Between the 1904 and 1913 seasons, Ed Walsh fanned the most hitters, with 1,702 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Ed Walsh E. Walsh	1,702	413	190	121	.611	303	1.79	243	55	35	2871.1	2,268	572	838	23	578	50	102	11,036	74	5.33	1.81	2.94	0.07	15.4	5.2	0.99	.259	2.63	68	1.99	78	7.11	166.7
2	Christy Mathewson C. Mathewson	1,684	429	273	107	.718	372	1.87	286	56	24	3195.1	2,740	664	938	49	503	19	51	12,433	47	4.74	1.42	3.35	0.14	13.5	4.0	1.01	.264	2.64	66	2.06	70	7.72	303.9
3	Eddie Plank E. Plank	1,502	378	209	111	.653	332	2.17	258	50	13	2778.2	2,370	671	905	22	677	125	39	10,930	52	4.86	2.19	2.22	0.07	13.7	6.2	1.10	.273	2.93	81	2.31	87	7.68	102.3
4	Walter Johnson W. Johnson	1,461	273	151	97	.609	230	1.60	198	44	8	2070.1	1,586	368	578	22	417	74	40	7,993	80	6.35	1.81	3.50	0.10	18.3	5.2	0.97	.260	2.51	59	1.91	70	6.89	187.9
5	Rube Waddell R. Waddell	1,453	263	119	88	.575	213	1.94	149	40	4	1808.0	1,451	389	589	15	504	65	38	7,072	42	7.23	2.51	2.88	0.07	20.5	7.1	1.08	.285	2.93	76	1.76	71	7.22	147.6
6	Chief Bender C. Bender	1,302	321	159	85	.652	232	2.23	185	27	26	2153.0	1,827	533	744	20	494	52	81	8,390	59	5.44	2.07	2.64	0.08	15.5	5.9	1.08	.277	3.11	82	2.10	78	7.64	132.5
7	Red Ames R. Ames	1,235	311	117	90	.565	234	2.50	138	15	14	1976.0	1,722	548	806	24	682	44	53	8,013	116	5.63	3.11	1.81	0.11	15.4	8.5	1.22	.282	3.67	87	2.45	83	7.84	109.9
8	George Mullin G. Mullin	1,146	370	180	153	.541	338	2.78	283	28	4	2870.2	2,709	888	1,231	30	930	105	29	11,726	61	3.59	2.92	1.23	0.09	9.8	7.9	1.27	.282	3.86	101	2.82	105	8.49	-35
9	Nap Rucker N. Rucker	1,130	292	116	123	.485	239	2.39	173	37	13	2111.2	1,808	560	710	36	639	68	50	8,322	39	4.82	2.72	1.77	0.15	13.6	7.7	1.16	.275	3.03	85	2.58	89	7.71	69.2
10	Cy Young C. Young	1,069	273	132	116	.532	250	2.20	218	29	7	2214.2	1,932	541	756	26	286	44	20	8,457	44	4.34	1.16	3.74	0.11	12.6	3.4	1.00	.271	3.07	83	1.97	76	7.85	150.5
11	Mordecai Brown M. Brown	1,063	373	197	95	.675	253	1.83	215	49	45	2454.0	2,001	500	731	26	480	41	112	9,466	40	3.90	1.76	2.21	0.10	11.2	5.1	1.01	.251	2.68	64	2.29	80	7.34	153.1
12	Earl Moore E. Moore	976	256	99	99	.500	208	2.71	132	21	3	1789.1	1,556	538	747	42	739	76	34	7,412	41	4.91	3.72	1.32	0.21	13.2	10.0	1.28	.271	3.76	92	3.06	103	7.83	-15.6
13	Tom Hughes T. Hughes	959	304	91	135	.403	223	3.06	151	18	15	1912.1	1,867	651	929	41	615	72	68	7,909	57	4.51	2.89	1.56	0.19	12.1	7.8	1.30	.293	4.37	113	2.79	105	8.79	-33.8
14	Doc White D. White	953	323	142	107	.570	265	2.32	177	39	4	2198.1	1,962	567	751	24	473	79	47	8,675	42	3.90	1.94	2.01	0.10	11.0	5.5	1.11	.271	3.07	90	2.43	97	8.03	4.9
15	Orval Overall O. Overall	935	218	108	71	.603	182	2.26	133	30	12	1535.1	1,232	385	520	16	551	45	30	6,145	57	5.48	3.23	1.70	0.09	15.2	9.0	1.16	.264	3.05	81	2.39	85	7.22	72.4
16	Hooks Wiltse H. Wiltse	929	319	135	84	.616	222	2.47	151	27	27	2015.0	1,802	553	744	51	479	38	83	8,026	39	4.15	2.14	1.94	0.23	11.6	6.0	1.13	.268	3.32	89	2.55	89	8.05	68.4
17	Frank Smith F. Smith	907	283	120	97	.553	219	2.44	169	25	4	1947.2	1,618	529	721	12	580	41	56	7,689	61	4.19	2.68	1.56	0.06	11.8	7.5	1.13	.261	3.33	96	2.44	100	7.48	-11.2
18	Bill Donovan B. Donovan	891	224	122	80	.604	207	2.53	179	25	3	1824.1	1,610	512	697	24	589	59	17	7,403	31	4.40	2.91	1.51	0.12	12.0	8.0	1.21	.272	3.44	94	2.62	100	7.94	3.9
19	Jack Coombs J. Coombs	869	236	115	66	.635	189	2.59	135	28	8	1621.2	1,379	466	618	17	603	59	38	6,537	45	4.82	3.35	1.44	0.09	13.3	9.2	1.22	.273	3.43	92	2.75	102	7.65	-14.1
20	Jack Powell J. Powell	864	298	111	139	.444	259	2.55	192	24	8	2188.1	2,023	620	886	39	484	51	34	8,712	33	3.55	1.99	1.79	0.16	9.9	5.6	1.15	.273	3.64	93	2.59	98	8.32	14
21	Joe Wood J. Wood	856	175	92	48	.657	127	2.00	100	24	6	1145.1	903	254	415	8	334	48	39	4,520	35	6.73	2.62	2.56	0.06	18.9	7.4	1.08	.273	3.26	68	2.20	76	7.10	94.4
22	Bob Ewing B. Ewing	850	247	105	99	.515	224	2.43	168	18	3	1936.2	1,717	522	746	27	503	42	23	7,613	38	3.95	2.34	1.69	0.13	11.2	6.6	1.15	.273	3.47	87	2.46	86	7.98	89
23	Ed Reulbach E. Reulbach	845	296	143	71	.668	228	2.23	157	33	9	1974.2	1,536	489	640	24	684	89	56	7,841	31	3.85	3.12	1.24	0.11	10.8	8.7	1.12	.244	2.92	78	2.88	99	7.00	1.2
24	Vic Willis V. Willis	835	277	128	112	.533	253	2.52	195	30	6	2113.0	1,932	592	820	29	574	50	24	8,488	44	3.56	2.44	1.45	0.12	9.8	6.8	1.19	.272	3.49	94	2.59	94	8.23	33.8
25	Howie Camnitz H. Camnitz	827	286	119	87	.578	201	2.66	117	19	14	1803.1	1,577	533	714	32	555	57	71	7,249	33	4.13	2.77	1.49	0.16	11.4	7.7	1.18	.267	3.56	90	2.78	93	7.87	36.3