Jeremy Guthrie and Derek Lowe were tied for losing the most games in 2011, with 17 games.

	NAME	L	SEASON	TM	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Jeremy Guthrie J. Guthrie	17	2011	BAL	9	.654	34	.346	32	4.33	130	2	0	0	208.0	213	100	113	26	66	9	1	5	889	0	5.63	2.86	1.97	1.13	14.6	7.4	1.34	.284	4.89	103	4.47	107	9.22	-5.8
2	Derek Lowe D. Lowe	17	2011	ATL	9	.654	34	.346	34	5.05	137	0	0	0	187.0	212	105	110	14	70	3	0	4	830	1	6.59	3.37	1.96	0.67	16.5	8.4	1.51	.327	5.29	134	3.70	98	10.20	1.3
3	Jeff Francis J. Francis	16	2011	KCR	6	.727	31	.273	31	4.82	91	1	0	0	183.0	224	98	102	19	39	5	0	5	803	5	4.48	1.92	2.33	0.93	11.3	4.9	1.44	.316	5.02	116	4.09	102	11.02	-2
4	Hiroki Kuroda H. Kuroda	16	2011	LAD	13	.552	32	.448	32	3.07	161	0	0	0	202.0	196	69	77	24	49	5	0	6	838	12	7.17	2.18	3.29	1.07	19.2	5.8	1.21	.287	3.43	85	3.77	99	8.73	0.7
5	J.A. Happ	15	2011	HOU	6	.714	28	.286	28	5.35	134	0	0	0	156.1	157	93	103	21	83	2	0	5	698	3	7.71	4.78	1.61	1.21	19.2	11.9	1.54	.297	5.93	142	4.68	121	9.04	-13.7
6	Roberto Hernandez R. Hernandez	15	2011	CLE	7	.682	32	.318	32	5.25	109	0	0	0	188.2	205	110	125	22	60	14	0	3	833	3	5.20	2.86	1.82	1.05	13.1	7.2	1.40	.291	5.96	134	4.56	115	9.78	-12.9
7	Trevor Cahill T. Cahill	14	2011	OAK	12	.538	34	.462	34	4.16	147	0	0	0	207.2	214	96	102	19	82	8	0	1	901	15	6.37	3.55	1.79	0.82	16.3	9.1	1.43	.302	4.42	105	4.09	103	9.27	-3.3
8	Jhoulys Chacin J. Chacin	14	2011	COL	11	.560	31	.440	31	3.62	150	2	1	0	194.0	168	78	87	20	87	4	0	1	827	7	6.96	4.04	1.72	0.93	18.1	10.5	1.31	.261	4.04	83	4.22	103	7.79	-1.6
9	Ryan Dempster R. Dempster	14	2011	CHC	10	.583	34	.417	34	4.80	191	0	0	0	202.1	211	108	111	23	82	5	0	2	881	7	8.50	3.65	2.33	1.02	21.7	9.3	1.45	.324	4.94	121	3.90	100	9.39	-0.3
10	Brian Duensing B. Duensing	14	2011	MIN	9	.609	32	.391	28	5.23	115	1	1	0	161.2	193	94	102	21	52	1	0	3	711	3	6.40	2.89	2.21	1.17	16.2	7.3	1.52	.330	5.68	127	4.27	107	10.74	-4.9
11	Felix Hernandez F. Hernandez	14	2011	SEA	14	.500	33	.500	33	3.47	222	5	0	0	233.2	218	90	99	19	67	7	0	0	964	12	8.55	2.58	3.31	0.73	23.0	7.0	1.22	.307	3.81	90	3.13	80	8.40	20.9
12	Mat Latos M. Latos	14	2011	SDP	9	.609	31	.391	31	3.47	185	0	0	0	194.1	168	75	82	16	62	1	0	3	799	5	8.57	2.87	2.98	0.74	23.2	7.8	1.18	.284	3.80	99	3.16	85	7.78	12.5
13	Ted Lilly T. Lilly	14	2011	LAD	12	.538	33	.462	33	3.97	158	0	0	0	192.2	172	85	88	28	51	9	0	8	800	2	7.38	2.38	3.10	1.31	19.8	6.4	1.16	.260	4.11	110	4.20	110	8.03	-8.6
14	Tim Lincecum T. Lincecum	14	2011	SFG	13	.519	33	.481	33	2.74	220	1	1	0	217.0	176	66	74	15	86	6	0	5	900	9	9.12	3.57	2.56	0.62	24.4	9.6	1.21	.281	3.07	76	3.16	86	7.30	12.9
15	Paul Maholm P. Maholm	14	2011	PIT	6	.700	26	.300	26	3.66	97	1	1	0	162.1	160	66	72	11	50	8	0	6	687	3	5.38	2.77	1.94	0.61	14.1	7.3	1.29	.286	3.99	99	3.78	100	8.87	-0.3
16	Brett Myers B. Myers	14	2011	HOU	7	.667	34	.333	33	4.46	160	2	0	0	216.0	226	107	116	31	57	4	1	5	917	7	6.67	2.38	2.81	1.29	17.4	6.2	1.31	.293	4.83	118	4.25	109	9.42	-8.6
17	Madison Bumgarner M. Bumgarner	13	2011	SFG	13	.500	33	.500	33	3.21	191	0	0	0	204.2	202	73	82	12	46	5	0	5	844	0	8.40	2.02	4.15	0.53	22.6	5.5	1.21	.322	3.61	90	2.66	72	8.88	24
18	R.A. Dickey	13	2011	NYM	8	.619	33	.381	32	3.28	134	1	0	0	208.2	202	76	85	18	54	9	0	2	876	9	5.78	2.33	2.48	0.78	15.3	6.2	1.23	.278	3.67	89	3.76	100	8.71	0
19	Doug Fister D. Fister	13	2011	TOT	11	.542	32	.458	31	2.83	146	3	0	0	216.1	193	68	76	11	37	12	0	2	875	3	6.07	1.54	3.95	0.46	16.7	4.2	1.06	.272	3.16	73	3.01	76	8.03	23
20	Gavin Floyd G. Floyd	13	2011	CWS	12	.520	31	.480	30	4.37	151	1	0	0	193.2	180	94	97	22	45	11	1	2	798	12	7.02	2.09	3.36	1.02	18.9	5.6	1.16	.278	4.51	103	3.80	90	8.36	9.4
21	Jason Hammel J. Hammel	13	2011	COL	7	.650	32	.350	27	4.76	94	0	0	1	170.1	175	90	100	21	68	6	2	3	739	8	4.97	3.59	1.38	1.11	12.7	9.2	1.43	.280	5.28	108	4.82	117	9.25	-12.1
22	Livan Hernandez L. Hernandez	13	2011	WSH	8	.619	29	.381	29	4.47	99	1	1	0	175.1	199	87	98	16	46	5	0	6	751	3	5.08	2.36	2.15	0.82	13.2	6.1	1.40	.313	5.03	117	3.95	103	10.21	-2
23	Ubaldo Jimenez U. Jimenez	13	2011	TOT	10	.565	32	.435	32	4.68	180	2	1	0	188.1	186	98	111	17	78	9	0	5	822	8	8.60	3.73	2.31	0.81	21.9	9.5	1.40	.314	5.30	112	3.67	90	8.89	8
24	John Lannan J. Lannan	13	2011	WSH	10	.565	33	.435	33	3.70	106	0	0	0	184.2	194	76	90	15	76	7	0	3	808	4	5.17	3.70	1.39	0.73	13.1	9.4	1.46	.296	4.39	97	4.27	111	9.45	-8.8
25	Carl Pavano C. Pavano	13	2011	MIN	9	.591	33	.409	33	4.30	102	3	1	0	222.0	262	106	123	23	40	8	0	0	955	4	4.14	1.62	2.55	0.93	10.7	4.2	1.36	.306	4.99	104	4.09	102	10.62	-2.5