Since 2000, the New York Yankees have the most wins by a team, with 2,380 wins.

Interpreted as:

MLB team most regular-season wins since 2000

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,380	1,726	.580	4,108	140,274	20,913	36,653	6,910	508	5,635	20,040	15,236	1,627	30,324	2,544	798	158,890	61,484	13,053	599	1,154	808	3,299	.261	.338	.438	.776
2	Dodgers	2,332	1,778	.567	4,110	139,568	19,090	35,918	7,042	704	4,641	18,213	14,133	1,539	30,050	2,399	873	157,624	58,291	12,387	1,279	1,105	1,094	3,052	.257	.330	.418	.748
3	Cardinals	2,257	1,850	.550	4,107	139,527	19,212	36,498	7,168	602	4,490	18,286	13,575	1,687	29,292	1,980	840	157,348	58,340	12,260	1,412	1,147	1,115	3,193	.262	.332	.418	.750
4	Red Sox	2,234	1,875	.544	4,109	142,689	20,914	38,322	8,537	661	4,831	19,919	14,423	1,512	30,478	2,187	726	160,350	62,674	14,029	499	1,227	976	3,253	.269	.339	.439	.779
5	Braves	2,228	1,878	.543	4,107	140,140	19,083	36,305	7,244	620	4,662	18,235	13,744	1,344	31,032	2,039	802	157,621	58,775	12,526	1,362	1,031	1,065	3,150	.259	.329	.419	.748
6	Guardians	2,134	1,973	.520	4,107	139,894	19,150	36,025	7,492	645	4,454	18,255	13,685	1,608	29,924	2,512	893	157,224	58,169	12,591	844	1,193	790	3,075	.258	.328	.416	.744
7	Giants	2,133	1,974	.519	4,108	139,666	17,988	35,583	7,149	869	4,008	17,124	13,242	1,341	29,597	1,835	772	156,742	56,494	12,026	1,326	1,167	1,248	3,192	.255	.323	.404	.727
8	Astros	2,116	1,992	.515	4,109	139,750	18,894	36,028	7,196	632	4,730	18,028	13,217	1,569	29,969	2,347	930	156,786	58,678	12,558	1,152	1,098	828	3,265	.258	.326	.420	.746
9	Phillies	2,115	1,994	.515	4,109	140,380	18,898	35,746	7,175	811	4,611	18,035	13,894	1,540	31,554	2,654	710	158,042	58,376	12,597	1,210	1,018	1,143	2,832	.255	.326	.416	.742
10	Athletics	2,106	2,002	.513	4,108	139,759	18,688	34,888	7,210	589	4,545	17,816	14,179	1,464	30,297	1,954	639	157,052	56,911	12,344	544	1,106	620	3,223	.250	.323	.407	.730
11	Angels	2,106	2,004	.512	4,110	140,122	18,861	36,267	6,913	666	4,474	17,961	12,495	1,498	28,957	2,744	1,075	156,079	57,934	12,053	826	1,138	891	3,145	.259	.324	.413	.737
12	Blue Jays	2,071	2,038	.504	4,109	140,642	19,468	36,345	7,619	586	5,023	18,603	13,191	1,481	29,514	1,982	735	156,999	60,205	13,228	582	1,103	606	3,293	.258	.326	.428	.754
13	Mariners	2,065	2,045	.502	4,110	140,090	18,097	35,396	6,680	584	4,341	17,227	12,968	1,546	31,025	2,659	947	156,459	56,267	11,605	788	1,067	789	2,946	.253	.321	.402	.722
14	Cubs	2,061	2,047	.502	4,109	139,656	18,530	35,404	7,136	734	4,651	17,654	13,459	1,601	32,105	2,122	860	157,058	57,961	12,521	1,329	1,013	960	3,002	.254	.324	.415	.739
15	Mets	2,059	2,049	.501	4,108	139,227	18,068	35,130	6,941	664	4,373	17,253	13,458	1,663	30,310	2,494	822	156,685	56,518	11,978	1,298	1,039	1,067	3,049	.252	.323	.406	.729
16	Brewers	2,057	2,053	.500	4,111	138,951	18,386	34,916	7,028	685	4,725	17,555	13,572	1,710	33,269	2,789	944	156,473	57,489	12,438	1,245	995	931	3,083	.251	.323	.414	.737
17	Twins	2,054	2,057	.500	4,111	140,875	18,953	36,559	7,392	781	4,265	17,979	13,125	1,444	30,046	2,175	887	157,274	58,308	12,438	699	1,131	759	3,192	.260	.327	.414	.740
18	Rays	2,036	2,072	.496	4,108	139,530	18,308	35,253	7,057	791	4,378	17,434	13,270	1,608	32,261	3,150	1,139	156,176	57,026	12,226	670	1,098	647	2,817	.253	.322	.409	.731
19	Rangers	2,018	2,093	.491	4,111	141,131	19,951	36,737	7,271	670	5,066	19,008	12,786	1,501	30,736	2,522	894	157,293	60,546	13,007	736	1,139	698	2,942	.260	.326	.429	.755
20	Diamondbacks	2,002	2,108	.487	4,110	140,102	18,723	35,602	7,370	1,003	4,384	17,862	13,647	1,370	31,287	2,375	853	157,529	58,130	12,757	1,248	1,162	1,021	2,939	.254	.324	.415	.739
21	Padres	1,978	2,133	.481	4,111	138,712	17,354	34,341	6,654	735	3,947	16,500	13,591	1,285	31,699	2,550	902	155,882	54,306	11,336	1,223	1,071	869	2,961	.248	.318	.392	.710
22	White Sox	1,971	2,139	.480	4,110	139,810	18,498	35,855	6,781	568	4,757	17,732	11,944	1,556	30,260	2,273	995	155,237	58,043	12,106	889	1,038	554	3,180	.256	.320	.415	.735
23	Reds	1,944	2,166	.473	4,112	139,332	18,310	35,021	6,928	619	4,694	17,475	13,510	1,731	32,552	2,591	972	156,978	57,269	12,241	1,400	1,005	942	2,912	.251	.323	.411	.734
24	Nationals	1,944	2,164	.473	4,108	138,786	17,846	35,338	7,180	681	4,101	16,975	13,101	1,474	30,394	2,554	991	155,884	56,183	11,962	1,473	1,050	1,039	3,127	.255	.323	.405	.728
25	Tigers	1,928	2,177	.470	4,105	140,658	18,343	36,570	7,004	974	4,249	17,549	12,086	1,271	30,950	1,856	834	155,875	58,269	12,227	739	1,121	681	3,153	.260	.322	.414	.736