17 players are tied for the most homers in a game, with 4 homers. The first three are Eugenio Suárez on April 26, J.D. Martinez on September 4, 2017 and Scooter Gennett on June 6, 2017.

Interpreted as:

most home runs by a player in a regular-season game all-time

	NAME	HR	DATE	TM		OPP	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Eugenio Suárez E. Suárez	4	4/26/2025	AZ	vs	ATL	4	4	4	0	0	5	0	0	0	0	0	4	16	4	0	0	0	0
2	J.D. Martinez	4	9/4/2017	ARI	@	LAD	5	4	4	0	0	6	0	0	1	0	0	5	16	4	0	0	0	0
3	Scooter Gennett S. Gennett	4	6/6/2017	CIN	vs	STL	5	4	5	0	0	10	0	0	0	0	0	5	17	4	0	0	0	0
4	Josh Hamilton J. Hamilton	4	5/8/2012	TEX	@	BAL	5	4	5	1	0	8	0	0	0	0	0	5	18	5	0	0	0	0
5	Carlos Delgado C. Delgado	4	9/25/2003	TOR	vs	TBD	4	4	4	0	0	6	0	0	0	0	0	4	16	4	0	0	0	0
6	Shawn Green S. Green	4	5/23/2002	LAD	@	MIL	6	6	6	1	0	7	0	0	0	0	0	6	19	5	0	0	0	0
7	Mike Cameron M. Cameron	4	5/2/2002	SEA	@	CWS	5	4	4	0	0	4	0	1	0	0	0	6	16	4	0	0	0	0
8	Mark Whiten M. Whiten	4	9/7/1993	STL	@	CIN	5	4	4	0	0	12	0	0	0	0	0	5	16	4	0	0	0	0
9	Bob Horner B. Horner	4	7/6/1986	ATL	vs	MON	5	4	4	0	0	6	0	0	0	0	0	5	16	4	0	0	0	0
10	Mike Schmidt M. Schmidt	4	4/17/1976	PHI	@	CHC	6	4	5	0	0	8	0	0	0	0	0	6	17	4	0	0	0	0
11	Willie Mays W. Mays	4	4/30/1961	SFG	@	MIL	5	4	4	0	0	8	0	0	0	0	0	5	16	4	0	0	0	0
12	Rocky Colavito R. Colavito	4	6/10/1959	CLE	@	BAL	4	5	4	0	0	6	1	0	0	0	0	5	16	4	0	0	0	0
13	Joe Adcock J. Adcock	4	7/31/1954	MIL	@	BKN	5	5	5	1	0	7	0	0	0	0	0	5	18	5	0	0	0	0
14	Gil Hodges G. Hodges	4	8/31/1950	BKN	vs	BSN	6	5	5	0	0	9	0	0	0	0	0	6	17	4	0		0	0
15	Pat Seerey P. Seerey	4	7/18/1948	CWS	@	PHA	6	4	4	0	0	7	1	0	1	0	0	7	16	4	0			0
16	Chuck Klein C. Klein	4	7/10/1936	PHN	@	PIT	5	4	4	0	0	6	0	0	0	0	0	5	16	4	0			0
17	Lou Gehrig L. Gehrig	4	6/3/1932	NYY	@	PHA	6	4	4	0	0	6	0	0	0	0	0	6	16	4	0
18	Kerry Carpenter K. Carpenter	3	6/2/2025	DET	@	CWS	5	3	3	0	0	5	0	0	1	0	0	5	12	3	0	0	0	0
19	Wilmer Flores W. Flores	3	5/16/2025	SFG	vs	ATH	5	3	3	0	0	8	0	0	0	0	0	5	12	3	0	0	0	0
20	Jasson Domínguez J. Domínguez	3	5/9/2025	NYY	@	ATH	4	3	3	0	0	7	0	0	1	0	0	5	12	3	0	1	0	0
21	José Ramírez J. Ramírez	3	4/4/2025	CLE	@	LAA	4	3	3	0	0	4	1	0	1	0	0	5	12	3	0	0	0	0
22	Iván Herrera I. Herrera	3	4/2/2025	STL	vs	LAA	4	3	3	0	0	6	1	0	1	0	0	5	12	3	0	0	0	0
23	Aaron Judge A. Judge	3	3/29/2025	NYY	vs	MIL	6	4	4	1	0	8	0	0	0	0	0	6	14	4	0	0	0	0
24	Triston Casas T. Casas	3	9/22/2024	BOS	vs	MIN	4	3	3	0	0	7	0	0	0	0	0	4	12	3	0	0	0	0
25	Shohei Ohtani S. Ohtani	3	9/19/2024	LAD	@	MIA	6	4	6	2	0	10	0	0	0	2	0	6	17	5	0	0	0	0