Since 2000, the New York Yankees have the most wins by a team, with 2,306 wins.

Interpreted as:

MLB team with most regular-season wins since 2000

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	2,306	1,674	.579	3,982	136,019	20,266	35,600	6,718	493	5,421	19,415	14,741	1,590	29,180	2,437	770	154,053	59,567	12,632	592	1,111	768	3,218	.262	.338	.438	.776
2	Dodgers	2,263	1,721	.568	3,984	135,298	18,458	34,845	6,845	690	4,455	17,608	13,686	1,495	29,001	2,338	854	152,808	56,435	11,990	1,267	1,062	1,065	2,970	.258	.330	.417	.747
3	Cardinals	2,198	1,785	.552	3,983	135,388	18,697	35,504	6,979	594	4,377	17,798	13,231	1,613	28,261	1,918	821	152,737	56,802	11,950	1,390	1,115	1,106	3,111	.262	.333	.420	.752
4	Braves	2,169	1,810	.545	3,980	135,810	18,500	35,240	7,052	604	4,512	17,669	13,290	1,302	29,958	1,979	782	152,750	57,036	12,168	1,349	999	1,052	3,073	.259	.329	.420	.749
5	Red Sox	2,163	1,821	.543	3,984	138,407	20,308	37,232	8,285	642	4,687	19,342	14,039	1,455	29,399	2,091	695	155,584	60,862	13,614	488	1,195	961	3,171	.269	.340	.440	.780
6	Giants	2,076	1,907	.521	3,984	135,552	17,466	34,620	6,973	846	3,874	16,626	12,821	1,286	28,543	1,789	756	152,093	54,907	11,693	1,310	1,124	1,236	3,110	.255	.323	.405	.728
7	Guardians	2,068	1,914	.519	3,982	135,795	18,664	35,114	7,299	629	4,328	17,780	13,313	1,562	28,870	2,412	868	152,652	56,655	12,256	822	1,160	765	3,017	.259	.329	.417	.746
8	Athletics	2,050	1,934	.515	3,984	135,515	18,120	33,821	6,973	579	4,373	17,265	13,793	1,426	29,172	1,891	616	152,344	55,071	11,925	529	1,081	608	3,141	.250	.323	.406	.729
9	Angels	2,048	1,934	.514	3,982	135,865	18,313	35,300	6,744	652	4,295	17,434	12,086	1,424	27,654	2,675	1,053	151,301	56,233	11,691	816	1,110	873	3,068	.260	.324	.414	.738
10	Astros	2,047	1,935	.514	3,983	135,451	18,353	34,943	6,997	624	4,579	17,510	12,860	1,512	28,950	2,283	909	152,035	56,925	12,200	1,143	1,069	818	3,167	.258	.327	.420	.747
11	Phillies	2,039	1,943	.512	3,982	136,054	18,287	34,627	6,960	793	4,436	17,439	13,504	1,493	30,494	2,563	687	153,231	56,481	12,189	1,196	984	1,130	2,764	.255	.326	.415	.742
12	Twins	2,000	1,985	.502	3,985	136,640	18,417	35,548	7,206	765	4,104	17,472	12,732	1,377	28,961	2,081	861	152,544	56,596	12,075	690	1,105	750	3,109	.260	.327	.414	.741
13	Mets	2,000	1,984	.502	3,984	135,041	17,483	34,088	6,750	655	4,191	16,681	13,037	1,597	29,265	2,371	809	151,959	54,721	11,596	1,284	1,000	1,045	2,963	.252	.323	.405	.729
14	Mariners	1,997	1,987	.501	3,984	135,813	17,516	34,353	6,495	577	4,154	16,670	12,580	1,479	29,885	2,541	922	151,680	54,464	11,226	770	1,038	763	2,864	.253	.321	.401	.722
15	Blue Jays	1,993	1,989	.501	3,982	136,299	18,793	35,161	7,384	574	4,857	17,950	12,780	1,432	28,670	1,929	718	152,134	58,264	12,815	553	1,070	586	3,183	.258	.326	.427	.753
16	Cubs	1,991	1,993	.500	3,985	135,496	17,960	34,377	6,937	714	4,483	17,102	13,054	1,566	31,135	2,009	833	152,409	56,191	12,134	1,324	969	947	2,947	.254	.324	.415	.739
17	Brewers	1,979	2,007	.496	3,987	134,695	17,755	33,790	6,814	671	4,590	16,960	13,139	1,654	32,306	2,671	902	151,672	55,716	12,075	1,229	955	922	3,008	.251	.323	.414	.737
18	Rays	1,975	2,006	.496	3,981	135,231	17,729	34,164	6,868	778	4,225	16,884	12,913	1,570	31,162	2,997	1,097	151,435	55,263	11,871	654	1,067	637	2,737	.253	.323	.409	.731
19	Rangers	1,955	2,030	.491	3,985	136,851	19,386	35,734	7,074	659	4,922	18,466	12,384	1,448	29,692	2,416	870	152,518	58,892	12,655	727	1,108	681	2,872	.261	.327	.430	.757
20	Diamondbacks	1,941	2,044	.487	3,985	135,864	18,118	34,531	7,168	971	4,216	17,275	13,253	1,304	30,257	2,285	822	152,754	56,289	12,355	1,218	1,115	1,004	2,857	.254	.324	.414	.738
21	White Sox	1,921	2,063	.482	3,984	135,598	17,978	34,858	6,582	559	4,618	17,229	11,572	1,516	29,202	2,216	981	150,567	56,412	11,759	871	1,010	547	3,091	.257	.320	.416	.736
22	Padres	1,911	2,073	.480	3,984	134,429	16,792	33,267	6,453	720	3,824	15,965	13,193	1,236	30,777	2,476	881	151,078	52,632	10,997	1,184	1,036	855	2,884	.247	.318	.392	.710
23	Nationals	1,895	2,089	.476	3,984	134,630	17,327	34,332	6,978	659	3,978	16,477	12,778	1,433	29,347	2,463	954	151,322	54,562	11,615	1,462	1,019	1,028	3,041	.255	.324	.405	.729
24	Reds	1,879	2,106	.472	3,987	135,127	17,771	33,989	6,733	599	4,564	16,968	13,119	1,696	31,459	2,528	954	152,300	55,612	11,896	1,390	968	930	2,825	.252	.323	.412	.735
25	Tigers	1,863	2,115	.468	3,978	136,385	17,764	35,526	6,806	944	4,098	16,999	11,700	1,221	29,808	1,810	820	151,124	56,514	11,848	738	1,080	672	3,082	.260	.322	.414	.737