Since 2000, Joe Randa and Shawn Green are tied for the most runs in a game, with 6 runs.

Interpreted as:

most combined runs by a player in a regular-season game since 2000

	NAME	R	DATE	TM		OPP	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Joe Randa J. Randa	6	9/9/2004	KCR	@	DET	7	6	1	0	0	2	0	0	1	0	0	7	7	1	0	0	0	0
2	Shawn Green S. Green	6	5/23/2002	LAD	@	MIL	6	6	1	0	4	7	0	0	0	0	0	6	19	5	0	0	0	0
3	Mickey Moniak M. Moniak	5	6/24/2023	LAA	@	COL	5	5	3	0	1	4	0	1	0	0	0	6	11	4	0	0	0	0
4	Adolis García A. García	5	4/22/2023	TEX	vs	OAK	5	5	2	0	3	8	0	1	0	0	0	6	16	5	0	0	0	0
5	Trevor Story T. Story	5	5/19/2022	BOS	vs	SEA	4	4	0	0	3	7	1	0	0	1	0	5	13	3	0	0	0	0
6	Lourdes Gurriel Jr. L. Gurriel Jr.	5	9/12/2021	TOR	@	BAL	3	2	0	0	2	7	3	0	1	0	0	6	8	2	0	0	0	0
7	Luis Urías L. Urías	5	8/12/2021	MIL	@	CHC	6	5	3	0	2	5	0	0	0	0	0	6	14	5	0	0	0	0
8	Tommy Pham T. Pham	5	7/16/2021	SDP	@	WSH	6	4	1	0	1	2	1	0	0	1	0	7	8	2	0	0	0	0
9	Bo Bichette B. Bichette	5	6/13/2021	TOR	@	BOS	5	4	1	0	1	3	1	0	0	1	0	6	8	2	0	0	0	0
10	Chris Taylor C. Taylor	5	5/2/2021	LAD	@	MIL	3	3	0	0	0	0	1	2	0	0	0	6	3	0	0	0	0	0
11	José Abreu J. Abreu	5	9/12/2020	CWS	vs	DET	4	4	0	0	2	7	1	0	0	0	0	5	10	2	0	0	0	0
12	Adam Duvall A. Duvall	5	9/9/2020	ATL	vs	MIA	4	3	0	0	3	9	2	0	1	0	0	6	12	3	0	0	0	0
13	Dansby Swanson D. Swanson	5	9/9/2020	ATL	vs	MIA	4	3	0	0	0	0	1	1	1	1	0	6	3	0	0	0	0	0
14	Austin Riley A. Riley	5	9/9/2020	ATL	vs	MIA	4	2	0	0	0	1	2	0	0	0	0	6	2	0	0	0	0	0
15	Alex Dickerson A. Dickerson	5	9/1/2020	SFG	@	COL	6	5	2	0	3	6	1	0	1	0	0	7	16	5	0	0	0	0
16	George Springer G. Springer	5	5/12/2019	HOU	vs	TEX	5	5	0	0	2	4	0	0	0	0	0	5	11	2	0	0	0	0
17	Matt Carpenter M. Carpenter	5	6/26/2018	STL	vs	CLE	5	5	1	0	2	3	0	0	0	0	0	5	12	3	0	0	0	0
18	Jeimer Candelario J. Candelario	5	4/25/2018	DET	@	PIT	6	3	1	0	1	1	0	0	1	0	0	6	7	2	0	0	0	0
19	Mookie Betts M. Betts	5	4/10/2018	BOS	vs	NYY	4	4	2	0	1	4	1	0	0	0	0	5	9	3	0	0	0	0
20	Yoán Moncada Y. Moncada	5	9/14/2017	CWS	@	DET	5	4	0	0	1	1	2	0	1	1	0	7	7	1	0	0	0	0
21	Eric Hosmer E. Hosmer	5	7/26/2017	KCR	@	DET	6	5	0	0	1	6	0	0	0	1	0	6	8	1	0	0	0	0
22	Anthony Rendon A. Rendon	5	4/30/2017	WSH	vs	NYM	6	6	1	0	3	10	0	0	0	0	0	6	16	4	0	0	0	0
23	C.J. Cron	5	7/2/2016	LAA	@	BOS	6	6	1	0	2	5	0	0	0	0	0	6	13	3	0	0	0	0
24	Kendrys Morales K. Morales	5	9/20/2015	KCR	@	DET	4	4	0	1	3	3	1	0	0	0	0	5	15	4	0	0	0	0
25	Yoenis Cespedes Y. Cespedes	5	8/21/2015	NYM	@	COL	6	5	1	0	3	7	0	0	0	1	0	6	15	4	0	0	0	0