Ty Cobb has gotten the most career hits against the White Sox, with 575 hits.

Interpreted as:

most hits by a player against whitesox

	NAME	H	G	AB	R	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Ty Cobb T. Cobb	575	427	1,621	301	96	30	11		177	13		108		1,853	764	137	42				.355	.422	.471	.894
2	Tristram Speaker T. Speaker	511	405	1,477	240	119	32	11		189	10		46		1,712	727	162	36				.346	.424	.492	.916
3	Sam Rice S. Rice	430	341	1,334	205	55	23	4		99	5	44	48		1,469	543	82	31				.322	.371	.407	.778
4	Lou Gehrig L. Gehrig	405	303	1,158	280	84	22	77	300	198	4	84	17		1,381	764	183	21				.350	.446	.660	1.106
5	Babe Ruth B. Ruth	404	354	1,188	303	74	18	98	331	287	4	173	16		1,491	808	190	12				.340	.470	.680	1.150
6	Goose Goslin G. Goslin	394	321	1,227	209	74	22	36	233	132	6	68	25		1,391	620	132	26				.321	.390	.505	.895
7	Charlie Gehringer C. Gehringer	385	322	1,232	242	75	24	27	196	152	7	54	31		1,417	589	126	26			4	.313	.391	.478	.869
8	Heinie Manush H. Manush	368	281	1,076	198	67	30	17	182	60	9	40	16		1,176	546	114	31				.342	.382	.507	.889
9	Ted Williams T. Williams	364	330	1,125	226	63	12	65	244	256	4	101	2	0	1,388	646	140	0	3	19	30	.324	.450	.574	1.024
10	Jimmie Foxx J. Foxx	362	309	1,090	240	57	20	75	267	220	2	159	10		1,320	684	152	8			9	.332	.445	.628	1.073
11	Al Kaline A. Kaline	361	321	1,187	168	50	8	38	154	131	6	101	21	8	1,343	541	96	8	11	17	36	.304	.373	.456	.829
12	Doc Cramer D. Cramer	361	291	1,176	186	56	11	4	95	83	6	30	13		1,284	451	71	19			13	.307	.356	.384	.739
13	Harry Heilmann H. Heilmann	360	277	1,037	162	74	18	20		102	3	61	14		1,178	530	112	36				.347	.407	.511	.918
14	Nap Lajoie N. Lajoie	358	283	1,056	151	71	11	6		69	10		43		1,164	469	88	29				.339	.385	.444	.829
15	Sam Crawford S. Crawford	351	298	1,137	130	68	43	5		87	2		35		1,253	520	116	27				.309	.359	.457	.816
16	Al Simmons A. Simmons	346	253	1,028	188	53	21	37	243	60	2	57	6		1,101	552	111	11			4	.337	.374	.537	.911
17	Joe Judge J. Judge	345	297	1,117	169	59	20	3	130	126	3	61	31		1,279	453	82	33				.309	.380	.406	.786
18	George Sisler G. Sisler	335	219	883	155	44	20	12		46	5	42	41		959	455	76	25				.379	.413	.515	.929
19	Mickey Vernon M. Vernon	334	334	1,245	148	67	14	19	147	101	6	116	24	1	1,364	486	100	11	1	2	21	.268	.326	.390	.716
20	Joe Sewell J. Sewell	330	278	1,050	161	72	8	5	138	123	7	18	9		1,231	433	85	51				.314	.390	.412	.802
21	Mickey Mantle M. Mantle	329	322	1,121	210	54	10	72	192	206	0	231	23	6	1,333	619	136	3	3	23	22	.293	.402	.552	.954
22	Bobby Doerr B. Doerr	314	264	1,024	155	54	14	34	167	101	3	75	12	0	1,144	498	102	16			20	.307	.371	.486	.857
23	Joe Cronin J. Cronin	308	305	1,070	173	60	9	26	186	146	8	101	17		1,254	464	95	30			6	.288	.377	.434	.811
24	Brooks Robinson B. Robinson	304	306	1,138	116	50	6	29	133	80	9	115	5	5	1,257	453	85	14	16	13	31	.267	.316	.398	.714
25	Joe DiMaggio J. DiMaggio	303	236	935	192	42	25	58	203	96	5	44	5	0	1,037	569	125	1			19	.324	.390	.609	.999

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StatMuse has game-level data for hits going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Thu 3/26	DET	@	SDP	4:10 PM
Fri 3/27	DET	@	SDP	9:40 PM
Sat 3/28	DET	@	SDP	8:40 PM
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Tue 9/16	TOR	@	TBR	1-2
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Wed 3/25	NYY	@	SFG	8:05 PM
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Ty Cobb has gotten the most career hits against the White Sox, with 575 hits.

Interpreted as:

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