Mariano Rivera has the most career saves by a pitcher against a team, with 79 saves versus the Orioles.

Interpreted as:

most regular-season pitching saves by a player against one team

	NAME	SV	OPP	G	W	L	W%	GS	ERA	SO	CG	SHO	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Mariano Rivera M. Rivera	79	Orioles	136	9	9	.500	0	3.04	105	0	0	142.0	119	48	50	12	27	4	115	3	566	1	6.65	1.71	3.89	0.76	18.6	4.8	1.03	.256	3.17	7.54
2	Trevor Hoffman T. Hoffman	68	Dodgers	100	4	8	.333	0	2.92	105	0	0	101.2	87	33	36	9	30	3	85	3	420	5	9.30	2.66	3.50	0.80	25.0	7.1	1.15	.286	3.19	7.70
3	Mariano Rivera M. Rivera	64	Rays	103	4	6	.400	0	1.69	113	0	0	106.1	73	20	21	4	25	5	96	5	411	0	9.56	2.12	4.52	0.34	27.5	6.1	0.92	.261	1.78	6.18
4	Kenley Jansen K. Jansen	58	Diamondbacks	101	8	1	.889	0	2.47	141	0	0	102.0	61	28	30	14	28	3	82	3	393	1	12.44	2.47	5.04	1.24	35.9	7.1	0.87	.227	2.65	5.38
5	Mariano Rivera M. Rivera	58	Red Sox	115	13	7	.650	0	2.86	120	0	0	126.0	120	40	47	8	37	9	97	6	546	1	8.57	2.64	3.24	0.57	22.0	6.8	1.25	.301	3.36	8.57
6	Mariano Rivera M. Rivera	54	Blue Jays	94	8	2	.800	0	1.81	107	0	0	104.1	83	21	21	4	17	1	78	2	407	2	9.23	1.47	6.29	0.35	26.3	4.2	0.96	.284	1.81	7.16
7	Trevor Hoffman T. Hoffman	54	Rockies	87	7	8	.467	0	3.57	95	0	0	90.2	75	36	40	13	22	2	75	3	369	5	9.43	2.18	4.32	1.29	25.7	6.0	1.07	.262	3.97	7.44
8	Trevor Hoffman T. Hoffman	51	Giants	98	6	6	.500	0	2.78	97	0	0	103.2	90	32	33	6	30	2	78	9	424	4	8.42	2.60	3.23	0.52	22.9	7.1	1.16	.291	2.86	7.81
9	Lee Smith L. Smith	49	Phillies	96	9	14	.391	2	2.85	128	0	0	129.2	118	41	46	12	44	1	77	10	540	4	8.88	3.05	2.91	0.83	23.7	8.1	1.25	.299	3.19	8.19
10	Kenley Jansen K. Jansen	48	Padres	97	4	5	.444	0	2.31	146	0	0	97.1	63	25	27	8	29	3	72	1	384	3	13.50	2.68	5.03	0.74	38.0	7.6	0.95	.278	2.50	5.83
11	Trevor Hoffman T. Hoffman	46	Diamondbacks	68	2	4	.333	0	2.51	72	0	0	68.0	45	19	19	8	20	0	56	3	264	2	9.53	2.65	3.60	1.06	27.3	7.6	0.96	.226	2.51	5.96
12	Joe Nathan J. Nathan	45	Royals	73	4	0	1.000	0	1.34	88	0	0	73.2	45	11	13	4	15	4	60	3	283	1	10.75	1.83	5.87	0.49	31.1	5.3	0.81	.238	1.59	5.50
13	Mariano Rivera M. Rivera	43	White Sox	63	4	2	.667	1	1.26	74	0	0	86.0	51	12	12	2	16	3	53	0	317	2	7.74	1.67	4.63	0.21	23.3	5.0	0.78	.221	1.26	5.34
14	Billy Wagner B. Wagner	42	Reds	68	3	3	.500	0	2.18	95	0	0	70.1	40	17	20	4	23	3	58	0	275	4	12.16	2.94	4.13	0.51	34.5	8.4	0.90	.240	2.56	5.12
15	Trevor Hoffman T. Hoffman	41	Pirates	69	3	3	.500	0	2.21	64	0	0	73.1	53	18	23	4	17	0	58	6	294	3	7.85	2.09	3.76	0.49	21.8	5.8	0.95	.234	2.82	6.50
16	Mariano Rivera M. Rivera	40	Rangers	72	6	4	.600	1	2.23	62	0	0	88.2	86	22	24	3	22	3	59	6	374	1	6.29	2.23	2.82	0.30	16.6	5.9	1.22	.292	2.44	8.73
17	John Franco J. Franco	40	Phillies	102	8	11	.421	0	2.89	98	0	0	109.0	99	35	43	8	51	1	65	7	469	4	8.09	4.21	1.92	0.66	20.9	10.9	1.38	.293	3.55	8.17
18	John Franco J. Franco	40	Braves	106	5	7	.417	0	3.48	74	0	0	106.0	102	41	45	9	52	4	74	7	464	4	6.28	4.42	1.42	0.76	15.9	11.2	1.45	.286	3.82	8.66
19	John Franco J. Franco	39	Expos	94	6	6	.500	0	2.61	77	0	0	103.1	92	30	33	7	36	1	67	7	428	5	6.71	3.14	2.14	0.61	18.0	8.4	1.24	.277	2.87	8.01
20	Kenley Jansen K. Jansen	38	Rockies	78	5	0	1.000	0	2.40	105	0	0	82.1	54	22	23	6	22	2	58	0	322	3	11.48	2.40	4.77	0.66	32.6	6.8	0.92	.257	2.51	5.90
21	Joe Nathan J. Nathan	38	Indians	64	4	3	.571	0	3.80	73	0	0	64.0	51	27	27	11	18	0	54	1	258	3	10.27	2.53	4.06	1.55	28.3	7.0	1.08	.256	3.80	7.17
22	Trevor Hoffman T. Hoffman	38	Cubs	64	3	6	.333	0	2.51	65	0	0	68.0	50	19	20	5	12	0	54	3	266	0	8.60	1.59	5.42	0.66	24.4	4.5	0.91	.245	2.65	6.62
23	Lee Smith L. Smith	38	Mets	85	9	13	.409	0	3.24	95	0	0	105.2	104	38	44	5	40	1	69	14	462	7	8.09	3.41	2.38	0.43	20.6	8.7	1.36	.308	3.75	8.86
24	Bruce Sutter B. Sutter	38	Mets	70	3	5	.375	0	2.88	90	0	0	112.2	97	36	40	8	24	1	54	5	453	4	7.19	1.92	3.75	0.64	19.9	5.3	1.07	.270	3.20	7.75
25	Kenley Jansen K. Jansen	37	Giants	80	2	7	.222	0	3.55	119	0	0	76.0	72	30	32	7	31	3	54	2	334	6	14.09	3.67	3.84	0.83	35.6	9.3	1.36	.374	3.79	8.53