Ty Cobb has gotten the most career hits versus the Red Sox, with 615 hits.

Interpreted as:

most hits by a player against red sox

	NAME	H	G	AB	R	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Ty Cobb T. Cobb	615	437	1,657	316	97	53	13		175	17		139		1,891	857	163	42				.371	.436	.517	.954
2	Eddie Collins E. Collins	493	407	1,458	242	69	25	6		191	14		96		1,730	630	100	67				.338	.420	.432	.852
3	Sam Rice S. Rice	423	340	1,302	215	69	28	2		112	6	34	54		1,450	554	99	30				.325	.381	.425	.806
4	Goose Goslin G. Goslin	406	319	1,206	218	73	22	28	230	129	10	59	31		1,367	607	123	22				.337	.405	.503	.909
5	Lou Gehrig L. Gehrig	404	312	1,149	280	82	22	70	317	211	9	113	21		1,388	740	174	19			2	.352	.456	.644	1.100
6	Al Kaline A. Kaline	403	349	1,300	220	78	7	62	220	151	9	136	17	8	1,471	681	147	7	4	19	28	.310	.385	.524	.908
7	Luke Appling L. Appling	399	336	1,264	173	68	13	5	156	158	2	75	22		1,435	508	86	11			21	.316	.393	.402	.794
8	Charlie Gehringer C. Gehringer	390	339	1,307	265	72	19	19	197	167	6	45	36		1,506	557	110	26			3	.298	.380	.426	.807
9	Al Simmons A. Simmons	383	294	1,158	220	80	23	40	254	88	3	86	22		1,264	629	143	15			2	.331	.380	.543	.923
10	Sam Crawford S. Crawford	349	298	1,148	159	53	37	12		82	2		41		1,265	512	102	33				.304	.351	.446	.797
11	Nellie Fox N. Fox	348	301	1,178	180	52	9	3	113	104	28	21	13	6	1,345	427	64	27	8	2	17	.295	.364	.362	.727
12	Babe Ruth B. Ruth	347	293	1,030	285	61	13	90	272	240	4	139	22		1,290	704	164	16				.337	.464	.683	1.147
13	Derek Jeter D. Jeter	343	283	1,178	176	41	3	26	138	99	24	187	55	10	1,312	468	70	7	4	3	31	.291	.357	.397	.754
14	Nap Lajoie N. Lajoie	342	275	1,051	152	75	21	8		43	11		33		1,134	483	104	29				.325	.358	.460	.818
15	Brooks Robinson B. Robinson	341	336	1,281	148	61	12	37	168	87	4	145	4	3	1,390	537	110	9	9	4	32	.266	.313	.419	.732
16	Harry Heilmann H. Heilmann	336	280	995	167	74	16	26	208	123	8	64	15		1,164	520	116	38				.338	.415	.523	.937
17	Heinie Manush H. Manush	332	259	991	158	63	19	8	144	75	19	36	24		1,112	457	90	27				.335	.393	.461	.854
18	Joe DiMaggio J. DiMaggio	323	253	967	193	58	15	46	222	131	2	63	4	0	1,103	549	119	3			18	.334	.415	.568	.982
19	George Sisler G. Sisler	321	243	950	150	61	20	12		62	9	36	56		1,055	458	93	34				.338	.384	.482	.866
20	Joe Sewell J. Sewell	320	264	988	164	70	10	3	139	123	15	8	18		1,162	419	83	36				.324	.407	.424	.831
21	Clyde Milan C. Milan	313	287	1,062	149	36	22	2		100	10		62		1,195	399	60	23				.295	.361	.376	.737
22	Jimmy Dykes J. Dykes	309	321	1,091	154	75	5	11	134	142	18	115	11		1,292	427	91	41				.283	.375	.391	.766
23	Tristram Speaker T. Speaker	305	244	878	159	90	17	9		122	12	19	23		1,048	456	116	36				.347	.434	.519	.953
24	Joe Kuhel J. Kuhel	301	301	1,125	168	57	14	13	134	168	6	85	28		1,306	425	84	7			7	.268	.366	.378	.743
25	Yogi Berra Y. Berra	297	296	1,097	147	46	9	38	185	87	4	66	3	5	1,189	475	93	1	0	7	25	.271	.327	.433	.760

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StatMuse has game-level data for hits going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Thu 3/26	DET	@	SDP	4:10 PM
Fri 3/27	DET	@	SDP	9:40 PM
Sat 3/28	DET	@	SDP	8:40 PM
Mon 3/30	DET	@	AZ	10:10 PM
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Tue 9/16	CIN	@	STL	6-2
Tue 9/16	ATL	@	WSH	9-4
Tue 9/16	ATH	@	BOS	4-5
Tue 9/16	TOR	@	TBR	1-2
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DATE	MATCHUP			TIME (ET)
Wed 3/25	NYY	@	SFG	8:05 PM
Thu 3/26	PIT	@	NYM	1:15 PM
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Ty Cobb has gotten the most career hits versus the Red Sox, with 615 hits.

Interpreted as:

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