Nelson Greene has given up the most earned runs by a relief pitcher in a game, with 15 earned runs versus the Pirates on June 20, 1925.

Interpreted as:

most er by a relief pitcher in a regular-season game

	NAME	ER	DATE	TM		OPP	DEC	GS	ERA	SO	CG	SHO	SV	IP	H	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Nelson Greene N. Greene	15	6/20/1925	BKN	@	PIT		0	20.25	0	0	0	0	6.2	18	15	3	3	0	1		40	1
2	Vin Mazzaro V. Mazzaro	14	5/16/2011	KCR	vs	CLE		0	54.00	2	0	0	0	2.1	11	14	1	3	0	0	0	21	1
3	Les McCrabb L. McCrabb	14	4/16/1942	PHA	@	BSA		0	31.50	0	0	0	0	4.0	14	14	2	2	1	1		29	1
4	Carl Doyle C. Doyle	14	6/8/1940	BKN	@	CIN		0	31.50	2	0	0	0	4.0	16	14	1	4	4	0		36	2
5	Dutch Schesler D. Schesler	14	7/11/1931	PHN	vs	NYG		0	15.75	1	0	0	0	8.0	22	16	4	0	1	1		48	0
6	Bill Bernhard B. Bernhard	14	5/2/1901	PHA	vs	BSA		0	15.75	0	0	0	0	8.0	19	18	0	3	0	1			0
7	Red Evans R. Evans	13	7/1/1936	CWS	vs	DET		0	18.47	2	0	0	0	6.1	16	14	1	4	0	0		39	0
8	Eddie Rommel E. Rommel	13	7/10/1932	PHA	@	CLE	W	0	6.88	7	0	0	0	17.0	29	14	0	9	0	1		87	2
9	Dan Dugan D. Dugan	13	6/5/1929	CWS	@	BSA		0	31.91	3	0	0	0	3.2	15	13	0	2	0	0		28	0
10	Buck Freeman B. Freeman	13	6/21/1921	CHC	@	SLN	L	0	20.65	1	0	0	0	5.2	11	13	1	7	0	1		33	1
11	Elam Vangilder E. Vangilder	13	7/25/1920	SLA	@	DET		0	16.71	2	0	0	0	7.0	16	14	0	4	0	1		41	0
12	Hugh Canavan H. Canavan	13	7/6/1918	BSN	@	PIT		0	43.88	0	0	0	0	2.2	13	13	0	3	1	1		23	0
13	Jordan Yamamoto J. Yamamoto	12	9/9/2020	MIA	@	ATL		0	40.50	3	0	0	0	2.2	11	13	4	2	0	0	0	22	0
14	Bubba Harris B. Harris	12	7/4/1948	PHA	@	BSA	L	0	162.00	0	0	0	0	0.2	6	12	0	5	0	0		14	0
15	Joe Krakauskas J. Krakauskas	12	9/27/1940	WSH	@	BSA		0	21.60	4	0	0	0	5.0	13	12	1	5	0	1		31	1
16	James DeShong J. DeShong	12	6/10/1939	WSH	@	DET		0	14.73	1	0	0	0	7.1	13	12	4	6	0	1		40	0
17	Hal Kelleher H. Kelleher	12	5/5/1938	PHN	@	CHC		0	108.00	1	0	0	0	1.0	10	12	0	3	0	1		16	0
18	Roxie Lawson R. Lawson	12	7/14/1931	CLE	@	NYY		0	27.00	3	0	0	0	4.0	12	13	2	7	0	1		31	0
19	June Greene J. Greene	12	6/5/1929	PHN	@	CIN		0	54.00	1	0	0	0	2.0	10	12	0	2	0	0		19	0
20	Ryan Weber R. Weber	11	6/13/2021	BOS	vs	TOR		0	17.47	7	0	0	0	5.2	13	11	4	2	0	0	0	30	0
21	Austin Bibens-Dirkx A. Bibens-Dirkx	11	7/21/2018	TEX	vs	CLE		0	24.75	0	0	0	0	4.0	13	11	3	1	1	0	0	27	0
22	Mel Rojas M. Rojas	11	4/29/1999	DET	@	SEA		0	59.40	1	0	0	0	1.2	8	11	3	1	2	0	0	16	0
23	Rich Thompson R. Thompson	11	8/29/1985	CLE	vs	BOS		0	29.70	3	0	0	0	3.1	10	11	2	4	0	0	0	24	2
24	Ray Shore R. Shore	11	6/24/1949	SLA	@	BSA		0	22.85	3	0	0	0	4.1	11	11	1	8	0	1		32	0
25	Tommy Warren T. Warren	11	4/30/1944	BKN	@	NYG		0	19.80	2	0	0	0	5.0	13	15	2	6	0	1		35	1