Since 2021, the Colorado Rockies have the fewest wins by a team, with 305 wins.

Interpreted as:

MLB team with least regular-season wins since 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	305	504	.377	809	27,272	3,437	6,714	1,390	161	833	3,299	2,239	277	7,377	369	138	30,094	10,925	2,384	109	197	67	605	.246	.308	.401	.708
2	Nationals	328	482	.405	810	27,137	3,374	6,760	1,328	112	765	3,209	2,337	352	6,244	613	207	30,134	10,607	2,205	122	186	83	629	.249	.315	.391	.706
3	White Sox	336	474	.415	810	27,229	3,277	6,553	1,280	63	808	3,139	2,244	295	6,849	376	106	30,030	10,383	2,151	96	166	54	612	.241	.304	.381	.685
4	Athletics	341	469	.421	810	26,999	3,272	6,288	1,281	90	922	3,126	2,471	339	7,142	493	128	30,103	10,515	2,293	104	190	61	555	.233	.303	.389	.693
5	Pirates	346	464	.427	810	26,925	3,140	6,267	1,229	133	718	2,991	2,576	275	7,217	487	158	30,071	9,916	2,080	104	191	80	513	.233	.304	.368	.673
6	Angels	358	452	.442	810	27,080	3,393	6,378	1,171	112	1,002	3,244	2,397	365	7,500	449	161	30,096	10,779	2,285	88	166	116	534	.236	.305	.398	.703
7	Marlins	361	449	.446	810	27,305	3,221	6,643	1,247	118	772	3,069	2,201	294	6,926	577	166	30,088	10,442	2,137	99	189	83	587	.243	.305	.382	.687
8	Royals	363	447	.448	810	27,144	3,388	6,686	1,312	167	793	3,260	2,156	295	6,198	636	187	29,961	10,711	2,272	117	249	68	488	.246	.306	.395	.701
9	Rangers	377	433	.465	810	27,393	3,580	6,609	1,240	92	949	3,423	2,464	276	6,854	544	147	30,372	10,880	2,281	53	186	78	486	.241	.308	.397	.706
10	Diamondbacks	379	431	.468	810	27,278	3,804	6,717	1,392	174	908	3,621	2,722	337	6,634	552	140	30,765	11,181	2,474	170	258	87	538	.246	.320	.410	.729
11	Reds	387	423	.478	810	27,075	3,632	6,550	1,305	120	917	3,461	2,584	427	7,229	596	180	30,376	10,846	2,342	96	194	58	549	.242	.316	.401	.716
12	Twins	390	420	.481	810	27,318	3,623	6,650	1,362	102	1,013	3,448	2,605	413	7,090	357	107	30,585	11,255	2,477	48	201	66	594	.243	.317	.412	.729
13	Tigers	394	416	.486	810	27,130	3,355	6,450	1,204	176	814	3,220	2,365	268	7,315	357	112	30,028	10,448	2,194	49	216	50	508	.238	.303	.385	.688
14	Orioles	402	408	.496	810	27,327	3,603	6,640	1,363	120	975	3,453	2,412	332	7,030	482	140	30,335	11,168	2,458	57	207	65	487	.243	.310	.409	.719
15	Cubs	403	407	.498	810	27,171	3,710	6,636	1,279	145	958	3,545	2,679	369	7,074	641	173	30,534	11,079	2,382	101	214	79	519	.244	.318	.408	.726
16	Cardinals	415	395	.512	810	27,297	3,558	6,759	1,336	85	917	3,406	2,541	380	6,532	466	132	30,531	11,016	2,338	100	213	87	539	.248	.318	.404	.722
17	Red Sox	418	392	.516	810	27,735	3,873	7,116	1,656	108	936	3,693	2,487	340	7,120	487	149	30,823	11,796	2,700	53	208	114	558	.257	.323	.425	.748
18	Mets	425	385	.525	810	27,029	3,659	6,657	1,262	100	993	3,512	2,607	492	6,647	487	103	30,420	11,098	2,355	98	194	100	574	.246	.322	.411	.732
19	Giants	428	382	.528	810	27,101	3,592	6,456	1,287	114	948	3,435	2,765	358	7,247	323	92	30,536	10,815	2,349	91	221	107	560	.238	.315	.399	.714
20	Guardians	428	381	.529	809	27,023	3,428	6,520	1,303	118	807	3,261	2,334	347	6,191	656	160	30,029	10,480	2,228	100	225	154	517	.241	.307	.388	.695
21	Padres	433	377	.535	810	27,203	3,648	6,764	1,334	89	880	3,485	2,781	297	6,200	522	151	30,644	10,916	2,303	151	212	118	586	.249	.323	.401	.724
22	Blue Jays	440	370	.543	810	27,510	3,836	7,109	1,458	83	997	3,688	2,576	318	6,095	396	130	30,665	11,724	2,538	71	190	84	636	.258	.327	.426	.753
23	Rays	442	368	.546	810	27,289	3,701	6,677	1,353	116	920	3,515	2,560	348	7,239	715	221	30,427	11,022	2,389	45	185	72	473	.245	.315	.404	.719
24	Mariners	443	367	.547	810	27,062	3,587	6,318	1,206	64	1,029	3,440	2,794	477	7,563	566	146	30,583	10,739	2,299	60	190	81	515	.233	.314	.397	.711
25	Phillies	450	360	.556	810	27,454	3,839	6,947	1,361	130	1,033	3,693	2,624	310	6,953	595	133	30,694	11,667	2,524	95	211	114	531	.253	.323	.425	.748