Andrew McCutchen has the most career games by an active player, with 2,224 games.

Interpreted as:

most regular-season games played by active MLB player

	NAME	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Andrew McCutchen A. McCutchen	2,224	8,227	1,276	2,239	444	50	330	1,134	1,156	94	1,863	220	90	9,555	3,773	824	3	75	70	141	.272	.365	.459	.824	1424	314.2	.357	126	291.6
2	Carlos Santana C. Santana	2,183	7,761	1,102	1,872	401	17	335	1,128	1,325	43	1,526	64	18	9,195	3,312	753	0	66	66	188	.241	.352	.427	.779	1255	181.7	.340	114	156.5
3	Freddie Freeman F. Freeman	2,130	7,926	1,351	2,378	536	32	355	1,291	1,050	111	1,732	100	32	9,151	4,043	923	0	64	140	168	.300	.387	.510	.897	1564	495.3	.381	142	463.2
4	Paul Goldschmidt P. Goldschmidt	2,032	7,493	1,263	2,160	470	24	370	1,225	1,081	51	1,956	174	36	8,681	3,788	864	0	56	121	173	.288	.379	.506	.885	1449	432.1	.376	137	387.6
5	Jose Altuve J. Altuve	1,929	7,707	1,215	2,348	448	32	247	869	639	78	1,104	321	96	8,502	3,601	727	26	52	49	208	.305	.362	.467	.829	1281	290.5	.357	129	295.4
6	Manny Machado M. Machado	1,846	7,237	1,055	2,029	390	18	362	1,121	647	30	1,383	109	40	7,992	3,541	770	14	64	70	221	.280	.339	.489	.828	1175	236.5	.351	124	229.7
7	Nolan Arenado N. Arenado	1,776	6,767	987	1,911	402	34	351	1,175	577	43	1,084	30	23	7,470	3,434	787	5	78	80	199	.282	.339	.507	.847	1131	253	.356	116	149.1
8	Bryce Harper B. Harper	1,735	6,242	1,132	1,753	393	24	352	1,023	1,084	50	1,606	150	50	7,448	3,250	769	13	59	134	137	.281	.388	.521	.909	1292	418.1	.384	142	380.6
9	Justin Turner J. Turner	1,735	5,668	808	1,607	352	9	200	827	586	136	999	47	13	6,458	2,577	561	5	63	18	145	.284	.361	.455	.816	959	198.7	.353	125	196.8
10	Giancarlo Stanton G. Stanton	1,683	6,144	923	1,583	308	11	438	1,129	787	54	2,005	42	15	7,024	3,227	757	0	39	89	154	.258	.345	.525	.870	1114	300.4	.368	135	294.4
11	Salvador Perez S. Perez	1,658	6,290	691	1,676	312	11	293	982	262	90	1,266	6	1	6,695	2,889	616	0	53	42	193	.266	.303	.459	.762	833	54.8	.324	103	24
12	Nick Castellanos N. Castellanos	1,649	6,279	808	1,716	395	42	248	908	423	53	1,577	42	22	6,805	2,939	685	0	50	19	140	.273	.322	.468	.790	925	121.8	.337	111	93.9
13	Xander Bogaerts X. Bogaerts	1,639	6,252	932	1,799	378	18	193	822	589	55	1,244	122	23	6,962	2,792	589	6	60	23	158	.288	.351	.447	.798	987	166	.344	115	130.4
14	Marcus Semien M. Semien	1,613	6,306	960	1,600	321	36	251	794	626	26	1,296	139	40	7,005	2,746	608	7	40	8	100	.254	.322	.435	.757	897	67.7	.326	108	70.8
15	Mike Trout M. Trout	1,601	5,803	1,166	1,717	318	55	397	1,001	1,036	105	1,589	214	38	7,004	3,336	770	0	60	128	73	.296	.408	.575	.983	1366	552.8	.412	167	554.4
16	Eugenio Suárez E. Suárez	1,580	5,632	806	1,398	254	15	312	918	615	102	1,740	33	19	6,420	2,618	581	9	62	15	126	.248	.330	.465	.795	894	132.1	.340	113	104
17	Christian Yelich C. Yelich	1,570	5,931	1,004	1,693	318	35	225	820	812	50	1,502	220	41	6,825	2,756	578	5	27	57	121	.285	.375	.465	.839	1064	261.8	.362	129	244.9
18	Marcell Ozuna M. Ozuna	1,569	5,902	805	1,594	272	21	290	928	582	25	1,441	29	14	6,544	2,778	583	1	34	20	149	.270	.336	.471	.807	937	167.7	.346	119	155.9
19	José Ramírez J. Ramírez	1,558	5,780	968	1,621	385	42	277	923	645	43	775	275	62	6,544	2,921	704	19	57	104	81	.280	.354	.505	.859	1021	245.1	.361	130	237.2
20	Starling Marte S. Marte	1,495	5,635	863	1,610	287	55	158	654	336	165	1,235	359	100	6,183	2,481	500	22	25	18	117	.286	.343	.440	.783	844	121.9	.339	116	116.5
21	Francisco Lindor F. Lindor	1,484	5,885	964	1,603	325	26	268	833	558	75	1,083	202	47	6,611	2,784	619	31	62	36	105	.272	.340	.473	.813	953	165.9	.346	120	157.1
22	Mookie Betts M. Betts	1,482	5,890	1,134	1,708	386	40	282	878	716	51	906	195	40	6,717	3,020	708	4	56	35	78	.290	.369	.513	.881	1122	324.7	.374	136	297
23	George Springer G. Springer	1,406	5,401	942	1,426	240	23	279	769	658	80	1,280	114	40	6,175	2,549	542	2	34	12	117	.264	.351	.472	.823	927	196.6	.354	128	206.5
24	J.T. Realmuto	1,330	4,897	679	1,331	273	35	175	664	354	75	1,138	102	27	5,362	2,199	483	1	35	20	105	.272	.328	.449	.777	714	75.6	.333	110	63.9
25	Joc Pederson J. Pederson	1,324	3,826	589	905	186	18	211	555	518	88	1,053	30	27	4,463	1,760	415	6	25	27	68	.237	.339	.460	.799	630	100.3	.343	118	96