Nolan Ryan has the most career starts in losses, with 455 starts.

Interpreted as:

most MLB regular-season games started without a win by a player

	NAME	GS	W	L	W%	G	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	455	0	292	.000	483	4.81	2,912	59	0	3	2801.2	2,510	1,496	1,699	247	1,662	96	9	66	12,456	190	9.35	5.34	1.75	0.79	23.4	13.3	1.49	.300	5.46	8.06
2	Don Sutton D. Sutton	435	0	256	.000	450	4.78	1,823	27	0	5	2709.2	2,855	1,440	1,575	324	830	61	10	87	11,709	66	6.05	2.76	2.20	1.08	15.6	7.1	1.36	.292	5.23	9.48
3	Tommy John T. John	416	0	231	.000	472	5.01	1,194	33	0	3	2427.1	2,943	1,350	1,542	217	817	56	19	76	10,808	137	4.43	3.03	1.46	0.80	11.0	7.6	1.55	.320	5.72	10.91
4	Phil Niekro P. Niekro	414	0	274	.000	546	4.75	1,776	65	0	29	2872.2	3,168	1,515	1,764	335	1,100	67	69	75	12,688	150	5.56	3.45	1.61	1.05	14.0	8.7	1.49	.301	5.53	9.93
5	Bert Blyleven B. Blyleven	399	0	250	.000	405	4.83	1,898	75	0	0	2633.1	2,941	1,414	1,558	325	799	97	3	54	11,459	77	6.49	2.73	2.38	1.11	16.6	7.0	1.42	.314	5.32	10.05
6	Greg Maddux G. Maddux	385	0	227	.000	389	4.59	1,604	17	0	0	2406.0	2,706	1,227	1,388	228	583	80	3	134	10,383	41	6.00	2.18	2.75	0.85	15.4	5.6	1.37	.314	5.19	10.12
7	Gaylord Perry G. Perry	385	0	265	.000	463	4.64	1,772	77	0	10	2702.0	3,033	1,393	1,596	292	828	68	28	135	11,741	108	5.90	2.76	2.14	0.97	15.1	7.1	1.43	.312	5.32	10.10
8	Steve Carlton S. Carlton	382	0	244	.000	412	4.91	1,875	38	0	2	2434.1	2,675	1,328	1,528	291	1,044	28	12	120	10,823	91	6.93	3.86	1.80	1.08	17.3	9.6	1.53	.314	5.65	9.89
9	Frank Tanana F. Tanana	380	0	236	.000	398	5.07	1,485	44	0	1	2318.0	2,623	1,305	1,469	317	807	86	8	96	10,266	74	5.77	3.13	1.84	1.23	14.5	7.9	1.48	.305	5.70	10.18
10	Tom Glavine T. Glavine	377	0	203	.000	377	5.12	1,289	6	0	0	2206.1	2,567	1,255	1,361	239	937	39	0	113	9,907	36	5.26	3.82	1.38	0.97	13.0	9.5	1.59	.314	5.55	10.47
11	Jamie Moyer J. Moyer	376	0	209	.000	427	5.80	1,331	9	0	0	2240.1	2,727	1,445	1,557	360	760	87	12	58	10,050	44	5.35	3.05	1.75	1.45	13.2	7.6	1.56	.315	6.25	10.96
12	Jim Kaat J. Kaat	365	0	237	.000	615	4.95	1,189	34	0	17	2332.0	2,816	1,282	1,502	262	700	75	87	93	10,389	76	4.59	2.70	1.70	1.01	11.4	6.7	1.51	.313	5.80	10.87
13	Roger Clemens R. Clemens	353	0	184	.000	355	4.80	2,073	26	0	0	2234.2	2,294	1,192	1,332	238	900	89	0	51	9,788	79	8.35	3.62	2.30	0.96	21.2	9.2	1.43	.317	5.36	9.24
14	Tom Seaver T. Seaver	337	0	205	.000	345	4.32	1,626	45	0	1	2208.0	2,231	1,061	1,180	249	762	49	5	92	9,469	80	6.63	3.11	2.13	1.01	17.2	8.0	1.36	.292	4.81	9.09
15	Jerry Reuss J. Reuss	335	0	191	.000	408	5.47	1,022	10	0	11	1938.1	2,420	1,179	1,356	193	709	46	34	96	8,820	71	4.75	3.29	1.44	0.90	11.6	8.0	1.61	.325	6.30	11.24
16	Robin Roberts R. Roberts	334	0	245	.000	390	4.91	1,077	67	0	25	2222.1	2,629	1,213	1,354	322	512	28	40	63	9,647	19	4.36	2.07	2.10	1.30	11.2	5.3	1.41	.299	5.48	10.65
17	Dennis Martinez D. Martinez	332	0	193	.000	447	5.07	1,178	28	0	8	2173.0	2,453	1,225	1,365	257	748	84	40	59	9,562	60	4.88	3.10	1.57	1.06	12.3	7.8	1.47	.301	5.65	10.16
18	Early Wynn E. Wynn	324	0	244	.000	391	5.86	978	65	0	15	2023.2	2,455	1,318	1,501	227	941	37	54	32	9,325	29	4.35	4.18	1.04	1.01	10.5	10.1	1.68	.312	6.68	10.92
19	Zack Greinke Z. Greinke	321	0	156	.000	361	4.84	1,567	7	0	1	1883.0	2,076	1,013	1,091	274	498	57	8	17	8,107	57	7.49	2.38	3.15	1.31	19.3	6.1	1.37	.316	5.21	9.92
20	Rick Reuschel R. Reuschel	321	0	191	.000	343	4.77	1,110	23	0	5	1938.2	2,280	1,028	1,147	166	579	65	11	93	8,552	60	5.15	2.69	1.92	0.77	13.0	6.8	1.47	.319	5.32	10.58
21	Fergie Jenkins F. Jenkins	316	0	226	.000	380	5.02	1,437	59	0	7	2106.2	2,360	1,176	1,296	307	588	46	33	88	9,163	32	6.14	2.51	2.44	1.31	15.7	6.4	1.40	.303	5.54	10.08
22	Jerry Koosman J. Koosman	311	0	209	.000	390	4.79	1,315	19	0	17	2043.0	2,262	1,087	1,221	199	728	46	39	100	8,937	55	5.79	3.21	1.81	0.88	14.7	8.1	1.46	.310	5.38	9.96
23	Bob Friend B. Friend	311	0	230	.000	405	5.11	896	30	0	10	1984.1	2,442	1,126	1,304	203	566	30	47	90	8,806	38	4.06	2.57	1.58	0.92	10.2	6.4	1.52	.315	5.91	11.08
24	CC Sabathia	309	0	161	.000	310	5.37	1,524	10	0	0	1803.1	2,054	1,075	1,172	269	645	75	0	30	8,014	44	7.61	3.22	2.36	1.34	19.0	8.0	1.50	.324	5.85	10.25
25	Warren Spahn W. Spahn	307	0	245	.000	387	5.19	1,004	60	0	28	2057.0	2,401	1,187	1,330	261	676	24	63	38	9,091	41	4.39	2.96	1.49	1.14	11.0	7.4	1.50	.300	5.82	10.51