Since 2016, the Chicago White Sox have lost the most games by a team, with 867 losses.

Interpreted as:

MLB team most regular-season losses since 2016

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	White Sox	867	650	.572	1,517	.428	51,391	6,339	12,702	2,426	199	1,622	6,074	4,082	580	13,245	705	250	56,594	20,392	4,247	221	320	119	1,115	.247	.308	.397	.705
2	Rockies	863	655	.569	1,518	.431	51,678	6,996	13,216	2,688	345	1,726	6,712	4,409	465	13,558	702	284	57,248	21,772	4,759	325	371	223	1,127	.256	.318	.421	.739
3	Royals	851	667	.561	1,518	.439	51,221	6,342	12,763	2,497	300	1,518	6,058	3,983	529	11,830	1,131	350	56,373	20,414	4,315	228	412	143	1,046	.249	.308	.399	.706
4	Marlins	848	668	.559	1,516	.441	51,389	6,121	12,701	2,346	238	1,428	5,832	4,175	586	12,811	890	299	56,755	19,807	4,012	264	341	219	1,141	.247	.309	.385	.695
5	Pirates	847	669	.559	1,517	.441	50,961	6,206	12,327	2,436	283	1,401	5,919	4,722	577	12,727	814	317	56,888	19,532	4,120	272	356	243	1,040	.242	.311	.383	.695
6	Tigers	836	678	.552	1,514	.448	51,148	6,301	12,483	2,399	329	1,558	6,033	4,327	492	13,434	626	231	56,446	20,214	4,286	102	377	136	1,031	.244	.307	.395	.702
7	Angels	828	690	.545	1,518	.455	50,960	6,604	12,294	2,315	198	1,863	6,317	4,730	651	12,755	833	289	56,859	20,594	4,376	158	360	242	1,125	.241	.312	.404	.716
8	Orioles	826	692	.544	1,518	.456	51,630	6,715	12,741	2,493	185	1,938	6,431	4,320	581	13,127	717	232	57,027	21,418	4,616	134	362	128	1,019	.247	.310	.415	.725
9	Reds	822	696	.542	1,518	.458	50,870	6,741	12,465	2,393	246	1,789	6,435	4,891	738	13,188	1,041	350	57,137	20,717	4,428	283	355	200	1,077	.245	.318	.407	.726
10	Athletics	803	715	.529	1,518	.471	51,011	6,596	12,205	2,561	180	1,880	6,310	4,844	617	13,021	710	218	56,975	20,766	4,621	145	358	135	1,146	.239	.311	.407	.718
11	Rangers	801	717	.528	1,518	.472	51,277	6,915	12,483	2,394	193	1,880	6,590	4,700	606	13,177	1,010	314	57,094	20,903	4,467	150	361	156	945	.243	.312	.408	.720
12	Nationals	797	721	.525	1,518	.475	51,177	6,893	13,021	2,601	236	1,671	6,580	4,822	619	11,871	1,110	350	57,322	21,107	4,508	307	397	293	1,110	.254	.324	.412	.736
13	Diamondbacks	785	733	.517	1,518	.483	51,558	7,143	12,785	2,639	371	1,772	6,797	5,044	599	12,798	982	247	57,954	21,482	4,782	322	431	251	1,028	.248	.320	.417	.736
14	Padres	773	745	.509	1,518	.491	50,827	6,562	12,366	2,395	212	1,722	6,262	4,869	522	12,782	956	315	56,903	20,351	4,329	323	362	221	1,057	.243	.314	.400	.714
15	Twins	769	749	.507	1,518	.493	51,688	7,106	12,897	2,652	216	1,983	6,787	4,956	650	13,048	632	222	57,802	21,930	4,851	132	376	171	1,023	.250	.321	.424	.745
16	Giants	760	758	.501	1,518	.499	51,356	6,526	12,463	2,519	266	1,587	6,240	4,922	562	12,959	621	232	57,481	20,275	4,372	225	416	261	1,091	.243	.313	.395	.708
17	Mets	747	771	.492	1,518	.508	51,113	6,818	12,656	2,439	205	1,933	6,568	4,932	824	12,526	734	220	57,449	21,304	4,577	226	354	252	1,113	.248	.322	.417	.739
18	Phillies	742	776	.489	1,518	.511	51,367	6,896	12,773	2,521	267	1,851	6,605	4,915	564	13,199	932	255	57,435	21,381	4,639	236	353	268	1,010	.249	.319	.416	.735
19	Blue Jays	741	777	.488	1,518	.512	51,481	7,025	12,938	2,697	147	1,992	6,742	4,961	539	12,193	634	234	57,474	21,905	4,836	149	344	141	1,206	.251	.322	.425	.747
20	Mariners	727	791	.479	1,518	.521	51,138	6,794	12,342	2,336	163	1,927	6,507	5,012	785	13,465	955	309	57,435	20,785	4,426	144	356	170	1,030	.241	.317	.406	.723
21	Cardinals	723	793	.477	1,516	.523	51,014	6,861	12,691	2,486	185	1,804	6,549	4,951	704	12,475	779	260	57,344	20,959	4,475	274	401	209	1,035	.249	.321	.411	.732
22	Cubs	707	811	.466	1,519	.534	51,173	7,180	12,700	2,484	272	1,877	6,850	5,343	760	13,230	904	310	57,919	21,359	4,633	262	381	287	1,036	.248	.326	.417	.744
23	Rays	702	816	.462	1,518	.538	51,326	6,841	12,662	2,537	264	1,811	6,501	4,879	674	13,748	1,133	389	57,353	21,160	4,612	115	359	171	950	.247	.318	.412	.730
24	Red Sox	698	820	.460	1,518	.540	52,550	7,605	13,790	3,119	217	1,846	7,228	4,962	561	12,684	900	274	58,559	22,881	5,182	101	385	278	1,144	.262	.330	.435	.766
25	Braves	696	820	.459	1,516	.541	51,772	7,297	13,218	2,681	202	2,006	7,006	4,962	583	12,826	783	255	57,940	22,321	4,889	257	366	316	1,053	.255	.325	.431	.756