Lou Gehrig has the most career games when collecting 5+ RBI, with 41 games.

Interpreted as:

most MLB regular-season games by a player getting at least 5 rbis

	NAME	G	RBI	AB	R	H	2B	3B	HR	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Lou Gehrig L. Gehrig	41	231	181	111	120	22	8	59	27	2	8	1		214	335	89	4				.663	.710	1.851	2.560
2	Manny Ramirez M. Ramirez	34	179	133	68	87	13	0	54	20	2	14	0	1	158	262	67	0	3	2	0	.654	.690	1.970	2.660
3	Alex Rodriguez A. Rodriguez	29	167	129	74	86	9	0	50	14	2	9	3	0	150	245	59	1	4	0	2	.667	.685	1.899	2.584
4	Sammy Sosa S. Sosa	29	155	133	59	80	9	1	46	4	0	13	1	0	139	229	56	0	2	0	0	.602	.604	1.722	2.326
5	Juan Gonzalez J. Gonzalez	28	149	124	59	75	12	1	44	9	1	20	1	0	137	221	57	0	3	2	1	.605	.620	1.782	2.403
6	Nelson Cruz N. Cruz	26	148	118	57	76	14	2	44	8	1	19	0	0	127	226	60	0	0	1	1	.644	.669	1.915	2.585
7	Albert Pujols A. Pujols	26	136	110	56	67	13	0	44	5	2	10	0	0	117	212	57	0	0	0	2	.609	.632	1.927	2.560
8	Joe DiMaggio J. DiMaggio	26	149	127	64	83	11	6	42	13	0	1	1	0	141	232	59	1			1	.654	.686	1.827	2.512
9	Jimmie Foxx J. Foxx	26	148	122	63	79	14	4	42	16	0	7	3		138	227	60	0			0	.648	.688	1.861	2.549
10	Babe Ruth B. Ruth	25	140	111	58	72	11	2	45	12	0	9	2		126	222	58	3				.649	.683	2.000	2.683
11	Ted Williams T. Williams	24	137	110	53	66	9	2	37	20	0	8	1	0	130	190	48	0	0	0	2	.600	.662	1.727	2.389
12	Barry Bonds B. Bonds	23	123	99	53	68	9	0	39	8	0	9	1	1	108	194	48	0	1	2	1	.687	.704	1.960	2.663
13	Cecil Fielder C. Fielder	23	123	97	46	59	7	0	42	10	1	11	0	0	112	192	49	0	4	1	2	.608	.625	1.979	2.604
14	Jeff Bagwell J. Bagwell	22	118	101	56	66	9	1	35	9	1	9	1	0	112	182	45	0	1	1	0	.653	.679	1.802	2.481
15	Carlos Delgado C. Delgado	22	117	92	50	55	7	1	41	9	4	12	0	0	109	187	49	0	4	2	0	.598	.624	2.033	2.656
16	Dave Kingman D. Kingman	22	128	102	49	55	3	1	43	6	1	14	0	0	111	189	47	0	2	0	1	.539	.559	1.853	2.411
17	Hank Aaron H. Aaron	22	116	105	45	63	8	1	35	2	1	8	1	1	108	178	44	0	0	1	1	.600	.611	1.695	2.306
18	Jeff Kent J. Kent	21	114	92	42	60	21	1	25	6	0	7	0	1	101	158	47	0	3	0	0	.652	.653	1.717	2.371
19	Gary Sheffield G. Sheffield	21	114	93	42	58	8	1	36	11	0	3	2	2	106	176	45	0	2	1	1	.624	.651	1.892	2.543
20	Mel Ott M. Ott	21	115	96	49	58	10	2	34	10	1	7	1		108	174	46	1			0	.604	.645	1.813	2.457
21	Al Simmons A. Simmons	21	116	113	46	69	10	4	27	1	1	10	1		116	168	41	1				.611	.617	1.487	2.104
22	Miguel Cabrera M. Cabrera	19	101	87	42	61	12	0	25	5	0	6	1	0	94	148	37	0	2	3	1	.701	.702	1.701	2.403
23	Adam Dunn A. Dunn	19	97	73	36	47	5	0	32	8	0	13	1	0	84	148	37	0	3	2	1	.644	.655	2.027	2.682
24	Frank Thomas F. Thomas	19	97	81	39	47	13	0	25	8	0	12	0	0	92	135	38	0	3	1	1	.580	.598	1.667	2.264
25	Ruben Sierra R. Sierra	19	99	86	32	49	11	0	21	6	0	9	2	1	95	123	32	0	3	1	1	.570	.579	1.430	2.009