Between the 2000 and 2009 seasons, the Texas Rangers had the most runs by a team in a game, with 30 runs against the Orioles on August 22, 2007.

Interpreted as:

most run in a regular-season game by team in 2000s

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rangers	30	8/22/2007	TEX	@	BAL	W 30-3	57	29	2	0	6	30	8	0	11	0	0	65	49	8	0	0	0	0	.509	.569	.860	1.429
2	Royals	26	9/9/2004	KCR	@	DET	W 26-5	52	26	5	1	1	25	8	0	6	0	0	62	36	7	0	2	0	0	.500	.548	.692	1.241
3	Red Sox	25	6/27/2003	BOS	vs	FLA	W 25-8	46	28	8	1	3	25	7	1	7	0	0	57	47	12	0	3	0	1	.609	.632	1.022	1.653
4	Twins	23	6/4/2002	MIN	vs	CLE	W 23-2	50	25	6	1	3	22	7	0	4	0	0	57	42	10	0	0	1	0	.500	.561	.840	1.401
5	Athletics	23	9/30/2000	OAK	vs	TEX	W 23-2	48	24	5	0	4	23	10	0	10	0	0	58	41	9	0	0	0	0	.500	.586	.854	1.440
6	Orioles	23	9/28/2000	BAL	vs	TOR	W 23-1	47	23	2	0	3	20	5	1	5	0	0	54	34	5	0	1	0	1	.489	.537	.723	1.260
7	Phillies	22	7/6/2009	PHI	vs	CIN	W 22-1	43	21	6	0	4	21	7	1	9	0	0	52	39	10	0	1	0	1	.488	.558	.907	1.465
8	Indians	22	4/18/2009	CLE	@	NYY	W 22-4	52	25	7	0	6	22	6	0	10	0	0	58	50	13	0	0	0	0	.481	.534	.962	1.496
9	Indians	22	8/31/2004	CLE	@	NYY	W 22-0	49	22	5	1	3	22	9	0	6	1	0	59	38	9	0	1	0	0	.449	.525	.776	1.301
10	Red Sox	22	7/23/2002	BOS	vs	TBD	W 22-4	44	19	5	0	7	21	7	0	4	1	0	51	45	12	0	0	0	0	.432	.510	1.023	1.533
11	Dodgers	22	7/21/2001	LAD	@	COL	W 22-7	48	23	3	1	4	20	2	3	4	0	0	54	40	8	1	0	1	1	.479	.528	.833	1.362
12	Yankees	22	6/19/2000	NYY	@	BOS	W 22-1	47	19	4	1	5	21	7	0	4	1	0	55	40	10	0	1	1	0	.404	.473	.851	1.324
13	Yankees	21	7/22/2007	NYY	vs	TBD	W 21-4	48	25	4	1	6	20	7	1	8	3	0	56	49	11	0	0	0	1	.521	.589	1.021	1.610
14	Angels	21	8/25/2004	ANA	vs	KCR	W 21-6	46	22	3	1	3	20	4	2	6	0	0	52	36	7	0	0	0	2	.478	.538	.783	1.321
15	Angels	21	4/30/2002	ANA	@	CLE	W 21-2	49	22	2	0	3	18	7	2	4	3	0	59	33	5	0	1	1	0	.449	.525	.673	1.199
16	Mariners	21	9/30/2000	SEA	@	ANA	W 21-9	46	22	4	1	5	20	11	0	9	2	1	59	43	10	1	1	0	0	.478	.569	.935	1.504
17	Athletics	21	6/18/2000	OAK	@	KCR	W 21-3	46	21	5	0	4	21	10	0	8	0	0	57	38	9	0	1	0	0	.457	.544	.826	1.370
18	Yankees	20	8/21/2009	NYY	@	BOS	W 20-11	49	23	8	1	2	20	5	0	5	0	0	54	39	11	0	0	0	1	.469	.519	.796	1.314
19	Twins	20	5/21/2009	MIN	@	CWS	W 20-1	46	20	4	0	4	18	5	1	5	0	0	54	36	8	1	1	1	0	.435	.491	.783	1.273
20	Phillies	20	6/13/2008	PHI	@	STL	W 20-2	47	21	6	0	4	19	8	1	9	0	0	57	39	10	0	1	0	0	.447	.526	.830	1.356
21	Phillies	20	5/26/2008	PHI	vs	COL	W 20-5	41	19	5	0	2	20	8	2	8	2	0	54	30	7	2	1	0	0	.463	.558	.732	1.289
22	Twins	20	7/6/2007	MIN	@	CWS	W 20-14	47	21	4	0	2	20	8	0	1	0	0	57	31	6	0	2	1	1	.447	.509	.660	1.168
23	Rockies	20	9/18/2006	COL	vs	SFG	W 20-8	41	19	5	0	4	20	7	1	7	0	0	51	36	9	2	0	0	0	.463	.551	.878	1.429
24	White Sox	20	6/20/2006	CWS	vs	STL	W 20-6	49	24	3	0	4	19	1	2	5	0	0	52	39	7	0	0	0	0	.490	.519	.796	1.315
25	Rockies	20	9/20/2005	COL	vs	SDP	W 20-1	48	23	5	1	4	20	3	1	6	0	0	53	42	10	0	1	0	0	.479	.509	.875	1.384