Between the 2005 and 2022 seasons, the New York Yankees had the most wins by a team, with 1,623 wins.

Interpreted as:

MLB teams most regular-season wins from 2005 to 2022

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	1,623	1,191	.577	2,814	96,164	14,230	25,153	4,709	367	3,802	13,616	10,224	1,122	20,871	1,680	499	108,736	42,002	8,878	438	788	495	2,224	.262	.337	.437	.774
2	Dodgers	1,599	1,215	.568	2,814	95,513	12,913	24,639	4,889	498	3,016	12,292	9,749	1,040	20,840	1,608	602	107,957	39,572	8,403	921	734	774	2,121	.258	.331	.414	.745
3	Cardinals	1,550	1,261	.551	2,811	95,417	12,913	24,879	4,904	421	2,949	12,286	9,175	1,133	20,021	1,241	548	107,424	39,472	8,274	952	747	778	2,244	.261	.330	.414	.744
4	Red Sox	1,533	1,281	.545	2,814	97,624	14,272	26,231	5,839	429	3,267	13,565	9,971	990	20,891	1,467	460	109,777	42,729	9,535	342	850	678	2,291	.269	.340	.438	.778
5	Braves	1,478	1,334	.526	2,812	95,832	12,751	24,619	4,993	420	3,022	12,182	9,368	902	21,743	1,293	535	107,750	39,518	8,435	978	670	766	2,152	.257	.327	.412	.739
6	Guardians	1,475	1,337	.525	2,812	95,807	12,994	24,659	5,210	432	3,010	12,399	9,378	1,090	21,038	1,660	549	107,659	39,763	8,652	564	820	530	2,098	.257	.328	.415	.743
7	Angels	1,473	1,341	.523	2,814	95,883	12,836	24,785	4,761	446	2,994	12,228	8,521	919	19,780	1,853	705	106,639	39,420	8,201	545	771	634	2,225	.258	.323	.411	.734
8	Rays	1,461	1,354	.519	2,815	95,390	12,623	24,031	4,851	566	3,121	12,023	9,436	1,115	22,732	2,037	770	107,149	39,377	8,538	430	778	458	1,935	.252	.324	.413	.737
9	Brewers	1,443	1,372	.513	2,815	95,086	12,620	23,950	4,857	478	3,361	12,064	9,125	1,206	22,830	1,810	612	106,965	39,846	8,696	874	674	664	2,095	.252	.323	.419	.742
10	Phillies	1,431	1,383	.509	2,814	96,071	12,745	24,281	4,779	574	3,127	12,150	9,214	1,096	21,741	1,710	448	107,908	39,589	8,480	854	673	803	1,929	.253	.323	.412	.735
11	Athletics	1,428	1,385	.508	2,813	95,553	12,535	23,668	4,902	421	2,951	11,916	9,523	960	20,746	1,378	454	107,160	38,265	8,274	361	763	365	2,210	.248	.320	.400	.720
12	Mets	1,424	1,390	.506	2,814	95,583	12,352	24,230	4,836	505	2,913	11,796	9,149	1,089	20,935	1,727	577	107,448	38,815	8,254	910	717	774	2,067	.253	.324	.406	.730
13	Astros	1,423	1,390	.506	2,814	95,511	12,499	24,355	4,910	419	3,134	11,930	8,758	986	20,863	1,658	658	106,744	39,505	8,463	759	730	504	2,206	.255	.322	.414	.735
14	Giants	1,420	1,393	.505	2,813	95,789	11,804	24,315	4,885	617	2,462	11,207	8,402	864	20,336	1,336	548	106,723	37,820	7,964	901	767	726	2,211	.254	.317	.395	.712
15	Blue Jays	1,420	1,394	.505	2,814	96,050	13,199	24,629	5,186	366	3,527	12,629	9,034	921	20,453	1,323	497	107,172	41,128	9,079	418	749	375	2,249	.256	.324	.428	.752
16	Cubs	1,406	1,406	.500	2,813	95,590	12,422	24,191	4,938	509	3,078	11,809	9,014	1,156	22,371	1,316	608	107,239	39,381	8,525	845	634	654	2,128	.253	.323	.412	.735
17	Rangers	1,393	1,422	.495	2,815	96,391	13,436	25,015	4,923	467	3,367	12,773	8,541	1,018	21,488	1,850	643	107,261	40,973	8,757	541	770	459	2,024	.260	.324	.425	.749
18	Twins	1,385	1,431	.492	2,816	96,429	12,887	24,967	4,941	522	2,865	12,240	9,015	881	20,512	1,385	548	107,607	39,547	8,328	497	785	540	2,196	.259	.325	.410	.736
19	White Sox	1,381	1,433	.491	2,814	95,916	12,415	24,631	4,547	407	3,179	11,900	7,990	1,137	21,213	1,540	707	106,307	39,529	8,133	566	698	391	2,204	.257	.319	.412	.731
20	Nationals	1,368	1,444	.486	2,812	95,164	12,310	24,284	4,876	458	2,888	11,722	9,232	1,051	21,536	1,586	601	107,172	38,740	8,222	987	738	705	2,154	.255	.326	.407	.733
21	Tigers	1,362	1,448	.485	2,810	96,606	12,702	25,484	4,923	631	2,930	12,159	8,239	850	21,330	1,169	515	106,936	40,459	8,484	489	752	521	2,255	.264	.325	.419	.744
22	Mariners	1,346	1,468	.478	2,814	95,729	11,756	23,821	4,475	402	2,914	11,185	8,209	962	21,239	1,589	617	106,074	37,842	7,791	513	661	500	2,018	.249	.313	.395	.708
23	Padres	1,341	1,474	.476	2,815	94,700	11,491	23,051	4,512	529	2,679	10,935	9,012	884	22,655	1,728	607	106,217	36,658	7,720	910	711	609	1,945	.243	.313	.387	.700
24	Diamondbacks	1,339	1,475	.476	2,814	95,920	12,539	24,115	5,101	679	2,954	11,950	9,256	901	22,388	1,581	560	107,651	39,436	8,734	828	746	703	1,985	.251	.321	.411	.732
25	Reds	1,328	1,486	.472	2,815	95,345	12,399	23,963	4,724	402	3,234	11,844	9,198	1,146	22,162	1,613	646	107,396	39,193	8,360	1,013	694	667	2,006	.251	.322	.411	.734