | 25 | 2 | 0 | 0 | 10 | 4 | 2 | 0 | 0 | 27 | 2 | 31 | 0 | 0 | 3 | .091 | .110 | .098 | .209 | -20 | -56.6 | .096 | -55 | -59 |
| 22 | | J. Nash | 0.53 | 403 | 199 | 375 | 202 | 16 | 38 | 6 | 1 | 4 | 21 | 9 | 0 | 0 | 0 | 58 | 11 | 18 | 1 | 0 | 2 | .101 | .122 | .155 | .277 | -11 | -52.5 | .128 | -26 | -56 |
| 23 |  | C. Morton | 0.53 | 370 | 170 | 321 | 189 | 9 | 27 | 5 | 0 | 0 | 7 | 3 | 0 | 0 | 1 | 32 | 5 | 44 | 2 | 0 | 4 | .084 | .092 | .100 | .192 | -26 | -68.7 | .086 | -58 | -69.3 |
| 24 | | V. Blue | 0.53 | 618 | 271 | 512 | 270 | 37 | 53 | 9 | 0 | 4 | 15 | 49 | 3 | 0 | 2 | 74 | 13 | 53 | 1 | 0 | 2 | .104 | .186 | .145 | .330 | -3 | -70.5 | .165 | -1 | -69.7 |
| 25 | | E. Moseley | 0.53 | 314 | 148 | 280 | 142 | 17 | 32 | 2 | 2 | 0 | 12 | 17 | 0 | 6 | 38 | 4 | 17 | .114 | .165 | .136 | .301 | -3 | -35.4 | .154 | -9 | -38.7 | ||||
StatMuse has season-level data for strikeouts going back to the 1891 season.
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MLB 2025 Pitching Leaders
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MLB 2025 Standings
| NL East | W | L | PCT | GB |
|---|---|---|---|---|
 Phillies - y | 96 | 66 | .593 | |
83 | 79 | .512 | 13.0 | |
79 | 83 | .488 | 17.0 | |
76 | 86 | .469 | 20.0 | |
66 | 96 | .407 | 30.0 | |
| NL Central | W | L | PCT | GB |
 Brewers - y | 97 | 65 | .599 | |
 Cubs - w | 92 | 70 | .568 | 5.0 |
 Reds - w | 83 | 79 | .512 | 14.0 |
78 | 84 | .481 | 19.0 | |
71 | 91 | .438 | 26.0 | |
| NL West | W | L | PCT | GB |
 Dodgers - y | 93 | 69 | .574 | |
 Padres - w | 90 | 72 | .556 | 3.0 |
81 | 81 | .500 | 12.0 | |
80 | 82 | .494 | 13.0 | |
43 | 119 | .265 | 50.0 |
Mets
Marlins
Braves
Nationals
Cardinals
Pirates
Giants
Diamondbacks
Rockies| AL East | W | L | PCT | GB |
|---|---|---|---|---|
 Blue Jays - y | 94 | 68 | .580 | |
 Yankees - w | 94 | 68 | .580 | |
 Red Sox - w | 89 | 73 | .549 | 5.0 |
77 | 85 | .475 | 17.0 | |
75 | 87 | .463 | 19.0 | |
| AL Central | W | L | PCT | GB |
 Guardians - y | 88 | 74 | .543 | |
 Tigers - w | 87 | 75 | .537 | 1.0 |
82 | 80 | .506 | 6.0 | |
70 | 92 | .432 | 18.0 | |
60 | 102 | .370 | 28.0 | |
| AL West | W | L | PCT | GB |
 Mariners - y | 90 | 72 | .556 | |
87 | 75 | .537 | 3.0 | |
81 | 81 | .500 | 9.0 | |
76 | 86 | .469 | 14.0 | |
72 | 90 | .444 | 18.0 |
Rays
Orioles
Royals
Twins
White Sox
