Since 2000, Mark Buehrle has given up the most hits, with 3,472 hits.

	NAME	H	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Mark Buehrle M. Buehrle	3,472	518	214	160	.572	493	3.81	1,870	33	10	0	3283.1	1,391	1,542	361	734	79	6	49	13,705	27	5.13	2.01	2.55	0.99	13.6	5.4	1.28	.292	4.23	87	4.11	93	9.52	111.9
2	CC Sabathia	3,404	561	251	161	.609	560	3.74	3,093	38	12	0	3577.1	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
3	Zack Greinke Z. Greinke	3,207	586	225	156	.591	541	3.49	2,979	17	5	1	3389.1	1,315	1,410	367	762	79	8	25	13,877	101	7.91	2.02	3.91	0.97	21.5	5.5	1.17	.293	3.74	83	3.51	85	8.52	235
4	Bartolo Colon B. Colon	3,096	483	211	167	.558	472	4.11	2,150	30	10	0	2958.2	1,351	1,465	388	748	51	2	36	12,487	32	6.54	2.28	2.87	1.18	17.2	6.0	1.30	.296	4.46	96	4.14	97	9.42	44.8
5	Livan Hernandez L. Hernandez	2,949	438	151	150	.502	394	4.45	1,596	39	9	1	2655.2	1,312	1,404	297	846	67	17	72	11,472	35	5.41	2.87	1.89	1.01	13.9	7.4	1.43	.306	4.76	105	4.35	102	9.99	-29.4
6	Justin Verlander J. Verlander	2,931	534	262	149	.637	534	3.31	3,451	26	9	0	3457.2	1,273	1,377	361	967	116	0	27	14,123	97	8.98	2.52	3.57	0.94	24.4	6.8	1.13	.279	3.58	78	3.43	81	7.63	306
7	John Lackey J. Lackey	2,862	448	188	147	.561	446	3.92	2,294	18	8	0	2840.1	1,237	1,347	319	815	133	0	32	12,030	125	7.27	2.58	2.81	1.01	19.1	6.8	1.29	.300	4.27	92	3.94	94	9.07	79.6
8	Tim Hudson T. Hudson	2,836	461	211	131	.617	458	3.50	1,948	25	13	0	2990.1	1,164	1,263	240	855	120	0	82	12,425	78	5.86	2.57	2.28	0.72	15.7	6.9	1.23	.280	3.80	84	3.79	91	8.54	131.3
9	Kyle Lohse K. Lohse	2,711	457	147	143	.507	418	4.40	1,615	12	9	2	2531.2	1,239	1,327	316	694	87	15	34	10,839	57	5.74	2.47	2.33	1.12	14.9	6.4	1.34	.295	4.72	105	4.35	105	9.64	-58.3
10	Jon Lester J. Lester	2,610	452	200	117	.631	451	3.66	2,488	15	4	0	2740.0	1,114	1,215	294	892	90	0	13	11,487	63	8.17	2.93	2.79	0.97	21.7	7.8	1.28	.300	3.99	86	3.77	92	8.57	101.7
11	James Shields J. Shields	2,581	407	145	139	.511	405	4.01	2,234	23	9	0	2616.0	1,167	1,267	361	746	97	1	22	10,993	107	7.69	2.57	2.99	1.24	20.3	6.8	1.27	.294	4.36	98	4.16	101	8.88	-13.5
12	Adam Wainwright A. Wainwright	2,577	478	200	128	.610	411	3.53	2,202	28	11	3	2668.1	1,047	1,117	233	736	81	13	40	11,116	51	7.43	2.48	2.99	0.79	19.8	6.6	1.24	.298	3.77	88	3.53	87	8.69	152.8
13	Bronson Arroyo B. Arroyo	2,507	419	148	137	.519	383	4.28	1,571	16	6	1	2435.2	1,158	1,260	347	661	105	6	60	10,338	42	5.80	2.44	2.38	1.28	15.2	6.4	1.30	.282	4.66	100	4.59	108	9.26	-82
14	Felix Hernandez F. Hernandez	2,487	419	169	136	.554	418	3.42	2,524	25	11	0	2729.2	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
15	A.J. Burnett	2,482	428	160	155	.508	423	3.99	2,480	24	10	0	2690.0	1,194	1,305	260	1,075	143	1	33	11,483	161	8.30	3.60	2.31	0.87	21.6	9.4	1.32	.295	4.37	97	3.85	92	8.30	96.2
16	Roy Halladay R. Halladay	2,481	378	194	98	.664	370	3.36	2,022	65	19	0	2586.0	966	1,055	215	511	77	4	27	10,566	50	7.04	1.78	3.96	0.75	19.1	4.8	1.16	.293	3.67	77	3.27	75	8.63	304.7
17	Derek Lowe D. Lowe	2,475	524	165	139	.543	358	4.03	1,513	10	4	67	2370.0	1,061	1,184	194	704	66	127	58	10,097	44	5.75	2.67	2.15	0.74	15.0	7.0	1.34	.299	4.50	94	3.83	90	9.40	111.4
18	Aaron Harang A. Harang	2,445	387	128	143	.472	381	4.26	1,842	15	8	0	2322.0	1,099	1,177	298	712	63	2	54	9,975	76	7.14	2.76	2.59	1.16	18.5	7.1	1.36	.304	4.56	103	4.17	100	9.48	12.3
19	Javier Vazquez J. Vazquez	2,434	391	151	137	.524	385	4.04	2,284	25	7	0	2513.0	1,129	1,212	322	643	73	4	52	10,504	72	8.18	2.30	3.55	1.15	21.7	6.1	1.22	.294	4.34	91	3.77	86	8.72	179
20	Cole Hamels C. Hamels	2,424	423	163	122	.572	422	3.43	2,560	17	7	0	2698.0	1,027	1,103	310	767	100	0	43	11,115	57	8.54	2.56	3.34	1.03	23.0	6.9	1.18	.287	3.68	82	3.68	88	8.09	151.3
21	Ervin Santana E. Santana	2,391	425	151	129	.539	386	4.11	1,978	21	11	0	2486.2	1,135	1,221	331	776	104	20	35	10,482	104	7.16	2.81	2.55	1.20	18.9	7.4	1.27	.282	4.42	99	4.31	104	8.65	-44.1
22	Barry Zito B. Zito	2,381	433	165	143	.536	421	4.04	1,885	12	5	0	2576.2	1,157	1,254	282	1,064	97	9	52	11,001	50	6.58	3.72	1.77	0.98	17.1	9.7	1.34	.274	4.38	97	4.38	104	8.32	-43.1
23	Kevin Millwood K. Millwood	2,372	375	129	134	.490	373	4.26	1,673	17	5	0	2266.2	1,073	1,165	253	707	65	0	40	9,735	55	6.64	2.81	2.37	1.00	17.2	7.3	1.36	.301	4.63	97	4.07	93	9.42	78.1
24	Andy Pettitte A. Pettitte	2,361	366	175	107	.621	363	3.82	1,739	12	3	0	2271.2	963	1,080	203	655	39	1	33	9,631	40	6.89	2.60	2.65	0.80	18.1	6.8	1.33	.309	4.28	86	3.63	82	9.35	201.4
25	Dan Haren D. Haren	2,357	391	153	131	.539	380	3.75	2,013	16	6	1	2419.2	1,009	1,105	305	500	67	4	39	10,022	98	7.49	1.86	4.03	1.13	20.1	5.0	1.18	.288	4.11	92	3.77	92	8.77	92.8