Since 1998, the Kansas City Royals have lost the most games by a team, with 2,413 losses.

Interpreted as:

MLB team most regular-season losses since 1998

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Royals	2,413	1,890	.561	4,303	.439	147,383	18,913	38,562	7,463	958	3,756	17,923	11,701	1,487	28,689	3,029	1,068	162,812	59,209	12,177	973	1,268	649	3,371	.262	.320	.402	.721
2	Pirates	2,374	1,926	.552	4,302	.448	145,725	18,013	36,578	7,303	834	3,929	17,170	13,007	1,786	32,584	2,343	1,030	163,054	57,336	12,066	1,448	1,088	928	3,087	.251	.318	.393	.711
3	Rockies	2,342	1,964	.544	4,306	.456	147,842	21,014	39,671	7,952	1,083	4,786	20,013	13,605	1,308	32,772	2,349	1,030	165,548	64,147	13,821	1,646	1,147	1,012	3,255	.268	.333	.434	.767
4	Marlins	2,338	1,962	.544	4,300	.456	146,237	18,087	37,188	7,210	837	3,976	17,151	12,901	1,575	33,263	2,711	1,049	163,213	58,000	12,023	1,435	1,065	996	3,212	.254	.319	.397	.716
5	Orioles	2,326	1,975	.541	4,303	.459	147,700	19,534	38,220	7,494	543	5,013	18,664	12,678	1,502	30,419	2,253	885	163,768	61,839	13,050	750	1,138	657	3,344	.259	.321	.419	.740
6	Tigers	2,303	1,996	.536	4,299	.464	147,457	19,218	38,431	7,398	1,007	4,471	18,379	12,609	1,362	31,916	2,040	952	163,381	61,256	12,876	789	1,164	716	3,298	.261	.322	.415	.738
7	Nationals	2,278	2,025	.529	4,303	.471	145,430	18,657	37,102	7,566	738	4,284	17,727	13,634	1,540	31,307	2,615	1,050	163,304	58,996	12,588	1,619	1,081	1,098	3,287	.255	.323	.406	.729
8	Reds	2,254	2,052	.523	4,308	.477	146,140	19,378	36,941	7,340	663	4,909	18,504	14,280	1,777	33,645	2,781	1,048	164,796	60,334	12,912	1,538	1,061	1,006	3,064	.253	.325	.413	.737
9	White Sox	2,229	2,075	.518	4,306	.482	146,733	19,608	37,914	7,169	634	4,978	18,770	12,611	1,596	30,904	2,448	1,077	163,003	61,285	12,781	949	1,114	603	3,347	.258	.322	.418	.739
10	Padres	2,224	2,081	.517	4,305	.483	145,212	18,240	35,991	6,995	772	4,143	17,341	14,417	1,319	32,998	2,726	985	163,344	56,959	11,910	1,276	1,120	926	3,124	.248	.319	.392	.711
11	Diamondbacks	2,201	2,104	.511	4,305	.489	146,881	19,670	37,416	7,684	1,063	4,588	18,740	14,310	1,414	32,510	2,492	897	165,128	60,990	13,335	1,323	1,200	1,088	3,071	.255	.324	.415	.740
12	Rays	2,197	2,106	.511	4,303	.489	146,298	19,110	37,123	7,405	850	4,479	18,180	13,923	1,671	33,287	3,188	1,219	163,780	59,665	12,734	737	1,151	685	3,020	.254	.323	.408	.731
13	Brewers	2,180	2,124	.507	4,305	.493	145,667	19,261	36,723	7,371	718	4,903	18,395	14,315	1,774	34,369	2,827	993	164,170	60,239	12,992	1,376	1,038	1,001	3,250	.252	.324	.414	.738
14	Twins	2,174	2,131	.505	4,306	.495	147,705	19,823	38,478	7,773	827	4,321	18,792	13,734	1,471	30,837	2,311	974	164,855	60,868	12,921	732	1,213	811	3,414	.261	.327	.412	.739
15	Rangers	2,170	2,136	.504	4,306	.496	148,071	21,256	38,991	7,690	719	5,353	20,243	13,580	1,515	31,654	2,608	969	165,191	64,178	13,762	803	1,222	749	3,154	.263	.329	.433	.762
16	Cubs	2,158	2,146	.501	4,305	.499	146,459	19,517	37,248	7,437	783	4,878	18,586	14,209	1,643	33,482	2,130	919	164,816	60,885	13,098	1,456	1,049	1,036	3,185	.254	.325	.416	.741
17	Mariners	2,153	2,149	.500	4,302	.500	146,837	19,214	37,362	7,070	626	4,629	18,297	13,729	1,576	32,026	2,780	1,006	164,117	59,571	12,325	843	1,132	827	3,081	.254	.323	.406	.728
18	Blue Jays	2,139	2,165	.497	4,305	.503	147,452	20,485	38,207	8,033	607	5,288	19,575	13,918	1,593	30,863	2,231	847	164,749	63,318	13,928	623	1,163	657	3,420	.259	.327	.429	.757
19	Mets	2,121	2,183	.493	4,304	.507	145,959	19,020	37,026	7,327	691	4,504	18,144	14,301	1,679	31,275	2,578	916	164,473	59,247	12,522	1,434	1,100	1,153	3,230	.254	.325	.406	.731
20	Phillies	2,114	2,190	.491	4,304	.509	147,190	19,824	37,621	7,545	873	4,717	18,891	14,634	1,583	32,636	2,782	766	165,827	61,063	13,135	1,331	1,089	1,211	2,998	.256	.327	.415	.742
21	Angels	2,102	2,201	.488	4,303	.512	146,892	19,797	38,210	7,303	701	4,597	18,834	13,099	1,514	29,676	2,835	1,142	163,603	60,706	12,601	905	1,193	928	3,323	.260	.325	.413	.738
22	Athletics	2,095	2,209	.487	4,304	.513	146,378	19,799	36,621	7,547	611	4,755	18,847	15,184	1,549	31,394	2,086	700	164,902	59,655	12,913	625	1,166	660	3,386	.250	.325	.408	.732
23	Astros	2,057	2,245	.478	4,303	.522	146,448	20,033	37,953	7,611	675	4,910	19,096	14,196	1,634	31,187	2,604	1,035	164,732	61,644	13,196	1,278	1,176	927	3,437	.259	.329	.421	.750
24	Giants	2,056	2,248	.478	4,305	.522	146,596	19,155	37,622	7,564	890	4,219	18,226	14,185	1,386	30,576	1,999	863	164,860	59,623	12,673	1,476	1,217	1,329	3,357	.257	.326	.407	.732
25	Guardians	2,051	2,251	.477	4,302	.523	146,902	20,492	38,231	7,934	691	4,731	19,524	14,665	1,656	31,008	2,697	977	165,413	61,740	13,356	905	1,285	841	3,273	.260	.332	.420	.752