Between the 2010 and 2019 seasons, the Washington Nationals put up the most runs by a team in a game, with 25 runs against the Mets on July 31, 2018.

Interpreted as:

MLB team most run in a regular-season game 2010s

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Nationals	25	7/31/2018	WSH	vs	NYM	W 25-4	50	26	5	2	5	25	8	1	6	2	0	59	50	12	0	0	1	0	.520	.593	1.000	1.593
2	Mets	24	8/16/2018	NYM	@	PHI	W 24-4	52	25	7	1	3	19	7	1	5	1	0	61	43	11	1	0	1	2	.481	.550	.827	1.377
3	Astros	23	8/10/2019	HOU	@	BAL	W 23-2	50	25	7	0	6	21	2	0	4	0	0	52	50	13	0	0	0	3	.500	.519	1.000	1.519
4	Nationals	23	4/30/2017	WSH	vs	NYM	W 23-5	46	23	4	0	7	23	6	0	6	0	0	54	48	11	1	1	3	0	.500	.547	1.043	1.591
5	Marlins	22	7/26/2017	MIA	@	TEX	W 22-10	47	22	8	2	4	21	6	0	11	0	0	54	46	14	0	1	0	1	.468	.519	.979	1.497
6	Red Sox	22	8/15/2015	BOS	vs	SEA	W 22-10	47	26	7	0	4	22	6	1	3	1	0	57	45	11	0	3	0	1	.553	.579	.957	1.536
7	Yankees	22	8/25/2011	NYY	vs	OAK	W 22-9	43	21	2	1	5	22	13	1	9	0	0	58	40	8	0	1	1	0	.488	.603	.930	1.534
8	Athletics	21	9/10/2019	OAK	@	HOU	W 21-7	51	25	3	0	6	21	4	0	7	0	0	56	46	9	0	1	0	0	.490	.518	.902	1.420
9	Astros	21	9/8/2019	HOU	vs	SEA	W 21-1	47	22	11	0	2	19	7	1	8	0	0	55	39	13	0	0	0	0	.468	.545	.830	1.375
10	Athletics	21	9/20/2018	OAK	vs	LAA	W 21-3	44	22	4	0	3	20	7	0	7	0	0	51	35	7	0	0	0	2	.500	.569	.795	1.364
11	Dodgers	21	8/2/2018	LAD	vs	MIL	W 21-5	42	18	5	0	7	20	6	1	7	1	0	49	44	12	0	0	0	1	.429	.510	1.048	1.558
12	Angels	21	7/2/2016	LAA	@	BOS	W 21-2	50	22	6	1	4	19	3	1	5	0	0	55	42	11	0	1	0	0	.440	.473	.840	1.313
13	Astros	21	10/2/2015	HOU	@	ARI	W 21-5	46	19	4	1	4	18	8	0	8	1	0	57	37	9	1	2	1	0	.413	.482	.804	1.286
14	Yankees	21	7/28/2015	NYY	@	TEX	W 21-5	46	19	5	1	2	20	10	2	11	0	0	58	32	8	0	0	0	1	.413	.534	.696	1.230
15	Mariners	21	5/30/2012	SEA	@	TEX	W 21-8	47	20	7	0	4	20	6	0	8	1	0	54	39	11	0	1	0	0	.426	.481	.830	1.311
16	Diamondbacks	20	7/7/2018	ARI	vs	SDP	W 20-5	41	18	4	0	5	19	7	1	10	0	0	50	37	9	0	1	0	1	.439	.520	.902	1.422
17	Phillies	20	4/7/2018	PHI	vs	MIA	W 20-1	42	20	4	0	4	20	6	0	11	0	0	49	36	8	0	1	0	1	.476	.531	.857	1.388
18	Twins	20	6/13/2017	MIN	vs	SEA	W 20-7	49	28	2	0	5	19	2	0	4	0	0	51	45	7	0	0	0	1	.571	.588	.918	1.507
19	Yankees	20	8/30/2015	NYY	@	ATL	W 20-6	46	21	3	0	3	20	9	1	7	0	0	57	33	6	0	1	0	1	.457	.544	.717	1.261
20	Twins	20	8/22/2014	MIN	vs	DET	W 20-6	46	20	4	1	4	18	9	0	8	1	0	55	38	9	0	0	0	0	.435	.527	.826	1.353
21	Red Sox	20	9/4/2013	BOS	vs	DET	W 20-4	41	19	4	0	8	20	4	2	10	1	0	48	47	12	0	1	1	1	.463	.521	1.146	1.667
22	Athletics	20	8/31/2012	OAK	vs	BOS	W 20-2	44	19	5	0	5	20	2	1	4	0	0	47	39	10	0	0	0	0	.432	.468	.886	1.354
23	Rangers	20	7/25/2011	TEX	vs	MIN	W 20-6	52	27	8	1	2	19	4	0	4	0	0	57	43	11	0	1	1	0	.519	.544	.827	1.371
24	Brewers	20	4/22/2010	MIL	@	PIT	W 20-0	52	25	7	1	4	20	6	0	8	2	0	59	46	12	0	1	0	0	.481	.525	.885	1.410
25	Athletics	19	8/26/2019	OAK	@	KCR	W 19-4	49	22	2	1	4	19	6	0	8	0	0	55	38	7	0	0	0	0	.449	.509	.776	1.285