The New York Giants have put up the most runs by a team in a game on May 25, with 21 runs against the Pirates on May 25, 1954.

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Giants	21	5/25/1954	NYG	vs	PIT	W 21-4	44	22	3	2	3	20	9	1	1	0	0	54	38	8	0	0	2	0	.500	.593	.864	1.456
2	Orphans	20	5/25/1898	CHI	vs	BAL	W 20-4
3	Bisons	20	5/25/1882	BUF	vs	CLE	W 20-1
4	Padres	19	5/25/2019	SDP	@	TOR	W 19-4	45	20	2	0	7	19	6	3	11	1	0	54	43	9	0	0	0	2	.444	.537	.956	1.493
5	Indians	18	5/25/1934	CLE	vs	BSA	W 18-3	46	24	6	2	3	18	3	0	2	0	0	49	43	11	0				.522	.551	.935	1.486
6	Athletics	18	5/25/1886	PHA	vs	CIN	W 18-10
7	White Sox	17	5/25/2009	CWS	@	LAA	W 17-3	51	24	4	0	3	17	4	1	8	1	0	56	37	7	0	0	0	0	.471	.518	.725	1.243
8	Giants	17	5/25/1999	SFG	@	STL	W 17-1	43	17	5	0	4	15	7	1	5	0	1	52	34	9	1	0	0	1	.395	.490	.791	1.281
9	Dodgers	17	5/25/1979	LAD	vs	CIN	W 17-6	43	20	1	0	7	17	5	0	4	1	0	48	42	8	0	0	0	2	.465	.521	.977	1.498
10	Twins	17	5/25/1965	MIN	@	BOS	W 17-5	46	20	4	1	5	17	5	0	4	0	0	52	41	10	0	1	0	0	.435	.481	.891	1.372
11	Dodgers	17	5/25/1962	LAD	vs	NYM	W 17-8	41	18	3	1	1	16	6	1	7	3	1	49	26	5	0	1	0	0	.439	.510	.634	1.144
12	Yankees	17	5/25/1947	NYY	vs	BSA	W 17-2	41	17	4	1	2	15	13	0	8	0	0	54	29	7	0			0	.415	.556	.707	1.263
13	Senators	17	5/25/1926	WSH	@	PHA	W 17-12	43	16	4	1	0	13	6	0	7	2	0	49	22	5	0				.372	.449	.512	.961
14	Red Caps	17	5/25/1878	BOS	vs	PRO	W 17-10
15	Dodgers	16	5/25/2009	LAD	@	COL	W 16-6	45	19	2	1	0	16	4	0	11	2	0	51	23	3	1	1	0	0	.422	.460	.511	.971
16	Twins	16	5/25/1990	MIN	vs	BOS	W 16-0	42	19	4	3	0	14	2	0	2	0	0	46	29	7	0	2	0	3	.452	.457	.690	1.147
17	Yankees	16	5/25/1948	NYY	@	DET	W 16-5	46	22	7	1	0	15	6	0	1	0	0	53	31	8	1			2	.478	.538	.674	1.212
18	Athletics	16	5/25/1931	PHA	vs	NYY	W 16-4	38	16	5	3	1	16	8	1	4	0	2	47	30	9	0				.421	.532	.789	1.321
19	Rangers	15	5/25/2016	TEX	vs	LAA	W 15-9	40	18	3	0	1	15	5	1	6	1	0	48	24	4	1	1	2	0	.450	.511	.600	1.111
20	Phillies	15	5/25/2008	PHI	@	HOU	W 15-6	42	16	5	1	3	15	3	0	5	0	0	46	32	9	0	1	0	0	.381	.413	.762	1.175
21	Mariners	15	5/25/1999	SEA	@	MIN	W 15-5	43	17	2	0	4	15	8	0	4	1	0	52	31	6	0	1	1	0	.395	.481	.721	1.202
22	Angels	15	5/25/1995	CAL	vs	NYY	W 15-2	34	12	4	0	3	15	11	0	7	0	0	46	25	7	0	1	0	1	.353	.500	.735	1.235
23	Red Sox	15	5/25/1950	BSA	@	SLA	W 15-12	45	19	2	0	4	15	3	0	1	0	0	48	33	6	0		0	1	.422	.458	.733	1.192
24	Highlanders	15	5/25/1906	NYH	vs	DET	W 15-5	37	16	3	3	0	14	4	2	1	1		46	25	6	3				.432	.512	.676	1.187
25	Alleghenys	15	5/25/1883	PIT	@	BAL	W 15-6