13 players were tied for the most homers in a game in 2021, with 3 homers. The first three are Brandon Lowe on October 2, 2021, Francisco Lindor on September 12, 2021 and Rafael Ortega on August 1, 2021.

Interpreted as:

most homerun by a player hit in a regular-season game in 2021

	NAME	HR	DATE	TM		OPP	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Brandon Lowe B. Lowe	3	10/2/2021	TBR	@	NYY	5	3	3	0	0	7	0	0	1	0	0	5	12	3	0	0	0	0
2	Francisco Lindor F. Lindor	3	9/12/2021	NYM	vs	NYY	4	3	3	0	0	5	1	0	0	0	0	5	12	3	0	0	0	0
3	Rafael Ortega R. Ortega	3	8/1/2021	CHC	@	WSH	4	3	4	0	0	5	0	0	0	0	1	4	13	3	0	0	0	0
4	Seby Zavala S. Zavala	3	7/31/2021	CWS	vs	CLE	4	4	4	0	0	6	0	0	0	0	0	4	13	3	0	0	0	0
5	Brad Miller B. Miller	3	7/8/2021	PHI	@	CHC	5	3	3	0	0	5	0	0	0	0	0	5	12	3	0	0	0	0
6	Fernando Tatis Jr. F. Tatis Jr.	3	6/25/2021	SDP	vs	ARI	5	4	4	0	0	4	0	0	0	0	0	5	13	3	0	0	0	0
7	Kyle Schwarber K. Schwarber	3	6/20/2021	WSH	vs	NYM	4	3	3	0	0	4	0	0	0	0	0	4	12	3	0	0	0	0
8	Ryan Mountcastle R. Mountcastle	3	6/19/2021	BAL	vs	TOR	4	3	4	0	0	4	0	0	0	0	0	4	13	3	0	0	0	0
9	Jesse Winker J. Winker	3	6/6/2021	CIN	@	STL	4	3	3	0	0	6	1	0	0	0	0	5	12	3	0	0	0	0
10	Jesse Winker J. Winker	3	5/21/2021	CIN	vs	MIL	4	4	4	0	0	3	1	0	0	0	0	5	13	3	0	0	0	0
11	Miguel Sanó M. Sanó	3	5/18/2021	MIN	vs	CWS	4	3	3	0	0	4	0	0	0	0	0	4	12	3	0	0	0	0
12	Vladimir Guerrero Jr. V. Guerrero Jr.	3	4/27/2021	TOR	vs	WSH	4	3	3	0	0	7	0	0	0	0	0	4	12	3	0	0	0	1
13	J.D. Martinez	3	4/11/2021	BOS	@	BAL	6	4	4	0	0	4	0	0	2	0	0	6	13	3	0	0	0	0
14	Ryan McMahon R. McMahon	3	4/6/2021	COL	vs	ARI	6	3	4	1	0	4	0	0	0	0	0	6	14	4	0	0	0	0
15	Seth Brown S. Brown	2	10/3/2021	OAK	@	HOU	4	2	2	0	0	3	0	0	0	0	0	4	8	2	0	0	0	0
16	George Springer G. Springer	2	10/3/2021	TOR	vs	BAL	4	3	3	0	0	5	1	0	1	0	0	5	9	2	0	0	0	0
17	Rafael Devers R. Devers	2	10/3/2021	BOS	@	WSH	5	3	4	0	0	4	0	0	1	0	0	5	10	2	0	0	0	0
18	Brandon Nimmo B. Nimmo	2	10/1/2021	NYM	@	ATL	4	2	2	0	0	2	0	0	2	0	0	4	8	2	0	0	0	0
19	Tyler O'Neill T. O'Neill	2	10/1/2021	STL	vs	CHC	4	3	3	1	0	2	0	0	0	1	0	4	10	3	0	0	0	0
20	Trea Turner T. Turner	2	10/1/2021	LAD	vs	MIL	3	2	2	0	0	5	1	0	0	0	0	4	8	2	0	0	1	0
21	Dylan Carlson D. Carlson	2	9/30/2021	STL	vs	MIL	3	2	2	0	0	3	1	0	1	0	0	4	8	2	0	0	0	0
22	Aaron Judge A. Judge	2	9/30/2021	NYY	@	TOR	3	2	2	0	0	2	1	0	0	0	0	4	8	2	0	0	0	0
23	Pete Alonso P. Alonso	2	9/30/2021	NYM	vs	MIA	5	2	2	0	0	3	0	0	1	0	0	5	8	2	0	0	0	0
24	Byron Buxton B. Buxton	2	9/30/2021	MIN	vs	DET	5	3	3	1	0	2	0	0	0	0	0	5	10	3	0	0	0	0
25	Niko Goodrum N. Goodrum	2	9/30/2021	DET	@	MIN	3	2	2	0	0	4	0	1	0	0	0	4	8	2	0	0	0	0