Between the 2000 and 2021 seasons, CC Sabathia won the most games, with 251 wins.

Interpreted as:

most pitching regular-season wins by a player from 2000 to 2021

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	CC Sabathia	251	161	.609	561	560	3.74	3,093	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
2	Justin Verlander J. Verlander	226	129	.637	454	454	3.33	3,013	26	9	0	2988.0	2,538	1,105	1,192	310	851	98	0	27	12,214	87	9.08	2.56	3.54	0.93	24.7	7.0	1.13	.281	3.59	78	3.40	80	7.64	280.4
3	Zack Greinke Z. Greinke	219	132	.624	530	488	3.41	2,809	17	5	1	3110.0	2,892	1,179	1,263	328	712	72	8	25	12,699	92	8.13	2.06	3.95	0.95	22.1	5.6	1.16	.292	3.65	81	3.43	83	8.37	244.3
4	Mark Buehrle M. Buehrle	214	160	.572	518	493	3.81	1,870	33	10	0	3283.1	3,472	1,391	1,542	361	734	79	6	49	13,705	27	5.13	2.01	2.55	0.99	13.6	5.4	1.28	.292	4.23	87	4.11	93	9.52	111.9
5	Bartolo Colon B. Colon	211	167	.558	483	472	4.11	2,150	30	10	0	2958.2	3,096	1,351	1,465	388	748	51	2	36	12,487	32	6.54	2.28	2.87	1.18	17.2	6.0	1.30	.296	4.46	96	4.14	97	9.42	44.8
6	Tim Hudson T. Hudson	211	131	.617	461	458	3.50	1,948	25	13	0	2990.1	2,836	1,164	1,263	240	855	120	0	82	12,425	78	5.86	2.57	2.28	0.72	15.7	6.9	1.23	.280	3.80	84	3.79	91	8.54	131.3
7	Jon Lester J. Lester	200	117	.631	452	451	3.66	2,488	15	4	0	2740.0	2,610	1,114	1,215	294	892	90	0	13	11,487	63	8.17	2.93	2.79	0.97	21.7	7.8	1.28	.300	3.99	86	3.77	92	8.57	101.7
8	Roy Halladay R. Halladay	194	98	.664	378	370	3.36	2,022	65	19	0	2586.0	2,481	966	1,055	215	511	77	4	27	10,566	50	7.04	1.78	3.96	0.75	19.1	4.8	1.16	.293	3.67	77	3.27	75	8.63	304.7
9	Max Scherzer M. Scherzer	190	97	.662	407	398	3.16	3,020	12	5	0	2536.2	2,072	890	959	287	677	96	2	20	10,266	73	10.71	2.40	4.46	1.02	29.4	6.6	1.08	.289	3.40	76	3.12	75	7.35	288.2
10	John Lackey J. Lackey	188	147	.561	448	446	3.92	2,294	18	8	0	2840.1	2,862	1,237	1,347	319	815	133	0	32	12,030	125	7.27	2.58	2.81	1.01	19.1	6.8	1.29	.300	4.27	92	3.94	94	9.07	79.6
11	Clayton Kershaw C. Kershaw	185	84	.688	379	376	2.49	2,670	25	15	0	2454.2	1,859	679	741	196	606	37	1	27	9,667	95	9.79	2.22	4.41	0.72	27.6	6.3	1.00	.270	2.72	64	2.76	69	6.82	338
12	Adam Wainwright A. Wainwright	184	105	.637	425	358	3.35	2,004	27	11	3	2375.2	2,234	885	948	197	641	73	13	39	9,829	45	7.59	2.43	3.13	0.75	20.4	6.5	1.21	.295	3.59	84	3.42	84	8.46	167
13	Andy Pettitte A. Pettitte	175	107	.621	366	363	3.82	1,739	12	3	0	2271.2	2,361	963	1,080	203	655	39	1	33	9,631	40	6.89	2.60	2.65	0.80	18.1	6.8	1.33	.309	4.28	86	3.63	82	9.35	201.4
14	Felix Hernandez F. Hernandez	169	136	.554	419	418	3.42	2,524	25	11	0	2729.2	2,487	1,037	1,157	264	805	105	0	16	11,284	156	8.32	2.65	3.14	0.87	22.4	7.1	1.21	.293	3.81	84	3.52	85	8.20	181.5
15	Derek Lowe D. Lowe	165	139	.543	524	358	4.03	1,513	10	4	67	2370.0	2,475	1,061	1,184	194	704	66	127	58	10,097	44	5.75	2.67	2.15	0.74	15.0	7.0	1.34	.299	4.50	94	3.83	90	9.40	111.4
16	Barry Zito B. Zito	165	143	.536	433	421	4.04	1,885	12	5	0	2576.2	2,381	1,157	1,254	282	1,064	97	9	52	11,001	50	6.58	3.72	1.77	0.98	17.1	9.7	1.34	.274	4.38	97	4.38	104	8.32	-43.1
17	Cole Hamels C. Hamels	163	122	.572	423	422	3.43	2,560	17	7	0	2698.0	2,424	1,027	1,103	310	767	100	0	43	11,115	57	8.54	2.56	3.34	1.03	23.0	6.9	1.18	.287	3.68	82	3.68	88	8.09	151.3
18	Roy Oswalt R. Oswalt	163	102	.615	365	341	3.36	1,852	20	8	0	2245.1	2,199	838	897	197	520	80	7	34	9,301	30	7.42	2.08	3.56	0.79	19.9	5.6	1.21	.301	3.60	79	3.36	78	8.81	236.2
19	A.J. Burnett	160	155	.508	428	423	3.99	2,480	24	10	0	2690.0	2,482	1,194	1,305	260	1,075	143	1	33	11,483	161	8.30	3.60	2.31	0.87	21.6	9.4	1.32	.295	4.37	97	3.85	92	8.30	96.2
20	David Price D. Price	155	82	.654	360	322	3.33	2,039	17	3	1	2103.1	1,892	779	854	215	553	63	6	14	8,640	40	8.72	2.37	3.69	0.92	23.6	6.4	1.16	.291	3.65	81	3.37	83	8.10	165.2
21	Dan Haren D. Haren	153	131	.539	391	380	3.75	2,013	16	6	1	2419.2	2,357	1,009	1,105	305	500	67	4	39	10,022	98	7.49	1.86	4.03	1.13	20.1	5.0	1.18	.288	4.11	92	3.77	92	8.77	92.8
22	Jake Peavy J. Peavy	152	126	.547	388	377	3.63	2,207	15	6	0	2377.0	2,134	960	1,011	259	708	78	3	42	9,838	46	8.36	2.68	3.12	0.98	22.4	7.2	1.20	.285	3.83	90	3.64	89	8.08	127.6
23	Ervin Santana E. Santana	151	129	.539	425	386	4.11	1,978	21	11	0	2486.2	2,391	1,135	1,221	331	776	104	20	35	10,482	104	7.16	2.81	2.55	1.20	18.9	7.4	1.27	.282	4.42	99	4.31	104	8.65	-44.1
24	Livan Hernandez L. Hernandez	151	150	.502	438	394	4.45	1,596	39	9	1	2655.2	2,949	1,312	1,404	297	846	67	17	72	11,472	35	5.41	2.87	1.89	1.01	13.9	7.4	1.43	.306	4.76	105	4.35	102	9.99	-29.4
25	Jamie Moyer J. Moyer	151	108	.583	350	344	4.30	1,277	13	4	0	2145.2	2,203	1,025	1,093	301	588	88	2	33	9,128	21	5.36	2.47	2.17	1.26	14.0	6.4	1.30	.277	4.58	99	4.65	106	9.24	-66