The Cincinnati Reds have put up the most runs by an NL team in a game against an AL team, with 24 runs against the Orioles on April 20.

Interpreted as:

MLB team most run nl vs al in a regular-season game

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Reds	24	4/20/2025	CIN	@	BAL	W 24-2	51	25	4	1	3	23	11	2	6	1	0	64	40	8	0	0	0	1	.490	.594	.784	1.378
2	Marlins	22	7/26/2017	MIA	@	TEX	W 22-10	47	22	8	2	4	21	6	0	11	0	0	54	46	14	0	1	0	1	.468	.519	.979	1.497
3	Rockies	20	7/24/2024	COL	vs	BOS	W 20-7	45	21	4	0	4	20	2	1	10	0	0	50	37	8	0	2	0	0	.467	.480	.822	1.302
4	Dodgers	19	5/15/2025	LAD	vs	ATH	W 19-2	40	18	2	0	5	19	8	0	6	2	0	50	35	7	0	2	0	0	.450	.520	.875	1.395
5	Brewers	19	9/9/2020	MIL	@	DET	W 19-0	45	21	8	0	5	18	7	2	6	0	1	54	44	13	0	0	0	2	.467	.556	.978	1.533
6	Diamondbacks	19	7/17/2019	ARI	@	TEX	W 19-4	47	21	5	0	5	19	8	3	9	0	0	59	41	10	0	1	0	0	.447	.542	.872	1.415
7	Padres	19	5/25/2019	SDP	@	TOR	W 19-4	45	20	2	0	7	19	6	3	11	1	0	54	43	9	0	0	0	2	.444	.537	.956	1.493
8	Dodgers	18	5/31/2025	LAD	vs	NYY	W 18-2	43	21	5	0	5	18	7	0	5	0	0	51	41	10	0	1	0	1	.488	.549	.953	1.503
9	Cubs	18	3/31/2025	CHC	@	ATH	W 18-3	48	21	6	1	4	18	10	1	7	0	0	60	41	11	0	1	0	0	.438	.533	.854	1.388
10	Mets	18	9/11/2020	NYM	@	TOR	W 18-1	47	19	5	0	3	17	6	2	10	0	0	55	33	8	0	0	0	1	.404	.491	.702	1.193
11	Pirates	18	6/11/2005	PIT	vs	TBD	W 18-2	46	20	3	1	1	18	4	1	8	0	0	52	28	5	0	1	0	0	.435	.481	.609	1.089
12	Rockies	18	7/18/2000	COL	vs	OAK	W 18-3	44	21	4	0	2	17	5	0	3	0	0	51	31	6	0	2	0	1	.477	.510	.705	1.214
13	Giants	18	6/4/2000	SFG	@	OAK	W 18-2	45	19	6	0	5	17	5	0	7	0	0	51	40	11	0	1	0	1	.422	.471	.889	1.359
14	Brewers	17	6/20/2025	MIL	@	MIN	W 17-6	41	19	4	0	0	17	6	0	10	1	2	49	23	4	0	2	0	0	.463	.510	.561	1.071
15	Mets	17	4/14/2023	NYM	@	OAK	W 17-6	37	11	4	0	1	17	17	2	7	1	0	56	18	5	0	0	0	1	.297	.536	.486	1.022
16	Cubs	17	6/17/2015	CHC	@	CLE	W 17-0	43	18	2	1	4	16	5	1	6	0	0	49	34	7	0	0	0	2	.419	.490	.791	1.280
17	Nationals	17	5/20/2011	WSH	@	BAL	W 17-5	45	19	0	2	6	17	5	2	9	0	0	52	41	8	0	0	0	1	.422	.500	.911	1.411
18	Expos	17	6/19/2004	MON	vs	CWS	W 17-14	39	18	5	1	4	17	6	2	6	1	1	49	37	10	2	0	2	0	.462	.553	.949	1.502
19	Astros	17	6/30/1998	HOU	vs	CWS	W 17-2	39	18	3	0	4	17	3	0	7	0	0	43	33	7	0	1	0	2	.462	.488	.846	1.335
20	Padres	17	6/7/1998	SDP	@	TEX	W 17-8	40	15	4	0	1	17	9	0	0	0	1	49	22	5	0	0	1	1	.375	.490	.550	1.040
21	Dodgers	16	7/22/2023	LAD	@	TEX	W 16-3	41	18	3	0	5	15	7	0	9	0	0	49	36	8	0	1	0	3	.439	.510	.878	1.388
22	Giants	16	4/6/2023	SFG	@	CWS	W 16-6	47	20	3	0	5	16	5	2	9	0	0	54	38	8	0	0	0	0	.426	.500	.809	1.309
23	Padres	16	5/21/2021	SDP	vs	SEA	W 16-1	40	17	2	1	3	16	6	0	8	2	0	46	30	6	0	0	0	1	.425	.500	.750	1.250
24	Dodgers	16	8/20/2019	LAD	vs	TOR	W 16-3	37	15	5	0	5	16	10	0	8	0	0	47	35	10	0	0	1	0	.405	.532	.946	1.478
25	Mets	16	8/15/2018	NYM	@	BAL	W 16-5	44	19	4	3	3	15	5	2	6	1	0	52	38	10	0	1	0	1	.432	.500	.864	1.364