Marcus Semien has hit the most homers by a second baseman in a season, with 45 homers in 2021.

most homeruns in a season by second baseman
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2021Semien1973Johnson2016Dozier1922Hornsby1990Sandberg2021Lowe2018Ramirez2016Cano2002Soriano1929Hornsby1925Hornsby2019Torres2003Soriano1999Bell2002Kent2001Boone2011Uggla2009Hill2005Soriano2019Escobar2019Muncy2003Boone45434242403939393939393838383737363636353535
NAMESEASONTMGHRABRH2B3BRBISHSFSBCSBBIBBHBPSOGIDPPATBXBHAVGOBPSLGOPSWRCWRC+WOBAWRAABRAA
Marcus SemienMarcus Semien2021
TORTOR
16245652115173392102031516603146972435186.265.334.538.873120132.36831.928.2
Davey JohnsonDavey Johnson1973
ATLATL
1574355984151250990253819993865130568.270.370.546.916114146.40442.134.7
Brian DozierBrian Dozier2016
MINMIN
15542615104165355992518261681381269133682.268.340.546.886111132.37029.526.3
Rogers HornsbyRogers Hornsby1922
SLNSLN
15442623141250461415215171265150704450102.401.459.7221.181186197.52097.892.7
Ryne SandbergRyne Sandberg1990
CHCCHC
1554061511618830310009257508184867534473.306.354.559.913116142.39640.333.3
Brandon LoweBrandon Lowe2021
TBRTBR
14939535971323109903716849167261528070.247.340.523.86399136.36324.927
Jose RamirezJose Ramirez2018
CLECLE
157395781101563841050634610615880269831981.270.387.552.939125146.39143.738.6
Robinson CanoRobinson Cano2016
SEASEA
16139655107195332103050147881001871534974.298.350.533.882115139.37030.733.3
Alfonso SorianoAlfonso Soriano2002
NYYNYY
1563969612820951210217411323114157874138192.300.332.547.880118131.37429.227.9
Rogers HornsbyRogers Hornsby1929
CHCCHC
156396021562294781492228716571240994.380.459.6791.139181174.49786.877.3
Rogers HornsbyRogers Hornsby1925
SLNSLN
13839504133203411014316538323960538190.403.489.7561.245173208.54094.190.1
Gleyber TorresGleyber Torres2019
NYYNYY
144385469615226090165248331291060429264.278.337.535.87196124.35820.118.9
Alfonso SorianoAlfonso Soriano2003
NYYNYY
15638682114198365910235838712130873435879.290.338.525.863113124.36523.122.1
Jay BellJay Bell1999
ARIARI
1513858913217032611249748224132968832876.289.374.557.931122129.39532.326.8
Jeff KentJeff Kent2002
SFGSFG
15237623102195422108035152341012068235281.313.368.565.933122147.39740.240.1
Bret BooneBret Boone2001
SEASEA
158376231182063731415135540591101169036077.331.372.578.950126149.39740.542.5
Dan UgglaDan Uggla2011
ATLATL
16136600881402218203136227156967227259.233.311.453.76485110.3349.48
Aaron HillAaron Hill2009
TORTOR
1583668210319537010814624215981773434073.286.330.499.829105115.35717.113.4
Alfonso SorianoAlfonso Soriano2005
TEXTEX
15636637102171432104053023337125668232681.268.309.512.82194108.34712.26.6
Eduardo EscobarEduardo Escobar2019
ARIARI
15835636941712910118010515033130869932574.269.320.511.831101109.34112.88.5
Max MuncyMax Muncy2019
LADLAD
141354871011222219804419018149558925158.251.374.515.889101134.37226.726.1
Bret BooneBret Boone2003
SEASEA
159356221111833551171716368371251770533375.294.366.535.902119140.38432.935.4
Brian DozierBrian Dozier2017
MINMIN
15234617106167304930216778681411170530768.271.359.498.856110126.36224.422.5
Jorge PolancoJorge Polanco2021
MINMIN
152335889715835298061164505118464429670.269.323.503.82697121.34918.616.9
Rougned OdorRougned Odor2016
TEXTEX
150336058916433488041471904135663230470.271.296.502.79884103.3369.31.9