Andrew McCutchen has the most career games by an active player, with 2,196 games.

Interpreted as:

MLB player most regular-season games by active player

	NAME	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Andrew McCutchen A. McCutchen	2,196	8,115	1,263	2,216	442	50	327	1,123	1,145	94	1,831	220	89	9,431	3,739	819	3	74	70	139	.273	.366	.461	.827	1415	319.8	.358	127	297
2	Carlos Santana C. Santana	2,151	7,650	1,092	1,848	399	17	332	1,118	1,311	43	1,500	62	18	9,069	3,277	748	0	65	66	187	.242	.353	.428	.781	1243	185.4	.340	115	160.6
3	Freddie Freeman F. Freeman	2,098	7,803	1,336	2,346	529	32	352	1,273	1,038	109	1,690	98	31	9,014	3,995	913	0	64	140	166	.301	.388	.512	.899	1546	494.6	.382	142	461.7
4	Paul Goldschmidt P. Goldschmidt	2,004	7,394	1,252	2,138	461	24	370	1,219	1,074	51	1,933	174	35	8,575	3,757	855	0	56	119	170	.289	.381	.508	.889	1441	437.5	.378	138	393.4
5	Jose Altuve J. Altuve	1,895	7,579	1,192	2,309	441	31	241	846	624	77	1,081	321	94	8,356	3,535	713	26	50	48	202	.305	.361	.466	.828	1256	282.9	.356	129	288
6	Manny Machado M. Machado	1,811	7,097	1,042	1,989	383	18	354	1,095	639	27	1,354	107	40	7,839	3,470	755	14	62	69	217	.280	.339	.489	.828	1151	231.3	.351	124	223.3
7	Nolan Arenado N. Arenado	1,752	6,681	980	1,894	398	34	351	1,171	572	43	1,077	29	23	7,379	3,413	783	5	78	80	198	.283	.340	.511	.851	1127	260.3	.358	117	155.7
8	Justin Turner J. Turner	1,719	5,638	804	1,600	349	9	199	825	585	136	995	46	13	6,426	2,564	557	5	62	18	145	.284	.361	.455	.816	955	199.5	.353	125	197.3
9	Bryce Harper B. Harper	1,710	6,147	1,114	1,725	382	24	345	1,010	1,070	49	1,580	148	50	7,338	3,190	751	13	59	133	136	.281	.388	.519	.907	1269	408	.383	141	370.1
10	DJ LeMahieu	1,660	6,098	892	1,762	278	39	126	661	572	31	1,036	93	49	6,785	2,496	443	37	47	24	188	.289	.350	.409	.760	885	88.3	.331	100	5.9
11	Giancarlo Stanton G. Stanton	1,655	6,044	907	1,557	306	11	429	1,104	778	53	1,969	42	15	6,914	3,172	746	0	39	88	154	.258	.345	.525	.870	1096	295.3	.368	135	289.3
12	Salvador Perez S. Perez	1,625	6,166	674	1,638	304	11	281	955	256	87	1,243	6	1	6,562	2,807	596	0	53	40	190	.266	.302	.455	.757	805	43.4	.323	102	13.8
13	Nick Castellanos N. Castellanos	1,617	6,155	790	1,687	391	42	241	888	417	53	1,543	40	22	6,675	2,885	674	0	50	19	137	.274	.323	.469	.792	911	123.1	.337	111	94.8
14	Xander Bogaerts X. Bogaerts	1,605	6,125	918	1,760	368	18	190	813	575	55	1,228	119	23	6,820	2,734	576	5	60	23	156	.287	.351	.446	.797	965	160.4	.344	115	123.7
15	Marcus Semien M. Semien	1,579	6,166	935	1,566	315	36	245	771	613	24	1,269	134	40	6,848	2,688	596	7	38	8	98	.254	.322	.436	.758	878	67.6	.327	108	71.1
16	Mike Trout M. Trout	1,568	5,690	1,146	1,690	313	55	390	982	1,006	102	1,541	214	38	6,856	3,283	758	0	58	124	71	.297	.408	.577	.985	1341	545.6	.413	168	547.9
17	Eugenio Suárez E. Suárez	1,548	5,515	788	1,371	249	15	301	898	607	97	1,700	33	19	6,288	2,553	565	9	60	15	124	.249	.330	.463	.793	874	127.3	.340	113	98.8
18	Marcell Ozuna M. Ozuna	1,542	5,819	795	1,580	271	21	286	920	563	25	1,418	29	14	6,441	2,751	578	1	33	20	148	.272	.337	.473	.809	926	169.3	.347	120	157.1
19	Christian Yelich C. Yelich	1,539	5,813	982	1,662	316	35	218	802	800	48	1,465	217	39	6,693	2,702	569	5	27	57	121	.286	.375	.465	.840	1045	258.3	.362	129	240.9
20	José Ramírez J. Ramírez	1,524	5,652	941	1,589	380	41	268	900	627	40	762	263	60	6,394	2,855	689	19	56	95	79	.281	.354	.505	.859	999	240.4	.361	131	232.9
21	Starling Marte S. Marte	1,482	5,592	859	1,595	283	55	158	651	332	165	1,225	358	100	6,134	2,462	496	22	23	18	117	.285	.342	.440	.783	837	120.3	.339	116	114.4
22	Mookie Betts M. Betts	1,452	5,769	1,120	1,685	380	40	280	868	710	50	887	194	39	6,586	2,985	700	4	53	35	76	.292	.371	.517	.889	1116	334.1	.377	138	305.6
23	Francisco Lindor F. Lindor	1,450	5,742	942	1,572	318	26	263	811	551	72	1,051	198	47	6,457	2,731	607	31	61	36	104	.274	.342	.476	.817	939	170.6	.348	121	160.5
24	George Springer G. Springer	1,377	5,290	913	1,384	237	23	271	744	643	79	1,266	109	40	6,048	2,480	531	2	34	12	116	.262	.348	.469	.817	897	181.6	.352	126	191.7
25	Joc Pederson J. Pederson	1,318	3,809	588	903	186	18	211	555	517	87	1,048	30	27	4,444	1,758	415	6	25	27	68	.237	.340	.462	.801	630	102.7	.344	118	98.6