The San Diego Padres scored the most runs by a team in a game in 2021, with 24 runs versus the Nationals on July 16, 2021.

Interpreted as:

MLB team most runs in a regular-season game 2021

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	24	7/16/2021	SDP	@	WSH	W 24-8	50	22	3	1	5	23	9	0	7	3	0	60	42	9	1	0	0	0	.440	.525	.840	1.365
2	Blue Jays	22	9/12/2021	TOR	@	BAL	W 22-7	45	19	5	0	5	22	8	2	8	0	0	55	39	10	0	0	0	0	.422	.527	.867	1.394
3	Dodgers	22	7/10/2021	LAD	vs	ARI	W 22-1	44	21	2	1	8	22	8	1	4	0	0	53	49	11	0	0	0	2	.477	.566	1.114	1.680
4	Red Sox	20	8/11/2021	BOS	vs	TBR	W 20-8	42	19	7	2	1	20	9	2	6	0	0	53	33	10	0	0	2	1	.452	.566	.786	1.352
5	Braves	20	6/30/2021	ATL	vs	NYM	W 20-2	43	20	4	0	4	20	6	1	6	1	1	50	36	8	0	0	0	0	.465	.540	.837	1.377
6	Braves	20	5/21/2021	ATL	vs	PIT	W 20-1	41	20	7	0	7	20	5	0	9	0	0	49	48	14	1	2	0	0	.488	.521	1.171	1.692
7	Giants	19	5/20/2021	SFG	@	CIN	W 19-4	43	16	2	0	4	17	6	2	10	0	0	51	30	6	0	0	0	0	.372	.471	.698	1.168
8	Nationals	18	7/19/2021	WSH	vs	MIA	W 18-1	41	18	3	1	6	18	2	1	6	0	0	44	41	10	0	0	0	1	.439	.477	1.000	1.477
9	Blue Jays	18	6/13/2021	TOR	@	BOS	W 18-4	44	20	3	0	8	18	4	0	7	1	0	49	47	11	0	1	0	3	.455	.490	1.068	1.558
10	Orioles	18	6/6/2021	BAL	vs	CLE	W 18-5	43	21	3	0	2	16	3	1	6	0	0	47	30	5	0	0	0	2	.488	.532	.698	1.230
11	Phillies	17	9/16/2021	PHI	vs	CHC	W 17-8	39	16	6	0	1	17	6	2	6	0	0	48	25	7	1	0	0	1	.410	.511	.641	1.152
12	White Sox	17	8/27/2021	CWS	vs	CHC	W 17-13	41	15	5	0	2	16	9	2	2	0	0	52	26	7	0	0	0	0	.366	.500	.634	1.134
13	Athletics	17	8/12/2021	OAK	@	CLE	W 17-0	40	14	3	0	2	17	10	3	4	0	0	54	23	5	0	1	0	1	.350	.500	.575	1.075
14	Brewers	17	8/12/2021	MIL	@	CHC	W 17-4	47	22	6	1	5	17	4	1	9	1	0	53	45	12	1	0	0	0	.468	.519	.957	1.477
15	Tigers	17	7/28/2021	DET	@	MIN	W 17-14	39	16	6	1	0	17	9	0	6	0	1	51	24	7	0	3	0	0	.410	.490	.615	1.106
16	Phillies	17	6/1/2021	PHI	@	CIN	W 17-3	44	18	2	0	7	17	6	0	11	1	0	51	41	9	1	0	0	0	.409	.480	.932	1.412
17	Nationals	17	5/14/2021	WSH	@	ARI	W 17-2	51	22	6	1	3	17	5	2	5	0	0	59	39	10	1	0	0	0	.431	.500	.765	1.265
18	Red Sox	16	8/14/2021	BOS	vs	BAL	W 16-2	38	17	3	1	5	15	4	2	3	0	1	44	37	9	0	0	0	2	.447	.523	.974	1.496
19	Padres	16	5/21/2021	SDP	vs	SEA	W 16-1	40	17	2	1	3	16	6	0	8	2	0	46	30	6	0	0	0	1	.425	.500	.750	1.250
20	White Sox	16	5/17/2021	CWS	@	MIN	W 16-4	40	18	5	1	3	16	8	0	4	0	0	50	34	9	0	2	0	1	.450	.520	.850	1.370
21	Dodgers	16	5/2/2021	LAD	@	MIL	W 16-4	44	18	2	0	3	16	4	3	3	0	0	52	29	5	1	0	0	0	.409	.490	.659	1.149
22	Astros	16	4/24/2021	HOU	vs	LAA	W 16-2	42	18	7	1	3	14	5	1	7	0	0	48	36	11	0	0	1	2	.429	.500	.857	1.357
23	Cubs	16	4/21/2021	CHC	vs	NYM	W 16-4	36	13	2	0	1	15	8	1	8	1	0	45	18	3	0	0	0	1	.361	.489	.500	.989
24	Astros	15	9/13/2021	HOU	@	TEX	W 15-1	42	16	3	0	5	15	5	1	8	0	0	48	34	8	0	0	0	1	.381	.458	.810	1.268
25	Giants	15	9/11/2021	SFG	@	CHC	W 15-4	37	13	3	0	2	15	11	1	9	0	0	50	22	5	0	1	1	1	.351	.500	.595	1.095