Lou Gehrig has the most career runs by a first baseman, with 1,888 runs.

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Lou Gehrig L. Gehrig	1,888	2,164	8,001	2,721	534	163	493	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.447	.632	1.080	2265	1,046.8	.477	173	980
2	Jimmie Foxx J. Foxx	1,656	2,148	7,673	2,498	425	114	521	1,836	1,389	12	1,256	83		9,131	4,714	1,060	57			69	.326	.430	.614	1.044	2036	900.3	.463	159	752
3	Jake Beckley J. Beckley	1,602	2,389	9,538	2,934	473	244	87	1,578	616	183	442	315		10,504	4,156	804	167				.308	.361	.436	.797	1803	356.2	.376	119	288.8
4	Cap Anson C. Anson	1,552	2,092	8,279	2,727	489	114	95	1,306	919	32	146	247		9,264	3,729	698	34				.329	.398	.450	.849	1973	596.5	.399	134	475.5
5	Jeff Bagwell J. Bagwell	1,517	2,150	7,797	2,314	488	32	449	1,529	1,401	128	1,558	202	78	9,431	4,213	969	3	102	155	221	.297	.408	.540	.948	1755	596.6	.405	149	588.3
6	Roger Connor R. Connor	1,469	1,799	6,980	2,203	395	221	131	1,071	951	39	151	244		7,979	3,433	747	9				.316	.401	.492	.892	1773	571.8	.414	142	519.1
7	Dan Brouthers D. Brouthers	1,463	1,608	6,441	2,210	442	196	98	994	822	105	83	256		7,388	3,338	736	20				.343	.426	.518	.944	1810	703.6	.437	155	632.9
8	Todd Helton T. Helton	1,388	2,212	7,869	2,493	590	36	364	1,395	1,327	57	1,164	37	28	9,349	4,247	990	3	93	185	185	.317	.415	.540	.955	1750	610.4	.406	132	390.6
9	Rafael Palmeiro R. Palmeiro	1,359	2,261	8,472	2,434	474	29	459	1,480	1,110	74	1,136	78	31	9,767	4,343	962	13	98	142	193	.287	.371	.513	.884	1595	418.3	.379	130	367.8
10	Freddie Freeman F. Freeman	1,340	2,102	7,820	2,348	529	32	352	1,274	1,039	110	1,694	98	31	9,033	3,997	913	0	64	140	166	.300	.387	.511	.898	1546	492.5	.382	142	459.5
11	Eddie Murray E. Murray	1,339	2,438	9,123	2,647	461	31	414	1,574	1,139	17	1,181	92	37	10,382	4,412	906	2	101	199	244	.290	.366	.484	.850	1594	423.6	.372	134	407.4
12	Albert Pujols A. Pujols	1,332	2,096	7,766	2,307	479	9	494	1,485	999	76	899	100	32	8,925	4,286	982	0	84	265	291	.297	.379	.552	.931	1554	497.4	.389	144	489.6
13	George Sisler G. Sisler	1,284	2,055	8,267	2,812	425	164	102	1,178	472	48	327	375		9,013	3,871	691	226				.340	.379	.468	.847	1424	363.9	.393	123	244.2
14	Fred McGriff F. McGriff	1,283	2,323	8,385	2,403	422	24	471	1,500	1,236	38	1,757	69	36	9,732	4,286	917	2	71	165	222	.287	.378	.511	.889	1613	444.1	.384	135	408.1
15	Paul Goldschmidt P. Goldschmidt	1,252	2,006	7,404	2,138	461	24	370	1,219	1,074	51	1,936	174	35	8,585	3,757	855	0	56	119	170	.289	.380	.507	.888	1440	435.1	.378	138	391.1
16	Joe Kuhel J. Kuhel	1,236	2,101	7,981	2,212	412	111	131	1,049	980	39	609	178		9,092	3,239	654	92			74	.277	.359	.406	.765	1233	156.4	.357	105	59
17	Mickey Vernon M. Vernon	1,196	2,400	8,723	2,494	490	120	172	1,310	954	49	869	137	31	9,825	3,740	782	80	19	21	183	.286	.359	.429	.788	1349	230.2	.363	115	169.6
18	Will Clark W. Clark	1,186	1,976	7,173	2,176	440	47	284	1,205	937	59	1,190	67	48	8,283	3,562	771	13	101	155	100	.303	.384	.497	.880	1356	372.4	.381	136	356.6
19	Joe Judge J. Judge	1,184	2,171	7,898	2,352	433	159	71	1,034	965	51	478	213		9,171	3,316	663	257				.298	.378	.420	.798	1337	245.9	.374	116	184.3
20	Mark Grace M. Grace	1,179	2,245	8,065	2,445	511	45	173	1,146	1,075	34	642	70	48	9,290	3,565	729	17	99	114	192	.303	.383	.442	.825	1393	277.1	.364	120	225.5
21	Jim Bottomley J. Bottomley	1,177	1,991	7,471	2,313	465	151	219	1,422	664	43	591	58		8,355	3,737	835	177				.310	.369	.500	.869	1377	325.4	.393	124	259.7
22	Joey Votto J. Votto	1,171	2,056	7,252	2,135	459	22	356	1,144	1,365	81	1,640	80	29	8,746	3,706	837	0	48	147	168	.294	.409	.511	.920	1563	539.6	.394	145	472.9
23	Mark McGwire M. McGwire	1,157	1,856	6,134	1,616	251	6	580	1,405	1,313	74	1,578	12	7	7,602	3,619	837	3	78	150	147	.263	.395	.590	.985	1475	566.5	.416	158	559.7
24	Fred Tenney F. Tenney	1,156	1,830	6,988	2,033	240	72	17	597	802	62	458	255		8,103	2,468	329	251				.291	.369	.353	.722	1135	191.6	.354	111	108.8
25	Lu Blue L. Blue	1,152	1,615	5,904	1,696	319	109	44	695	1,092	43	436	151		7,207	2,365	472	168				.287	.402	.401	.803	1102	191.5	.380	112	118